A5089222886- melanin and skin pigmentation
- Skin Protection and Aging
- Biochemical Analysis and Sensing Techniques
- Atherosclerosis and Cardiovascular Diseases
- Fibroblast Growth Factor Research
- Skin and Cellular Biology Research
- Dermatology and Skin Diseases
- RNA regulation and disease
- Autophagy in Disease and Therapy
- Mast cells and histamine
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Psoriasis: Treatment and Pathogenesis
- Wound Healing and Treatments
- Cardiac Valve Diseases and Treatments
- Animal health and immunology
- Acne and Rosacea Treatments and Effects
- Peroxisome Proliferator-Activated Receptors
- Cell Adhesion Molecules Research
- Cardiac tumors and thrombi
- Cardiac Imaging and Diagnostics
- Melanoma and MAPK Pathways
- Contact Dermatitis and Allergies
- Lysosomal Storage Disorders Research
San Gallicano Hospital
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Mount Sinai Hospital
2008-2023
Rosalind Franklin University of Medicine and Science
2008-2022
Mount Sinai Medical Center
2018-2022
Mount Sinai Hospital
2014-2022
Yale University
2006-2020
National Institutes of Health
2020
Harvard University
2020
Rockefeller University
2020
Background Cutaneous pigmentation is regulated by a complex melanogenic network in which both keratinocytes and fibroblasts synthesize growth factors cytokines. Solar lentigo (SL) characterized hyperpigmented lesions occurring on photodamaged skin areas. Despite the association of SL to ultraviolet (UV) exposure, mechanisms underlying development these spots are not completely defined. Objectives To analyse involvement fibroblast-derived factors, hepatocyte factor (HGF), keratinocyte (KGF)...
Combination therapy with BRAF and MEK inhibitors significantly improves survival in mutated melanoma patients but is unable to prevent disease recurrence due the emergence of drug resistance. Cancer stem cells (CSCs) have been involved these long-term treatment failures. We previously reported lung cancer that CSCs maintenance altered lipid metabolism dependent upon Stearoyl-CoA-desaturase (SCD1)-mediated upregulation YAP TAZ. On this ground, we investigated role SCD1 CSCs. gene expression...
Journal Article Inflammasome activation and vitiligo/nonsegmental vitiligo progression Get access J. Marie, Marie National Reference Centre for Rare Skin Diseases Hôpital St André CHU de Bordeaux France Search other works by this author on: Oxford Academic Google Scholar D. Kovacs, Kovacs IRCCS San Gallicano Dermatological Institute Rome Italy C. Pain, Pain FranceUniversity 146 rue Léo Saignat 33076 FranceINSERM U1035 Biothérapie des Maladies Génétiques et Cancers T. Jouary, Jouary Cota,...
Abstract Background Infective endocarditis (IE) is associated with high rates of mortality. Prolonged treatments high-dose intravenous antibiotics often fail to eradicate the infection, frequently leading high-risk surgical intervention. By providing a mechanism antibiotic tolerance, which escapes conventional susceptibility profiling, microbial biofilm represents key diagnostic and therapeutic challenge for clinicians. This study aims at assessing rapid identification assay targeted...
Solid tumors are complex systems characterized by dynamic interactions between neoplastic cells, non-tumoral and extracellular components. Among all the stromal cells that populate tumor microenvironment, fibroblasts most abundant elements critically involved in disease progression. Cancer-associated (CAFs) have pleiotropic functions growth matrix remodeling implicated local invasion distant metastasis. CAFs additionally participate inflammatory response of site releasing a variety...
Methicillin-resistant Staphylococcus aureus (MRSA) has become the leading cause of skin and soft tissue infections (SSTIs). Biofilm production further complicates patient treatment, contributing to increased bacterial persistence antibiotic tolerance. The study aimed explore efficacy different antibiotics on biofilm-producing MRSA isolated from patients with SSTI. A total 32 strains were collected MIC minimal biofilm eradication concentration (MBEC) measured in planktonic growth. showed that...
// Daniela Kovacs 1 , Emilia Migliano 2 Luca Muscardin 3 Vitaliano Silipo 4 Caterina Catricalà Mauro Picardo Barbara Bellei Laboratory of Cutaneous Physiopathology and Integrated Center Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy Department Plastic Reconstructive Surgery, Dermatopathological Laboratory, Oncologic Dermatology, Correspondence to: Bellei, email: bellei@ifo.it Keywords: WNT/β-catenin, melanoma heterogeneity, proliferation, metastases Received:...
Vitiligo is characterized by death or functional defects of epidermal melanocytes through still controversial pathogenic process. Previously, we showed that mitochondria-driven pre-senescent phenotype diminishes the capability vitiligo to cope with stressful stimuli. In current study, investigated markers mitochondrial energy metabolism including PGC1a axis, and then determined index impairment using a cytomic approach. We found in cultured melanocytes, compared healthy ones, low ATP,...
Bioassay-guided fractionation of the methanol extract shoots Myrsine africana led to isolation new compound myricetin 3-O-(2″,4″-di-O-acetyl)-α-l-rhamnopyranoside (9) and 11 known compounds. The compounds quercetin 3-O-(3″,4″-di-O-acetyl)-α-l-rhamnopyranoside (8), rutin (10), 3-O-α-l-rhamnopyranoside (11), (12) are reported for first time from M. africana. Compounds 10 12 showed significant inhibition tyrosinase with 50% (IC50 values) enzyme at 0.13 ± 0.003 0.12 0.002 mM, respectively, which...
Vitiligo is an acquired skin depigmentation disease involving multiple pathogenetic mechanisms, which ultimately direct cytotoxic CD8 + cells to destroy melanocytes. Abnormalities have been described in several even pigmented as expression of a functional inherited defect. Keratinocytes regulate homeostasis by the assembly proper barrier and releasing responding cytokines growth factors. Alterations epidermal proliferation, differentiation, lipid composition triggers for immune response...
Abnormalities of keratinocyte differentiation and impairment permeability barrier are features inflammatory skin diseases driven by Th1/Th17 Th2 immune response, such as psoriasis atopic dermatitis. We aimed at identifying the signature environments on keratinocytes, focusing expression genes involved in lipid metabolism profiles abundance metabolites. Human immortalized keratinocytes prodifferentiative conditions induced increasing calcium concentration, 3D epidermal equivalents were...
Decitabine, an epigenetic modifier that reactivates genes otherwise suppressed by DNA promoter methylation, is effective for some, but not all cancer patients, especially those with solid tumors. It commonly recognized to overcome resistance and improve outcome, treatment should be guided tumor biology, which includes genotype, epigenotype, gene expression profile. We therefore took integrative approach better understand melanoma cell response clinically relevant dose of decitabine identify...
Summary Given the importance of tanning response in protecting human skin from harmful effects UV radiation, one important research priority is to identify novel molecules that are capable promoting pigmentation and/or antioxidant defence. Parrodienes share some structural features with carotenoids and retinoids, stimulate cell defence counteract senescence‐like phenotype fibroblasts. We selected parrodiene‐derivative 2,4,6‐octatrienoic acid (Octa) study its impact on key parameters...
Abstract Azelaic acid (AzA) has been used for the treatment inflammatory skin diseases, such as acne and rosacea. Interestingly, an improvement in texture observed after long‐time with AzA. We previously unrevealed that anti‐inflammatory activity of AzA involves a specific activation PPARγ, nuclear receptor plays relevant role inflammation even ageing processes. As rosacea considered photo‐aggravated disease, we investigated ability to counteract stress‐induced premature cell senescence...