A5048381192- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Viral-associated cancers and disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Spondyloarthritis Studies and Treatments
- Cutaneous lymphoproliferative disorders research
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Polyomavirus and related diseases
- Multiple Sclerosis Research Studies
- Autoimmune and Inflammatory Disorders Research
- Cytokine Signaling Pathways and Interactions
- Contact Dermatitis and Allergies
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Histiocytic Disorders and Treatments
- Rheumatoid Arthritis Research and Therapies
- Food Allergy and Anaphylaxis Research
- Systemic Sclerosis and Related Diseases
San Gallicano Hospital
2007-2018
Istituti di Ricovero e Cura a Carattere Scientifico
1998-2016
GTx (United States)
1999
New York Medical College
1988
Scripps Health
1981
Scripps Clinic
1981
Istituto di Sessuologia Clinica
1980
Classical Kaposi's Sarcoma (cKS) is a rare vascular tumor, which develops in subjects infected with Human Herpesvirus-8 (HHV-8). Beside the host predisposing factors, viral genetic variants might possibly be related to disease development. The aim of this study was identify HHV-8 patients cKS or either asymptomatic cKS-unrelated cutaneous lymphoproliferative disorders.The VR1 and VR2 regions ORF K1 sequence were analyzed samples (peripheral blood and/or lesional tissue) collected between...
Biological therapies are a new breakthrough in the treatment of psoriasis and psoriatic arthritis (PsA). Among these, tumour necrosis factor (TNF)-alpha antagonists such as infliximab etanercept most promising TNF is considered to be essential driving cytokine cascade at sites cutaneous synovial inflammation this disease.To evaluate time-related response serum release during monotherapy assess levels order provide fast, minimally invasive tool monitor and/or predict efficacy anti-TNF-alpha...
The NC16A immunodominant region of the bullous pemphigoid (BP) antigen BP180 has been used to develop several enzyme-linked immunosorbent assays (ELISAs) as diagnostic tools for BP autoantibody detection.Because reactivity is not restricted NC16A, we have investigated possibility developing an ELISA based on selected epitopes additional this region.Initially 78 sera were tested using and IgG was detected in 64 (82%). 14 NC16A-negative then analysed by immunological screening against seven...
Abstract BACKGROUND Classic Kaposi sarcoma (CKS) is an inflammatory‐mediated neoplasm that develops in the presence of KS‐associated herpesvirus (KSHV) and immune perturbation. In current study, authors compared CKS cases with age‐matched sex‐matched KSHV‐seropositive controls without human immunodeficiency virus‐1 infection markers viral control, blood counts, CD4‐positive CD8‐positive lymphocytes, serum β‐2‐microglobulin neopterin levels. METHODS Viral loads were detected using real‐time...
Human T-cell leukemia virus (HTLV-1) is a lymphotropic retrovirus associated to adult T cell (ATL) and non-neoplastic inflammatory conditions affecting the central nervous system, lung or skin. The disorders HTLV-1 are mediated by different proinflammatory cytokines as IL-1α, IL-6, TNF-α. release role of IL-17 still debated. Aims this study were analyze induction infection determine whether resveratrol (RES) able down regulate pathway production either in chronically infected MT-2 line human...
Abstract : Tumor necrosis factor‐α (TNF‐α) plays a central role in sustaining the inflammatory process skin as well joints of patients with psoriasis and psoriatic arthritis. In fact, biological therapies based on monoclonal antibodies against TNF‐α have been proven to be effective both arthropathy cutaneous symptoms disease. Among several effects produced by keratinocytes there is induction expression MMP‐9, matrix metalloproteinase (MMP) mainly monocytes macrophages. this article we refer...
Recent attempts to diminish nickel use in most industrial products have led an increasing utilization of alternative metal compounds for destinations such as the alloys used orthopaedics, jewellery and dentistry. The present study was undertaken with aim evaluate potential allergic response nickel, palladium rhodium on basis antigen-specific induction inflammatory/regulatory cytokines, characterize, according cytokine profiles, nature simultaneous positive patch tests elicited vivo....
Inflammation represents an early and key event in the development of both cutaneous psoriasis psoriatic arthritis. Compelling evidences indicate that production TNF-alpha plays a central role by sustaining inflammatory process skin as well joints. Among multiple effects produced on keratinocytes, induction matrix metalloproteinase-9 (MMP-9), collagenase implicated joint arthritis which acts angiogenesis promoting factor, might represent mechanism pathogenesis disease. Aims present study were...
