A5092593216- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Mitochondrial Function and Pathology
- Advanced MRI Techniques and Applications
- Gene Regulatory Network Analysis
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Genetics, Aging, and Longevity in Model Organisms
- Neurological disorders and treatments
University of Antwerp
2024-2025
Huntington's disease (HD) is a progressive neurodegenerative affecting motor and cognitive abilities. Multiple studies have found white matter anomalies in HD-affected humans animal models of HD. The identification sensitive white-matter-based biomarkers HD will be important understanding mechanisms testing the efficacy therapeutic interventions. Here we investigated progression deficits knock-in zQ175DN heterozygous (HET) mouse model at 3, 6 11 months age (M), reflecting different states...
Huntington’s disease (HD) is a neurodegenerative disorder for which no cure available. There an urgent need to find early biomarkers are sensitive enough determine and follow up the efficacy of novel therapies. In this study, we present outcome treatment study in LacQ140 HD mouse model using diffusion tensor/kurtosis imaging (DTI/DKI) fixel-based analysis (FBA). We observed that early, moderate lowering mutant Huntingtin (mHtt) rescues structural alterations measured with MRI olfactory bulb...
Dynamic analyses of resting-state (RS) fMRI reveal transient constituents RS networks such as the quasi-periodic patterns (QPPs), and co-activation (CAPs) that were shown to be sensitive markers neurodegenerative diseases in rodent models humans. We investigated effect early suppression mutant huntingtin (mHtt) expression LacQ140 mouse model Huntington’s disease (HD) on QPP CAP alterations at manifest state. In both QPPs CAPs, observed genotypic changes local activity reduced mHtt suppressed...
Motivation: Robust translational imaging biomarkers are needed to facilitate the development of disease-modifying treatments for Huntington’s disease (HD), a rare inherited neurodegenerative disease. Goal(s): To determine use structural atrophy determined with MRI as robust biomarker testing therapeutics in mouse models prior people HD. Approach: In this work, we used semi-automatic delineations and tensor-based morphometry (TBM) 3D high-resolution anatomical MR images assess...
Huntington’s disease (HD) is a neurodegenerative disorder that affects motor and cognitive abilities. In this study, we present the outcome of longitudinal multi-shell DWI investigation zQ175 HD mouse model using diffusion tensor, kurtosis, fixel-based analysis. This study reveals microstructural deficits at an early stage mainly affect tensor in corpus callosum kurtosis caudate putamen grey matter, while fiber cross-section reduced major bundles. At late stage, many white matter...