A5101815256- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Neuroblastoma Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Sulfur Compounds in Biology
- Cancer-related gene regulation
- Molecular Sensors and Ion Detection
- Cytokine Signaling Pathways and Interactions
- Thyroid Disorders and Treatments
- Glutathione Transferases and Polymorphisms
- Heat shock proteins research
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Cancer therapeutics and mechanisms
- Galectins and Cancer Biology
- Signaling Pathways in Disease
- Cancer Cells and Metastasis
- Genomics, phytochemicals, and oxidative stress
- Ginseng Biological Effects and Applications
- DNA Repair Mechanisms
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
Hebei Medical University
2015-2025
Second Hospital of Hebei Medical University
2015-2025
Wuxi People's Hospital
2022
Nanjing Medical University
2022
Hubei University of Chinese Medicine
2020
Background: The most prevalent extracranial solid tumor in childhood is neuroblastoma (NB), which arises from undifferentiated neural crest cells. However, the prognosis of this condition remains unfavorable, and underlying mechanisms its origin are still elusive. Therefore, study aimed to investigate specific mechanism NEAT1-1 NB. Methods: In study, expressions NEAT1-1, miR-873-5p, GalNAcT-I were analyzed by real-time quantitative polymerase chain reaction (qRTPCR) Western blot (WB). Then,...
Abstract Quercetin is a plant flavonoid and has antioxidative properties. In this study, we evaluated the therapeutic effect of quercetin on thyroid dysfunction in L‐thyroxin (LT4)‐induced hyperthyroidism rats. LT4 was used to prepare experimental model via intraperitoneal injection. injected at series doses (5, 50, 100 mg/kg) LT4‐induced hypothyroidism rats once day for 14 days. The body weight food intake were measured week. levels hormones, liver function, oxidative stress markers,...
A previous RNA interference (RNAi) screen identified filamin (FLNA) as a potential biomarker to predict chemosensitivity in triple-negative breast cancer (TNBC). However, its ability modulate and the underlying mechanism has not been investigated. Genetic manipulation of FLNA expression performed an immortalized noncancerous human mammary epithelial cell line four TNBC lines investigate effect on chemosensitivity. Western blot analysis was identify signaling pathway involved. Xenograft mouse...
Papillary Thyroid Carcinoma (PTC) represents the most common thyroid cancer. Until recently, treatment options for PTC patients are limited. Nilotinib is second-generation tyrosine kinase inhibitor, and has been widely used in of Chronic Myeloid Leukemia (CML).We aimed to explore whether nilotinib effective suppression cancer progression underlying mechanisms.In this study, three human cell lines (KTC-1, BCPAP, TPC1) were verify effects on growth. The half maximal inhibitory concentration...
Vascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion. The prognostic value of VAP-1 has been determined in gastric cancer. aim this study was to evaluate the changes and predictive serum patients with thyroid A total 126 nodules 53 healthy controls participated study. were further divided into subgroup 1 (69 cases benign nodules) 2 (57 cancer). Serum measured by time-resolved immunofluorometric assay. Diagnostic presurgical for cancer...
Abstract Background High agglomeration of myeloid-derived suppressor cells (MDSCs) in neuroblastoma (NB) impeded therapeutic effects. This study aimed to investigate the role and mechanism targeted inhibition MDSCs by low-dose doxorubicin (DOX) enhance immune efficacy NB. Methods Bagg albino (BALB/c) mice were used as tumor-bearing mouse models injecting Neuro-2a cells, eliminated DOX or dopamine (DA) administration. Tumor-bearing randomly divided into 2.5 mg/kg DOX, 5.0 50.0 DA, control...
Abstract Background: Panax notoginseng is a highly valuable medicinal plant. Reduced P. yield common and serious problem that arises in continuous cropping system. Variation the composition function of soil microbial community considered primary cause reduction. Methods: This study used shotgun metagenomic sequencing approaches to describe taxonomic functional features rhizosphere microbiome screen taxa traits related yields. Results: At family genus level, total 43 families 45 genera...