A5000390348- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Dermatological diseases and infestations
- Wound Healing and Treatments
- Fungal Infections and Studies
- Dermatology and Skin Diseases
- Neutropenia and Cancer Infections
- Vector-borne infectious diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Research on Leishmaniasis Studies
- Parvovirus B19 Infection Studies
- Intraperitoneal and Appendiceal Malignancies
- Diabetic Foot Ulcer Assessment and Management
- Syphilis Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Fungal Biology and Applications
- Nail Diseases and Treatments
- Genital Health and Disease
- Monoclonal and Polyclonal Antibodies Research
- Salmonella and Campylobacter epidemiology
Istituti di Ricovero e Cura a Carattere Scientifico
2003-2024
Istituti Fisioterapici Ospitalieri
2019-2024
National Cancer Institute
2020
Accademia di Belle Arti di Frosinone
2019
Ospedale San Paolo
2019
San Gallicano Hospital
2002-2017
Instituto Nazionale Tumori Regina Elena
2017
Azienda Ospedaliera Ospedale Civile di Legnano
2012
Istituto Superiore di Sanità
2000-2001
Sapienza University of Rome
1991-1992
Bacterial biofilm is a major factor in delayed wound healing and high levels of production have been repeatedly described multidrug resistant organisms (MDROs). Nevertheless, quantitative correlation between the profile antimicrobial drug resistance remains to be determined. Microbial identification, antibiotic susceptibility were assessed 135 clinical isolates from 87 patients. Gram-negative bacteria most represented microorganisms (60.8%) with MDROs accounting for 31.8% total isolates....
Abstract Seborrheic dermatitis (SD) affects 2–5% of the global population, with imbalances in skin microbiome implicated its development. This study assessed impact an oily suspension containing Lactobacillus crispatus P17631 and Lacticaseibacillus paracasei I1688 (termed EUTOPLAC) on SD symptoms mycobiome-bacteriome modulation. 25 patients were treated EUTOPLAC for a week. Symptom severity changes measured at start treatment (T0), after seven days (T8), three weeks post-treatment (T28)....
Abstract Individuals with Atopic dermatitis (AD) are highly susceptible to Staphylococcus aureus colonization. However, the mechanisms driving this process as well impact of S. in AD pathogenesis still incompletely understood. In study, we analysed role biofilm sustaining chronic persistence and its on severity. Further explored whether key inflammatory cytokines overexpressed might provide a selective advantage . Results show that strength production by correlated severity skin lesion,...
Abstract Background Infective endocarditis (IE) is associated with high rates of mortality. Prolonged treatments high-dose intravenous antibiotics often fail to eradicate the infection, frequently leading high-risk surgical intervention. By providing a mechanism antibiotic tolerance, which escapes conventional susceptibility profiling, microbial biofilm represents key diagnostic and therapeutic challenge for clinicians. This study aims at assessing rapid identification assay targeted...
Methicillin-resistant Staphylococcus aureus (MRSA) has become the leading cause of skin and soft tissue infections (SSTIs). Biofilm production further complicates patient treatment, contributing to increased bacterial persistence antibiotic tolerance. The study aimed explore efficacy different antibiotics on biofilm-producing MRSA isolated from patients with SSTI. A total 32 strains were collected MIC minimal biofilm eradication concentration (MBEC) measured in planktonic growth. showed that...
Microbial biofilm represents a major virulence factor associated with chronic and recurrent infections. Pathogenic bacteria embedded in biofilms are highly resistant to environmental chemical agents, including antibiotics therefore difficult eradicate. Thus, reliable tests assess formation by bacterial strains as well the impact of chemicals or on represent desirable tools for most effective therapeutic management microbiological risk control. Current methods evaluate usually time-consuming,...
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a prominent cause of nosocomial infections associated with high rates morbidity and mortality, particularly in oncological patients. The hypermucoviscous (HMV) phenotype biofilm production are key factors for CRKP colonization persistence the host. This study aims at exploring impact virulence on mortality A total 86 were collected between January 2015 December 2019. Carbapenem resistance-associated genes, antibiotic susceptibility, HMV...
