A5039797593- melanin and skin pigmentation
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Dermatology and Skin Diseases
- Retinopathy of Prematurity Studies
- Asthma and respiratory diseases
- Autophagy in Disease and Therapy
- Skin and Cellular Biology Research
- Cutaneous Melanoma Detection and Management
- Urticaria and Related Conditions
- Cytokine Signaling Pathways and Interactions
- Pregnancy and preeclampsia studies
- Retinal Diseases and Treatments
- Peroxisome Proliferator-Activated Receptors
- Dermatological and Skeletal Disorders
- PARP inhibition in cancer therapy
- NF-κB Signaling Pathways
- Monoclonal and Polyclonal Antibodies Research
- Cannabis and Cannabinoid Research
- Cancer and Skin Lesions
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Nonmelanoma Skin Cancer Studies
- Atherosclerosis and Cardiovascular Diseases
- Estrogen and related hormone effects
San Gallicano Hospital
2013-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Istituto Dermopatico dell'Immacolata
2004
Melasma is a hyperpigmentary disorder with photoaging features, whose manifestations appear on specific face areas, rich in sebaceous glands (SGs). To explore the SGs possible contribution to onset, expression of pro-melanogenic and inflammatory factors from SZ95 SG cell line exposed single or repetitive ultraviolet (UVA) radiation was evaluated. UVA up-modulated long-lasting production α-MSH, EDN1, b-FGF, SCF, cytokines mediators. Irradiated sebocyte conditioned media increased pigmentation...
Vitiligo is an acquired skin depigmentation disease involving multiple pathogenetic mechanisms, which ultimately direct cytotoxic CD8 + cells to destroy melanocytes. Abnormalities have been described in several even pigmented as expression of a functional inherited defect. Keratinocytes regulate homeostasis by the assembly proper barrier and releasing responding cytokines growth factors. Alterations epidermal proliferation, differentiation, lipid composition triggers for immune response...
Abstract Background In mouse models of retinopathy prematurity (ROP) inhibitors vascular endothelial growth factor (VEGF) functions administered systemically completely block retinal neovascularization. contrast, selective ocular VEGF depletion has achieved an approx. 50% inhibition neovascular growth. It is unclear whether a more complete new blood vessel development can be obtained with anti‐VEGF therapy localized to the eye. Therefore, objective present study was determine effect local in...
Derangement of the epidermal barrier lipids and dysregulated immune responses are key pathogenic features atopic dermatitis (AD). The Th2-type cytokines interleukin IL-4 IL-13 play a prominent role in AD by activating Janus Kinase/Signal Transduction Activator Transcription (JAK/STAT) intracellular signaling axis. This study aimed to investigate JAK/STAT lipid perturbations induced Th2 3D equivalents. Tofacitinib, low-molecular-mass JAK inhibitor, was used screen for JAK/STAT-mediated...
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor expressed in all skin cell types, plays key role physiological and pathological processes. Several studies have shown that this is involved the prevention of inflammatory diseases, e.g., psoriasis, atopic dermatitis, representing potential therapeutic target. We tested safety profile biological activity NPD-0614-13 NPD-0614-24, two new synthetic AhR ligands structurally related to natural agonist FICZ, known be...
Aim: B-cell lymphoma-2 (Bcl-2)-like protein-10 (Bcl2L10) is the less studied member of Bcl-2 family proteins, with controversial role in different cancer histotypes. Very recently, Bcl2L10 expression melanoma tumor specimens and its response to therapy have been demonstrated. Here, involvement on vitro vivo properties associated aggressive features has investigated. Methods: Endogenous protein was detected by western blotting analysis a panel patient-derived commercially available human...
Cutaneous squamous cell carcinoma (cSCC) is the most common UV-induced keratinocyte-derived cancer, and its progression characterized by epithelial–mesenchymal transition (EMT) process. We previously demonstrated that PPARγ activation 2,4,6-octatrienoic acid (Octa) prevents cutaneous UV damage. investigated possible role of activators Octa new compound (2Z,4E,6E)-2-methoxyocta-2,4,6-trienoic (A02) in targeting skin cancer. Like Octa, A02 exerted a protective effect against UVB-induced...
Atopic dermatitis (AD) is a chronic inflammatory disorder presenting dysregulated immune response and derangement of the epidermal barrier lipids. The Th2-type cytokines interleukin IL-4 IL-13 play prominent role in AD by activating Janus Kinase/Signal Transduction Activator Transcription (JAK/STAT) intracellular signal axis. This study aimed to investigate JAK/STAT lipid perturbations induced Th2 signaling 3D-epidermal equivalents. We used tofacitinib, low-molecular-mass JAK inhibitor,...
E7 protein from cutaneous as well mucosal HPV types can alter NF-κB activity. Conflicting literature data show a HPV-induced up- or down-regulation of the pathway in different cell lines. In previous study we detected expression gene HPV15 subungual tumour patient affected by incontinentia pigmenti (IP). IP is rare X-linked genodermatosis which IKKγ altered. From observations transgenic defective mice, it was suggested that IKK-deficient cells may undergo rapid hyper-proliferation and...
The endocannabinoid system regulates physiological processes, and the modulation of endogenous (eCB) levels is an attractive tool to contrast development pathological skin conditions including cancers. Inhibiting FAAH (fatty acid amide hydrolase), degradation enzyme anandamide (AEA) leads increase in AEA levels, thus enhancing its biological effects. Here, we evaluated anticancer property inhibitor URB597, investigating potential counteract epithelial-to-mesenchymal transition (EMT), a...