A5092521474- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Marine animal studies overview
- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
University of Antwerp
2023-2025
Huntington's disease (HD) is a progressive neurodegenerative affecting motor and cognitive abilities. Multiple studies have found white matter anomalies in HD-affected humans animal models of HD. The identification sensitive white-matter-based biomarkers HD will be important understanding mechanisms testing the efficacy therapeutic interventions. Here we investigated progression deficits knock-in zQ175DN heterozygous (HET) mouse model at 3, 6 11 months age (M), reflecting different states...
Huntington’s disease (HD) is a neurodegenerative disorder for which no cure available. There an urgent need to find early biomarkers are sensitive enough determine and follow up the efficacy of novel therapies. In this study, we present outcome treatment study in LacQ140 HD mouse model using diffusion tensor/kurtosis imaging (DTI/DKI) fixel-based analysis (FBA). We observed that early, moderate lowering mutant Huntingtin (mHtt) rescues structural alterations measured with MRI olfactory bulb...
The present study aims to investigate whether begging calls elicit specific auditory responses in non-parenting birds, these are influenced by the hormonal status of bird, and they reflect biparental care for offspring European starling ( Sturnus vulgaris ). An fMRI experiment was conducted expose male female starlings recordings conspecific nestling during both artificially induced breeding non-breeding seasons. This response compared with their reaction individual warbling song motifs...
Motivation: Robust translational imaging biomarkers are needed to facilitate the development of disease-modifying treatments for Huntington’s disease (HD), a rare inherited neurodegenerative disease. Goal(s): To determine use structural atrophy determined with MRI as robust biomarker testing therapeutics in mouse models prior people HD. Approach: In this work, we used semi-automatic delineations and tensor-based morphometry (TBM) 3D high-resolution anatomical MR images assess...
Abstract Avian innate nestling begging calls are similar to human infant cries in the behavioral response they elicit. However, it remains unknown whether auditory processing of changes seasonal songbirds from non-breeding breeding season when hormonal neuromodulation forebrain occurs. An fMRI experiment was set up expose male and female European starlings ( Sturnus vulgaris ) recordings conspecific season. This compared with their warble motifs artificial pure tones, both proven seasonally...
Huntington’s disease (HD) is a neurodegenerative disorder that affects motor and cognitive abilities. In this study, we present the outcome of longitudinal multi-shell DWI investigation zQ175 HD mouse model using diffusion tensor, kurtosis, fixel-based analysis. This study reveals microstructural deficits at an early stage mainly affect tensor in corpus callosum kurtosis caudate putamen grey matter, while fiber cross-section reduced major bundles. At late stage, many white matter...