A5086990128- Microtubule and mitosis dynamics
- Biotechnology and Related Fields
- Genetics, Bioinformatics, and Biomedical Research
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Digestive system and related health
- Cancer Research and Treatments
- Biomedical Research and Pathophysiology
- Liver physiology and pathology
- Nutrition and Health in Aging
- Extracellular vesicles in disease
- Child Nutrition and Feeding Issues
- Milk Quality and Mastitis in Dairy Cows
- Signaling Pathways in Disease
- Pancreatic function and diabetes
- Probiotics and Fermented Foods
- Liver Disease Diagnosis and Treatment
- DNA Repair Mechanisms
- Diet, Metabolism, and Disease
- CRISPR and Genetic Engineering
Consejo Nacional de Investigaciones Científicas y Técnicas
2019-2024
Instituto Multidisciplinario de Biología Vegetal
2024
Research Centre in Biological Chemistry of Córdoba
2019
Universidad Nacional de Córdoba
2019
Hospital de Clínicas de Porto Alegre
2017-2018
Universidade Federal do Rio Grande do Sul
2018
BRCA1 and BRCA2 deficiencies are widespread drivers of human cancers that await the development targeted therapies. We aimed to identify novel synthetic lethal relationships with therapeutic potential using BRCA-deficient isogenic backgrounds.We developed a phenotypic screening technology simultaneously search for (SL) interactions in BRCA1- BRCA2-deficient contexts. For validation, we chimeric spheroids dual-tumor xenograft model allowed confirmation SL induction concomitant evaluation...
Translesion DNA synthesis (TLS) and homologous recombination (HR) cooperate during S-phase to safeguard replication forks integrity. Thus, the inhibition of TLS becomes a promising point therapeutic intervention in HR-deficient cancers, where impairment might trigger synthetic lethality (SL). The main limitation test this hypothesis is current lack selective pharmacological inhibitors TLS. Herein, we developed miniaturized screening assay identify PCNA ubiquitylation, key post-translational...
Hepatocellular carcinoma is a common cancer, ranking third in cancer-associated deaths. An important cause of cancer patients’ mortality metastasis. At the start metastasis progression, there an epithelial-mesenchymal transition, characterized by matrix degradation, junction reductions and vessels formation. HuH-7 cell line used research as vitro model for hepatocellular carcinoma. It known that two-dimensional growth reflects tumor characteristics poorly. In contrast, three-dimensional...
<p>Extended methods including bionformatic analysis details and scripts used</p>
<p>Legends included in the figure file</p>
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<p>Full list of hits the BRCA1-deficient population in screening performed with PKIS2 library</p>
<p>Legends included in the figure file</p>
<p>Legends included in the figure file</p>
<p>Extended methods including bionformatic analysis details and scripts used</p>
<p>Full list of hits the BRCA1-deficient population in screening performed with PKIS2 library</p>
<p>Legends included in the figure file</p>
<p>Legends included in the figure file</p>
<p>Legends included in the figure file</p>
<p>Legends included in the figure file</p>
<p>Legends included in the figure file</p>
<p>Legends included in the figure file</p>
<div>AbstractPurpose:<p>BRCA1 and BRCA2 deficiencies are widespread drivers of human cancers that await the development targeted therapies. We aimed to identify novel synthetic lethal relationships with therapeutic potential using BRCA-deficient isogenic backgrounds.</p>Experimental Design:<p>We developed a phenotypic screening technology simultaneously search for (SL) interactions in BRCA1- BRCA2-deficient contexts. For validation, we chimeric spheroids dual-tumor...
<div>AbstractPurpose:<p>BRCA1 and BRCA2 deficiencies are widespread drivers of human cancers that await the development targeted therapies. We aimed to identify novel synthetic lethal relationships with therapeutic potential using BRCA-deficient isogenic backgrounds.</p>Experimental Design:<p>We developed a phenotypic screening technology simultaneously search for (SL) interactions in BRCA1- BRCA2-deficient contexts. For validation, we chimeric spheroids dual-tumor...