A5053701987- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Animal Vocal Communication and Behavior
- Genetic Neurodegenerative Diseases
- Neural dynamics and brain function
- Marine animal studies overview
- Neuroscience and Neuropharmacology Research
- Animal Behavior and Reproduction
- Atomic and Subatomic Physics Research
- Medical Image Segmentation Techniques
- Avian ecology and behavior
- Sparse and Compressive Sensing Techniques
- Image and Signal Denoising Methods
- Alzheimer's disease research and treatments
- Physiological and biochemical adaptations
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Photoreceptor and optogenetics research
- NMR spectroscopy and applications
- Neonatal and fetal brain pathology
- Fish Ecology and Management Studies
- Bat Biology and Ecology Studies
University of Antwerp
2015-2025
At present, resting state functional MRI (rsfMRI) is increasingly used in human neuropathological research. The present study aims at implementing rsfMRI mice, a species that holds the widest variety of neurological disease models. Moreover, by acquiring data with comparable protocol for anesthesia, scanning and analysis, both rats mice we were able to compare findings obtained species. outcome different depends strongly on applied number components Independent Component Analysis (ICA). most...
Huntington's disease is an autosomal, dominantly inherited neurodegenerative caused by expansion of the CAG repeats in exon 1 huntingtin gene. Neuronal degeneration and dysfunction that precedes regional atrophy result impairment striatal cortical circuits affect brain's large-scale network functionality. However, evolution these disease-driven, connectivity alterations still poorly understood. Here we used resting-state fMRI to investigate functional changes a mouse model several relevant...
In this paper, we propose a method to denoise magnitude magnetic resonance (MR) images, which are Rician distributed. Conventionally, maximum likelihood methods incorporate the Rice distribution estimate true, underlying signal from local neighborhood within is assumed be constant. However, if assumption not met, such filtering will lead blurred edges and loss of fine structures. As solution problem, put forward concept restricted neighborhoods where true intensity for each noisy pixel...
Introduction Dietary interventions such as caloric restriction (CR) exert positive effects on brain health. Unfortunately, poor compliance hinders the success of this approach. A proposed alternative is resveratrol (Rsv), a CR-mimetic known to promote Direct comparison between Rsv and CR health lacking, with limited knowledge their sex-specific effects. Therefore, we aimed compare unravel impact these dietary spontaneous activity. Methods Here, used resting-state fMRI investigate functional...
To determine the reproducibility of quantitative susceptibility mapping at multiple sites on clinical and preclinical scanners (1.5 T, 3 7 9.4 T) from different vendors (Siemens, GE, Philips, Bruker) for standardization multicenter studies.Seven phantoms distributed core site, each containing 5 compartments with gadolinium solutions fixed concentrations between 0.625 mM 10 mM. Multi-echo gradient echo scans were performed 1.5 T 12 scanners. DICOM images processed into maps using Laplacian...
Abstract Background Imbalanced synaptic transmission appears to be an early driver in Alzheimer’s disease (AD) leading brain network alterations. Early detection of altered and insight into mechanisms causing alterations would valuable treatment strategies. This study aimed investigate how whole-brain networks are influenced at pre- early-plague stages AD if these manifestations associated with concomitant cellular deficits. Methods To this end, we used established rat model (TgF344-AD)...
Huntington's disease (HD) is a progressive neurodegenerative affecting motor and cognitive abilities. Multiple studies have found white matter anomalies in HD-affected humans animal models of HD. The identification sensitive white-matter-based biomarkers HD will be important understanding mechanisms testing the efficacy therapeutic interventions. Here we investigated progression deficits knock-in zQ175DN heterozygous (HET) mouse model at 3, 6 11 months age (M), reflecting different states...
Although effective in reducing relapse rate and delaying progression, current therapies for multiple sclerosis (MS) do not completely halt disease progression. T cell autoimmunity to myelin antigens is considered one of the main mechanisms driving MS. It characterized by autoreactivity disease-initiating antigen epitope(s), followed a cascade epitope spreading, which are both strongly patient-dependent. Targeting variety MS-associated antigen-presenting tolerogenic dendritic cells (tolDC)...
Abstract Background Huntington’s disease (HD) is marked by a CAG-repeat expansion in the huntingtin gene that causes neuronal dysfunction and loss, affecting mainly striatum cortex. Alterations neurovascular coupling system have been shown to lead dysregulated energy supply brain regions several neurological diseases, including HD, which could potentially trigger process of neurodegeneration. In particular, it has observed cross-sectional human HD studies vascular alterations are associated...
In quantitative MR T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> mapping, the spin-lattice relaxation time of tissues is estimated from a series -weighted images. As estimation voxel-wise procedure, correct spatial alignment images crucial. Conventionally, are first registered based on general-purpose registration metric, after which map estimated. However, as demonstrated in this paper, such two-step approach leads to bias final...
How do intrinsic brain dynamics interact with processing of external sensory stimuli? We sought new insights using functional magnetic resonance imaging to track spatiotemporal activity patterns at the whole level in lightly anesthetized mice, during both resting conditions and visual stimulation trials. Our results provide evidence that quasiperiodic (QPPs) are most prominent component mouse dynamics. These QPPs captured temporal alignment anticorrelation between default mode (DMN)-...
Recently, fMRI was introduced in a well-documented animal model for vocal learning, the songbird. Using and conspecific signals mixed with different levels of broadband noise, we now demonstrate auditory-induced activation representing discriminatory properties auditory forebrain regions anesthetized male zebra finches ( Taeniopygia guttata). Earlier behavioral tests showed comparable calling responses to original song stimulus heard outside inside magnet. A significant response elicited by...