A5008008655- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Viral-associated cancers and disorders
- Spondyloarthritis Studies and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Multiple Sclerosis Research Studies
- Urticaria and Related Conditions
- Peripheral Neuropathies and Disorders
- Cell Adhesion Molecules Research
- Cutaneous lymphoproliferative disorders research
- Polyomavirus and related diseases
- Diabetic Foot Ulcer Assessment and Management
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Celiac Disease Research and Management
- Nail Diseases and Treatments
- Systemic Sclerosis and Related Diseases
- Cytomegalovirus and herpesvirus research
- Antimicrobial Resistance in Staphylococcus
- Liver Diseases and Immunity
- Chemokine receptors and signaling
- CNS Lymphoma Diagnosis and Treatment
Istituti di Ricovero e Cura a Carattere Scientifico
2004-2024
San Gallicano Hospital
2015-2024
Istituti Fisioterapici Ospitalieri
2019
Classical Kaposi's Sarcoma (cKS) is a rare vascular tumor, which develops in subjects infected with Human Herpesvirus-8 (HHV-8). Beside the host predisposing factors, viral genetic variants might possibly be related to disease development. The aim of this study was identify HHV-8 patients cKS or either asymptomatic cKS-unrelated cutaneous lymphoproliferative disorders.The VR1 and VR2 regions ORF K1 sequence were analyzed samples (peripheral blood and/or lesional tissue) collected between...
<i>Background:</i> To evaluate the modifications of circulating angiogenic factors, metalloproteinases and acute-phase cytokines after first single zoledronic acid (ZA) intravenous infusion. <i>Experimental Design:</i>Eighteen consecutive breast cancer patients with bone metastases were evaluated for levels vascular endothelial growth factor (VEGF), basic fibroblast (bFGF), metalloproteinase 1 (MMP-1), 2 (MMP-2), interleukins 1β, 6 8 (IL-1β, IL-6, IL-8), interferon γ,...
Abstract Background Infective endocarditis (IE) is associated with high rates of mortality. Prolonged treatments high-dose intravenous antibiotics often fail to eradicate the infection, frequently leading high-risk surgical intervention. By providing a mechanism antibiotic tolerance, which escapes conventional susceptibility profiling, microbial biofilm represents key diagnostic and therapeutic challenge for clinicians. This study aims at assessing rapid identification assay targeted...
Biological therapies are a new breakthrough in the treatment of psoriasis and psoriatic arthritis (PsA). Among these, tumour necrosis factor (TNF)-alpha antagonists such as infliximab etanercept most promising TNF is considered to be essential driving cytokine cascade at sites cutaneous synovial inflammation this disease.To evaluate time-related response serum release during monotherapy assess levels order provide fast, minimally invasive tool monitor and/or predict efficacy anti-TNF-alpha...
Bacterial bloodstream infection (BSI) represents a significant complication in hematologic patients. However, factors leading to BSI and progression end-organ disease death are understood only partially. The study analyzes host microbial risk assesses their impact on development mortality. A total of 96 patients with hematological malignancies were included the study. Host-associated all causes mortality analyzed by multivariable logistic regression at 30 days after onset first neutropenic...
Abstract : Tumor necrosis factor‐α (TNF‐α) plays a central role in sustaining the inflammatory process skin as well joints of patients with psoriasis and psoriatic arthritis. In fact, biological therapies based on monoclonal antibodies against TNF‐α have been proven to be effective both arthropathy cutaneous symptoms disease. Among several effects produced by keratinocytes there is induction expression MMP‐9, matrix metalloproteinase (MMP) mainly monocytes macrophages. this article we refer...
Inflammation represents an early and key event in the development of both cutaneous psoriasis psoriatic arthritis. Compelling evidences indicate that production TNF-alpha plays a central role by sustaining inflammatory process skin as well joints. Among multiple effects produced on keratinocytes, induction matrix metalloproteinase-9 (MMP-9), collagenase implicated joint arthritis which acts angiogenesis promoting factor, might represent mechanism pathogenesis disease. Aims present study were...