Bacterial bloodstream infection (BSI) represents a significant complication in hematologic patients. However, factors leading to BSI and progression end-organ disease death are understood only partially. The study analyzes host microbial risk assesses their impact on development mortality. A total of 96 patients with hematological malignancies were included the study. Host-associated all causes mortality analyzed by multivariable logistic regression at 30 days after onset first neutropenic...
Leishmaniasis is a worldwide disease, but due to the absence of surveillance systems under-reported from low- and middle-income countries. In Ethiopia, disease found in rural highlands incidence Leishmania/HIV co-infection increasing. Although some studies have been carried out areas country with similar disease/ecological profile this report is, our knowledge, first aimed at elucidating clinical-epidemiological features cutaneous mucocutaneous leishmaniasis Tigray, northern Ethiopia. This...
Summary Objective To assess the impact and feasibility of artemether‐lumefantrine deployment at community level, combined with phased introduction rapid diagnostic tests (RDTs), on malaria transmission, morbidity, mortality health service use in a remote area Ethiopia. Methods Two‐year pilot study two districts: was prescribed after parasitological confirmation facilities both districts. In intervention district, also made available through 33 workers (CHWs); these, 50% were equipped RDTs...
Ralstonia spp, an environmental microorganism, has been occasionally associated with healthcare infections. The aim of this study was to investigate outbreak caused by mannitolilytica in oncology patients. Case definition: Oncology outpatients attending a day ward, positive blood and/or central venous catheter (CVC) culture for spp from September 2013 – June 2014. We analysed medical records, procedures and samples. R. identified 16S rRNA sequencing, typed Pulsed Field Gel Electrophoresis...
Background: The modes of transmission HHV-8 are still unclear. Goal: To evaluate the distribution and infection. Design: Serosurvey conducted in a Cameroon hospital among 292 persons, including children (5-10 years), adolescents (15-20 adults (30-40 years). Antibodies against lytic latent antigens to were detected by immunofluorescence assay; antibodies Epstein-Barr virus viral enzyme-linked immunoabsorbent assay. Results: prevalence antilytic remained stable was 39.8% children, 51.5%...
Unlike allogeneic transplant, autologous stem cell transplantation (ASCT) represents a procedure with low-risk of cytomegalovirus (CMV) symptomatic reactivation-infection/end-organ disease (CMV complications) and invasive fungal (IFD). However, novel drugs for the treatment lymphoproliferative malignancies could cause an increase such opportunistic infections, even after ASCT. To best our knowledge, there are no published data demonstrating association between CMV IFD in setting, while this...
Infections are among the most frequent and challenging events in diabetic foot ulcers (DFUs). Pathogenic bacteria growing biofilms within host tissue highly tolerant to environmental chemical agents, including antibiotics. The present study was aimed at assessing use of silver sulfadiazine (SSD) for wound healing infection control 16 patients with DFUs harboring biofilm-growing Staphylococcus aureus Pseudomonas aeruginosa. All received a treatment based on dressing protocol disinfection,...
ABSTRACT Staphylococcus aureus is a predominant cause of infections in individuals with spinal cord stimulation (SCS) devices. Biofilm formation complicates these infections, commonly requiring both surgical and antibiotic treatments. This study explored the biofilm matrix composition antimicrobial susceptibility planktonic biofilm-growing S. isolates from SCS-related infections. Whole-genome sequencing (WGS) examined genotypes, virulome, resistome, pan-genome structure. The also analyzed...
Which are the essential global public health activities that should be carried out in order to attain largest impact on poverty reduction and improvement world? Since its foundation 2001 Human Mobile Population Committee (HMPC) has continued devote efforts finding answers this question, with a particular focus skin diseases of (HMP) other groups disadvantaged people. In article we present model socio-sanitary activity field Migration, Poverty Health Department Preventive Medicine Tourism...