A5032257112- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Photochromic and Fluorescence Chemistry
- Photoreceptor and optogenetics research
- Chemical Synthesis and Analysis
- Retinal Development and Disorders
- Inorganic Chemistry and Materials
- Synthesis and characterization of novel inorganic/organometallic compounds
- Synthesis of Tetrazole Derivatives
- Crystallography and molecular interactions
- Molecular Sensors and Ion Detection
- Click Chemistry and Applications
- Energetic Materials and Combustion
- Thermal and Kinetic Analysis
- Organometallic Complex Synthesis and Catalysis
- Radical Photochemical Reactions
- Luminescence and Fluorescent Materials
- Supramolecular Self-Assembly in Materials
- Pharmacological Effects and Assays
- Nicotinic Acetylcholine Receptors Study
- Silicone and Siloxane Chemistry
- Chemical Reactions and Mechanisms
- Receptor Mechanisms and Signaling
- Lipid Membrane Structure and Behavior
- Amino Acid Enzymes and Metabolism
New York University
2018-2023
Ludwig-Maximilians-Universität München
2012-2022
Center for Integrated Protein Science Munich
2015-2021
University of St Andrews
2015
Azobenzenes are versatile photoswitches that have found widespread use in a variety of fields, ranging from photopharmacology to the material sciences. In addition regular azobenzenes, cyclic diazocines recently emerged. Although fascinating conformational and photophysical properties, their has been limited by synthetic accessibility. Herein, we present general, high-yielding protocol relies on oxidative cyclization dianilines. combination with modular substrate synthesis, it allows for...
Nicotinic acetylcholine receptors (nAChRs) are essential for cellular communication in higher organisms. Even though a vast pharmacological toolset to study cholinergic systems has been developed, control of endogenous neuronal nAChRs with high spatiotemporal precision lacking. To address this issue, we have generated photoswitchable nAChR agonists and re-evaluated the known photochromic ligand, BisQ. Using electrophysiology, found that one our new compounds, AzoCholine, is an excellent...
Retinal degenerative diseases can have many possible causes and are currently difficult to treat. As an alternative therapies that require genetic manipulation or the implantation of electronic devices, photopharmacology has emerged as a viable approach restore visual responses. Here, we present new photopharmacological strategy relies on photoswitchable excitatory amino acid, ATA. This freely diffusible molecule selectively activates AMPA receptors in light-dependent fashion. It primarily...
A modification of the synthesis sodium 5,5′-azotetrazolate pentahydrate, described by Thiele in 1898, yields unknown and unexpected corresponding 5N-oxido derivative 5,5′-azoxybistetrazolate pentahydrate (Na2zTO·5H2O, 1). Purification was achieved recrystallization based on better solubility Na2zTO·5H2O water. Different nitrogen-rich salts, such as diammonium (3), dihydroxylammonium (4), bis-diaminoguanidinium (5), bis-triaminoguanidinium (6) diaminouronium salt (7), have been prepared using...
A comprehensive investigation of reactions alkali-metal derivatives the ditelluro dianion [TePV(NtBu)(μ-NtBu)]22– (L2–, E = Te) with p-block element halides produced a series novel heterocycles incorporating P2VN2 rings, tellurium, and group 13–16 elements. The engages in Te,Te′-chelation to metal center Ph2Ge R2Sn (R tBu, nBu, Ph) derivatives; similar behavior was noted for 14 L2– (E S, Se). In case 13 trihalides MCl3 (M Ga, In), neutral spirocyclic complexes...
Metathetical reactions of alkali-metal derivatives the dianion [(t)BuN(Se)P(μ-N(t)Bu)2P(Se)N(t)Bu](2-) ((2Se2-)) with Ag(NHC)Cl, Ag[BF4], AuCl(THT) and HgCl2, as well reaction 2S(2-) were investigated. The observed products all incorporate monoprotonated ligands 2SeH(-) or 2SH(-) in a variety structural arrangements around metal centres, including tetrameric trimeric macrocycles [Ag Au (E = Se)], ladder (Au, E S) spirocycle (Hg); contains both monoanion linking three Au2 units. All complexes...
Photopharmacology has yielded compounds that have potential to restore impaired visual responses resulting from outer retinal degeneration diseases such as retinitis pigmentosa. Here we evaluate two photoswitchable azobenzene ion channel blockers, DAQ and DAA for vision restoration. exerts its effect primarily on RGCs, whereas induces light-dependent spiking through amacrine cell activation. Degeneration-induced local field potentials remain a major challenge common all restoration...
Abstract Photopharmacology relies on ligands that change their pharmacodynamics upon photoisomerization. Many of these are azobenzenes thermodynamically more stable in elongated trans ‐configuration. Often, they biologically active this form and lose activity irradiation photoisomerization to cis ‐isomer. Recently, cyclic azobenzenes, so‐called diazocines, have emerged, which bent ‐form. Incorporation switches into a variety photopharmaceuticals could convert dark‐active dark‐inactive...
Adenosine receptors (ARs) play many important roles in physiology and have been recognized as potential targets for pain relief. Here, we introduce three photoswitchable adenosine derivatives that function light-dependent agonists ARs confer optical control to these G protein-coupled receptors. One of our compounds, AzoAdenosine-3, was evaluated the classical formalin model pain. The molecule, active dark, not metabolized by deaminase effectively reduced perception a manner. These...
A new heterocycle consisting of a tetrazole ring attached to an amino‐triazolone ring, namely 5‐(4‐amino‐1,2,4‐triazol‐3‐on‐5′‐yl)‐1 H ‐tetrazole ( 3 ) as well its ammonium 2 ), hydroxylammonium and sodium salt 4 is introduced. Its formed starting from tetrazole‐5‐carboxamide oxime 1 which reacted with diaminourea (carbonyldihydrazide) in aqueous media. All compounds , 5 were structurally characterized by single crystal X‐ray diffraction. The thermal behavior was investigated using...
Azo compounds are efficient electron acceptors. Upon one-electron reduction they generally isomerize forming the thermodynamically most stable radical anion. Herein we show that size of central ring in 1,2-diazocines and diazonines has a ruling influence on configuration reduced species. Markedly, diazonines, which bear nine membered heterocycle, light-induced E/Z isomerization, but retain diazene N=N moiety upon reduction. Accordingly, isomerization is not induced by
Fluorescent protein biomaterials have important applications such as bioimaging in pharmacological studies. Self-assembly of proteins, especially into fibrils, is known to produce fluorescence the blue band. Capable self-assembly nanofibers, we shown can modulate its aggregation mesofibers by encapsulation a small hydrophobic molecule. Conversely, azobenzenes are molecules that virtually non-fluorescent solution due their highly efficient photoisomerization. However, they demonstrate...
Photopharmacology relies on ligands that change their pharmacodynamics upon photoisomerization. Many of these are azobenzenes thermodynamically more stable in elongated <i>trans</i>configuration, which predominates the dark. Often, they biologically active this form and lose activity irradiation photoisomerization to <i>cis</i>-isomer. Recently, cyclic azobenzenes, so-called diazocines, have emerged. They bent <i>cis</i>‑form than...