Natalizumab, an anti-alpha4 integrin monoclonal antibody inhibiting the adhesion of lymphocytes to endothelium, is a widely accepted drug treatment for relapsing-remitting multiple sclerosis (RRMS). A peripheral increase T and B has already been observed as early effect. This retrospective observational study was aimed evaluate lymphocyte subsets during long-term follow-up. We included 23 RRMS patients treated with natalizumab at least 24-48 months who had pretreatment evaluation. Baseline...
Background . The therapeutic management of psoriasis includes conventional treatments as well the new generation highly effective TNF- α inhibitors. However, has proven to be a complex challenge and treatment failures are not uncommon. Thus, laboratory biomarkers disease progression/therapeutic efficacy may greatly help in clinical psoriasis. Aims To identify for monitoring Methods An observational study performed on 59 patients, presenting moderate severe psoriasis, undergoing with...
A significant proportion of HIV-infected patients experiencing a late diagnosis highlights the need to define immunological protocols able help clinicians in identifying at higher risk for failure. The aim study was evaluate feasibility easy cytometric tests defining effect antiretroviral treatment (cART) on homeostasis and predictive markers early immune recovery. Chronic HIV infected (n = 202) were enrolled prospective multicentric study, their profile studied before (w0) after 24 weeks...
<h3>Objective</h3> To investigate the prevalence of human herpesvirus 8 (HHV-8; Kaposi sarcoma–associated herpesvirus) infection in patients with lymphoproliferative skin diseases such as large-plaque parapsoriasis (LPP) and mycosis fungoides compared inflammatory cutaneous conditions or healthy control subjects. <h3>Design</h3> A survey study was undertaken 123 subjects various clinical conditions. <h3>Setting</h3> All had been seen Dermatology Department San Gallicano Institute, Rome,...
In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) undifferentiated connective tissue (UCTD), we have explored setting peripheral T regulatory (T reg) cells assessed an expanded profile autoantibodies in patients with SSc, including either limited (lcSSc) or diffuse (dcSSc) disease, presenting signs symptoms UCTD. A large panel serum antibodies directed towards nuclear, nucleolar, cytoplasmic antigens,...
Infections are among the most frequent and challenging events in diabetic foot ulcers (DFUs). Pathogenic bacteria growing biofilms within host tissue highly tolerant to environmental chemical agents, including antibiotics. The present study was aimed at assessing use of silver sulfadiazine (SSD) for wound healing infection control 16 patients with DFUs harboring biofilm-growing Staphylococcus aureus Pseudomonas aeruginosa. All received a treatment based on dressing protocol disinfection,...
Abstract Background Patients with human immunodeficiency virus (HIV) infection may present a large variety of skin manifestations, often associated significant morbidity. In turn, dermatological diseases represent an early sign HIV infection, particularly in resource‐limited settings. Objectives This study aimed to assess the spectrum and their potential value as clinical proxies for detection management rural region Ethiopia. Methods The was performed on population 67,161 patients attending...
Abstract: This study analyzes both the blister fluid (BF) and serum levels of IL‐7 TGF‐beta 1 in samples from 18 patients affected with bullous pemphigoid (BP). These cytokines clearly present lower concentrations ( P <0.001) BFs than sera (1/20 1/2, respectively). In contrast, TNF‐alpha, IL‐10 IL‐4 increased amounts that were 12, 12 17‐fold, respectively. Eighteen (and 10 suction BF) normal individuals also employed as control. Normal presented significantly BP, while no significant...
The purpose of this study is to evaluate blood cytokines and immunological parameters in psoriatic patients during long-term treatment with Etanercept. Forty-five subjects both sexes affected by psoriasis or without arthritis entered the were treated Etanercept according international standard protocols. Biochemical analysis was carried out at baseline follow-up every second month. In particular, following kept under control: antinuclear antibodies, anti-nDNA anti-histone cell count,...