A5036686567- Neonatal Respiratory Health Research
- Kawasaki Disease and Coronary Complications
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- COVID-19 Impact on Reproduction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cystic Fibrosis Research Advances
- Pneumonia and Respiratory Infections
- Spondyloarthritis Studies and Treatments
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- COVID-19 Clinical Research Studies
- Autoimmune and Inflammatory Disorders Research
- Child and Adolescent Health
- Human Health and Disease
- Air Quality and Health Impacts
- Tracheal and airway disorders
- Parvovirus B19 Infection Studies
- Immune cells in cancer
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiovascular Issues in Pregnancy
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
Peoples' Friendship University of Russia
2021-2024
City Clinical Hospital
2024
Mycoplasma pneumoniae ( M. pn. ), which is a well-known pathogen to cause atypical pneumonia, in 25% of cases can lead wide range extra-pulmonary symptoms, reflecting damage almost any organ or system (skin and mucous membranes, nervous, cardiovascular, gastrointestinal, urinary etc.). Aspecific syndrome -induced rash mucositis (MIRM) has been identified recently. Among the CNS manifestations associated with , acute postinfectious cerebellar ataxia worth mentioning. In this article we...
Despite the manifestations of primary ciliary dyskinesia (PCD) in neonatal period or first year life, diagnosis this rare disease is usually established at age 4–7 years. The aim study was to search for reserves early PCD. Materials and methods research: 17 patients were observed with PCD, confirmed on basis PICADAR scale, highspeed light video microscopy (all patients) transmission electron (in 3 mucous biopsy respiratory membrane using a genetic one patient). Results: all born full-term;...
Coronavirus disease 2019 (COVID-19) in children most cases is asymptomatic or mild, and its severe late complication multisystem inflammatory syndrome (MIS-C). The aim of the study to find clinical, laboratory instrumental characteristics, description therapeutic tactics, including determination profile patients requiring Tocilizumab prescription outcomes MIS-C associated with COVID-19. Materials methods research: 245 aged 3 months – 17 years old were included pilot prospective multicenter...
Organizing pneumonia (OP) is an interstitial lung disease (ILD), which characterized by the proliferation of granulation tissue in bronchioles and alveoli, diagnosed on basis clinical history, morphological data, CT changes response to glucocorticoid (GC) therapy. Information about OP children limited due insufficient number cases described observed. The purpose this research was establish epidemiological characteristics, etiological structure, semiotics children, characterize its...
The most severe manifestation of the new coronavirus infection COVID-19 in children is multisystem inflammatory syndrome (MIS-C). A systematic review foreign publications as July 25, 2020 contains an analysis disease course 662 with this and used for comparison data obtained. Objective research: to characterize clinical manifestation, results laboratory instrumental studies, therapy, outcomes consequences COVID-19- associated MIS-C, based on observation patients hospitalized Morozov...
The review is devoted to a highly relevant problem – the impact of polluted air on respiratory health child population. main pollutants (pollutants) in both urban and rural areas, depth their penetration into tract are analyzed detail; evidence given an increased risk infections exacerbations bronchial asthma children living large cities. following issues were discussed: controlled exposure infections; mechanisms negative effects lungs; reducing pollution able improve human health? It should...
Background. Primary ciliary dyskinesia (PCD) is an orphan disease, and diagnosis difficult because there no gold standard for diagnosis. Aim. Clinical, laboratory-instrumental, genetic characteristics of PCD in children. Materials methods. From 2009 to 2024, 31 patients with a genetically confirmed were observed as part multicenter, open-ended, descriptive pilot longitudinal study. Examination methods: clinical anamnestic method; X-ray examination computed tomography the chest organs...
Objective . To study the characteristics of severe acute bronchiolitis (AB) caused by hMPV (hMPV-AB). Materials and Methods: This retrospective comparative included 27 patients aged 2 to 12 months, who were hospitalized from 2021 2023 in Intensive Care Unit (ICU) «Kommunarka» Moscow Multidisciplinary Clinical Center. The etiology AB was determined using polymerase chain reaction. Results Patients with hMPV-AB had a longer stay ICU compared another (9.0 [5.0; 11.0]; 3,0 [2.0; 4.0] days, p =...
Macrophage (Mph) polarization and functional activity play an important role in the development of inflammatory lung conditions. The previously widely used bimodal classification Mph into M1 M2 does not adequately reflect full range changes diversity observed response to various stimuli disease states. Here, we have developed a model for direct assessment from bronchial alveolar lavage fluid (BALF) alterations, terms phagocytosis activity, depending on external stimuli, such as exposure...
Background. Primary ciliary dyskinesia (PCD) is an orphan disease, and diagnosis difficult because there no gold standard for diagnosis. Aim. Clinical, laboratory-instrumental, genetic characteristics of PCD in children. Materials methods. From 2009 to 2024, 31 patients with a genetically confirmed were observed as part multicenter, open-ended, descriptive pilot longitudinal study. Examination methods: clinical anamnestic method; X-ray examination computed tomography the chest organs...
The review, based on modern literature data and the results of many years research conducted by authors, highlights problem comorbidity (multimorbidity) in children with bronchial asthma (BA). There is a grouping concomitant diseases depending type (causal, complicated, unspecified, reverse). Based epidemiological data, observational cohort studies, systematic reviews meta-analyses, information frequency BA various comorbid was summarized. Scientific, theoretical practical significance BA,...
Frequency of development and characteristics the course bronchial asthma (BA) in premature infants with bronchopulmonary dysplasia (BPD) remains controversial problem as yet. In particular, there is insufficient data on predictors BA children BPD. The purpose this research was to find for Materials methods used: a single-center retrospective (2004 2023) cohort study 1724 records pediatric patients aged 3 months 18 years old history used clinical anamnestic method, determination number...
Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a rare life-threatening immunopathological complication of that develops 1-6 weeks after the acute coronavirus infection. MIS-C characterized by fever and multiorgan inflammation.We present clinical case 10-year-old boy skin lesions at onset (erythematous malar rash, lacelike rash on trunk extremities petechiae) macrophage activation development early stage primary Epstein-Barr virus infection (EBV infection)...
The article presents a review of cross-sectional studies and long-term prospective observations dedicated to changes in bone mineral density (BMD) patients with rheumatoid arthritis (RA) factors influencing it. relationship between local loss (erosion count) generalized BMD was noted. It is indicated that existing RA treatment strategies are aimed at suppressing inflammation rather than preventing resorption. There evidence anti-inflammatory therapy using glucocorticoids, methotrexate,...