A5028955183- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Photodynamic Therapy Research Studies
- Cancer-related gene regulation
- 3D Printing in Biomedical Research
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Fatty Acid Research and Health
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Macrophage Migration Inhibitory Factor
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Photochromic and Fluorescence Chemistry
- Multiple and Secondary Primary Cancers
- Galectins and Cancer Biology
- Nuclear Receptors and Signaling
- Tannin, Tannase and Anticancer Activities
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Hepatitis B Virus Studies
- Bone Tissue Engineering Materials
- Additive Manufacturing and 3D Printing Technologies
- Tissue Engineering and Regenerative Medicine
Southern Medical University
2013-2022
Nanfang Hospital
2013-2022
Xinqiao Hospital
2020-2021
Central South University
2019
Macrophage migration inhibitory factor (MIF) is upregulated in various solid tumors, a process that associated with tumor progression and metastasis. The present study aimed to investigate the role underlying mechanism of MIF human lung cancer. Human cancer H358, H460, H524, H1650, H838, H1975 A549 cell lines were used examine expression by real time‑quantitative polymerase chain reaction western blotting. lentivirus was overexpress hypoxia‑inducible 1‑α (HIF‑1α) knocked down shRNA or siRNA....
The design and synthesis of near-infrared (NIR) emissive fluorophores for the imaging organelles photodynamic therapy have received enormous attention. Hence, development NIR high-fidelity lysosome targeting, two-photon fluorescence imaging, inducing photo-triggered cancer-cell apoptosis is highly desirable. In this study, a novel lysosome-targeting fluorescent photosensitizer (TTRh-CN) prepared comprehensively investigated. TTRh-CN demonstrates emission, good biocompatibility, superior...
A thermosensitive nanoplatform CDTSL achieves NIR light controlled drug release and can be applied for photoacoustic imaging chemo-photothermal therapy.
Background: Pleural effusion is one of the complications human non-small cell lung cancer (NSCLC). High mobility group box-1 protein (HMGB1) correlates highly with invasion and metastasis in multiple tumors. The aim this study was to explore clinical value HMGB1 NSCLC patients, investigate role development pleural effusion. In addition, we also investigated regulatory sensitivity cells cisplatin. Methods: 46 malignant (MPE) 31 benign samples were quantitatively analyzed Enzyme-Linked...
Two-photon fluorescence imaging and efficient photodynamic therapy of tumors by a lysosome-targeted near-infrared photosensitizer (<bold>TTR</bold>) are presented.
Abstract Background Mismatch‐repair genes (MMRs) ensure high fidelity in genome editing. Loss of function mutation MMRs will lead to instability the and increase incidence cancers. Human mutL homolog 1 (MLH1) is a member MMRs, its found Lynch syndrome (LS). In addition colorectal cancer, LS patients often have other primary Here, case LS‐associated lung gastric double cancer was reported. Methods Diagnosis mainly based on clinical findings, imaging examination, histopathological data. The...
Objective Esophageal carcinoma (ESCA) is deadly cancer worldwide with unknown etiology. This study aimed to investigate the impact and mechanism of RAD6 on development squamous cell (ESCC).Expressions RAD6A RAD6B in ESCA were investigated from TCGA dataset their expressions tissue sample patients cells determined. Functional experiments conducted explore malignant characteristics several kinds ESCC cells. Animal experiment was established injected shRNA evaluate effect tumor growth.RAD6A...
Lung adenocarcinoma (LUAD) is currently one of the most common malignant tumors worldwide. However, there a lack long noncoding RNA (lncRNA)-based effective markers for predicting prognosis LUAD patients. We identified four lncRNAs that can effectively predict patients.We used data gene expression profile 446 patients from The Cancer Genome Atlas database. were randomly divided into training set and test set. Significant by univariate regression. Then, multivariate regression was to identify...
Objective: To explore the preparation and preliminary research on characteristics of modified nano-bioglass hydrogel. Methods: (1) The suspension was prepared by adding 67 mL nano-silica into 400 saturated calcium hydroxide solution, its stability observed. (2) hydrogel with final mass fraction 10% gelatin 1% sodium alginate set as control group. On basis in group, experiment added to prepare 0.5% bioglass, gelatin, alginate, experimental gelling time at 4 25 ℃and dissolution 37 ℃ 2 groups...
Objective To study the expression and mechanism of trihistidine nucleotide binding protein 1 in esophageal carcinoma. Methods The Eca-109 cancer cell line was cultured laboratory. The Hint1 vector expressed by pLVX-IRES-ZsCreen1 lentivirus. After 293T cells were purified concentrated, infected to obtain group cells. To detect green fluorescent (CFP) two groups, whether transfection successful or not, Western blotting method, detection invasiveness different groups Transwell invasion...
Abstract Background: Epstein-Barr virus (EBV) is suggested to actively utilize its EBV microRNAs (miRNAs) manipulate viral and cellular functions during neoplasia transformation. But role in tumor development maintenance remains unclear. The objective of this study examine EBV-miRNA-BART12 implicated associated carcinogenesis. Methods :Expression TPPP1 (Tubulin Polymerization Promoting Protein 1) was confirmed by GEO datasets, RT-PCR situ hybridization. Luciferase analyses, western blotting...