S. aureus represents a critical cofactor in atopic dermatitis (AD). In this paper, the prevalence of infection/colonization was evaluated 117 children as well their cohabitants, order to assess value characterization predicting disease onset and severity providing indications for prophylaxis. Results showed that with AD cohabitants had significantly greater incidence compared controls. The genetic virtual identity bacteria strains collected at different sites patients those found suggesting...
The present prospective study was aimed at evaluating the long-term efficacy of local electrochemotherapy (ECT) with intravenous administration bleomycin, on disease progression and viral activity in classic Kaposi's sarcoma (cKS), a vascular tumor related to human herpes virus-8 infection. Eighteen patients affected by isolate or multiple cutaneous lesions, refractory conventional treatments, although absence visceral involvement, were enrolled study. Follow-up visits performed after 4...
Natalizumab, an anti-alpha4 integrin monoclonal antibody inhibiting the adhesion of lymphocytes to endothelium, is a widely accepted drug treatment for relapsing-remitting multiple sclerosis (RRMS). A peripheral increase T and B has already been observed as early effect. This retrospective observational study was aimed evaluate lymphocyte subsets during long-term follow-up. We included 23 RRMS patients treated with natalizumab at least 24-48 months who had pretreatment evaluation. Baseline...
Abstract: We investigated the relationship between eight polymorphisms in gene encoding for vascular endothelial growth factor (VEGF) (−1540C > A, −1512Ins18, −1451C T, −460T C, −160C −152G −116G A and +405G C) plaque‐type psoriasis stratified age at onset, gender family history of dermatosis. For this purpose, 117 patients with chronic 215 healthy subjects were enrolled. found that being homozygous −1540AA, −1512InsIns, −1451TT, −460CC −152AA conferred a significant risk developing...
Background . The therapeutic management of psoriasis includes conventional treatments as well the new generation highly effective TNF- α inhibitors. However, has proven to be a complex challenge and treatment failures are not uncommon. Thus, laboratory biomarkers disease progression/therapeutic efficacy may greatly help in clinical psoriasis. Aims To identify for monitoring Methods An observational study performed on 59 patients, presenting moderate severe psoriasis, undergoing with...
<h3>Objective</h3> To investigate the prevalence of human herpesvirus 8 (HHV-8; Kaposi sarcoma–associated herpesvirus) infection in patients with lymphoproliferative skin diseases such as large-plaque parapsoriasis (LPP) and mycosis fungoides compared inflammatory cutaneous conditions or healthy control subjects. <h3>Design</h3> A survey study was undertaken 123 subjects various clinical conditions. <h3>Setting</h3> All had been seen Dermatology Department San Gallicano Institute, Rome,...
Tryptase and myeloperoxidase respectively represent 2 specific markers of activated mast cells or neutrophils. Therefore, establishing the levels these enzymes may be useful to quantify cell involvement in tissues fluids different origins pathologies. The aim this study was analyse both sera blister patients affected with bullous pemphigoid. These were then correlated concentrations 19 cytokines soluble adhesion molecules determined same samples also log (anti-basement membrane zone...
In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) undifferentiated connective tissue (UCTD), we have explored setting peripheral T regulatory (T reg) cells assessed an expanded profile autoantibodies in patients with SSc, including either limited (lcSSc) or diffuse (dcSSc) disease, presenting signs symptoms UCTD. A large panel serum antibodies directed towards nuclear, nucleolar, cytoplasmic antigens,...
Abstract: This study analyzes both the blister fluid (BF) and serum levels of IL‐7 TGF‐beta 1 in samples from 18 patients affected with bullous pemphigoid (BP). These cytokines clearly present lower concentrations ( P <0.001) BFs than sera (1/20 1/2, respectively). In contrast, TNF‐alpha, IL‐10 IL‐4 increased amounts that were 12, 12 17‐fold, respectively. Eighteen (and 10 suction BF) normal individuals also employed as control. Normal presented significantly BP, while no significant...
Journal Article Use of Discriminant Analysis to Assess Disease Activity in Pulmonary Tuberculosis with a Panel Specific and Nonspecific Serum Markers Get access Franco Ameglio, MD, MD 1 From the Laboratory Clinical Pathology, S. Gallicano Institute, Rome, Italy. Search for other works by this author on: Oxford Academic Google Scholar Diana Giannarelli, SD, SD 2 Statistics Epidemiology, Regina Elena Institute Cancer Research, Paola Cordiali-Fei, PhD, PhD Mario Pietravalle, Lucilla Alemanno,...