Purpose To assess the reproducibility of brain quantitative susceptibility mapping (QSM) in healthy subjects and patients with multiple sclerosis (MS) on 1.5 3T scanners from two vendors. Materials Methods Ten volunteers 10 were scanned twice a scanner one vendor. The also 1.5T same vendor second Similar imaging parameters used for all scans. QSM images reconstructed using recently developed nonlinear morphology‐enabled dipole inversion (MEDI) algorithm L1 regularization. Region‐of‐interest...

Abstract Purpose To investigate the safety and value of hyperpolarized (HP) MRI [1‐ 13 C]pyruvate in healthy volunteers using deuterium oxide (D 2 O) as a solvent. Methods Healthy ( n = 5), were injected with HP dissolved D O imaged metabolite‐specific 3D dual‐echo dynamic EPI sequence at 3T one site (Site 1). Volunteers monitored following procedure to assess safety. Image characteristics, including SNR, compared data acquired separate cohort water solvent 5) another 2). The apparent...

To demonstrate the phase and quantitative susceptibility mapping (QSM) patterns created by solid shell spatial distributions of magnetic in multiple sclerosis (MS) lesions.Numerical simulations experimental phantoms solid- shell-shaped sources were used to generate magnitude, phase, QSM images. Imaging 20 consecutive MS patients was also reviewed for this Institutional Review Board (IRB)-approved MRI study identify appearance lesions on images.Solid correctly reconstructed images, while...

Purpose To develop and measure the reproducibility of 4-min whole brain myelin water fraction (MWF) mapping using fast acquisition with spiral trajectory T2prep (FAST-T2) sequence at 3T. Methods Experiments were performed on phantoms, 13 volunteers, 16 patients multiple sclerosis. MWF maps extracted a spatially constrained non-linear algorithm. The proposed adiabatic modified BIR-4 (mBIR-4) was compared conventional composite (COMP). effect reducing number echo times (TEs) from 15 to 6...

Background The pathological processes in the first weeks of multiple sclerosis (MS) lesion formation include myelin digestion that breaks chemical bonds lipid layers. This can increase magnetic susceptibility, which is a potentially useful biomarker MS patient management, but not yet investigated. Purpose To understand and quantify effects on quantitative susceptibility mapping (QSM) lesions. Study Type Histological QSM analyses vitro models breakdown vivo. Population/Specimens Acutely...

To determine the reproducibility of quantitative susceptibility mapping at multiple sites on clinical and preclinical scanners (1.5 T, 3 7 9.4 T) from different vendors (Siemens, GE, Philips, Bruker) for standardization multicenter studies.Seven phantoms distributed core site, each containing 5 compartments with gadolinium solutions fixed concentrations between 0.625 mM 10 mM. Multi-echo gradient echo scans were performed 1.5 T 12 scanners. DICOM images processed into maps using Laplacian...

Background Accurate measurement of the liver iron concentration (LIC) is needed to guide iron‐chelating therapy for patients with transfusional overload. In this work, we investigate feasibility automated quantitative susceptibility mapping (QSM) measure LIC. Purpose To develop a rapid, robust, and QSM clinical practice. Study Type Prospective. Population 13 healthy subjects 22 patients. Field Strength/Sequences 1.5 T 3 T/3D multiecho gradient‐recalled echo (GRE) sequence. Assessment Data...

Purpose To demonstrate the feasibility of in vivo quantitative susceptibility mapping (QSM) cardiac MRI and to show that mixed‐venous oxygen saturation (SvO 2 ) can be measured non‐invasively using QSM. Methods Electrocardiographic‐gated multi‐echo 2D gradient echo data were collected at 1.5 T from 14 healthy volunteers during successive breath‐holds. Phase wraps fat chemical shift removed a graph‐cut‐based phase analysis IDEAL an iterative approach. The large range air lungs blood heart was...

Abstract The use of magnetic fluid hyperthermia (MFH) for cancer therapy has shown promise but lacks suitable methods quantifying exogenous irons such as superparamagnetic iron oxide (SPIO) nanoparticles a source heat generation under an alternating field (AMF). Application quantitative susceptibility mapping (QSM) technique to prediction SPIO in preclinical models been challenging due large variation values, chemical shift from tissue fat, and noisier data arising the higher resolution...

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> The sliding motion of the liver during respiration violates homogeneous smoothness assumption in conventional nonrigid image registration and commonly results compromised accuracy. This paper presents a novel approach, with three-dimensional (3D) active contour segmentation (RAMS), to improve accuracy discontinuity-aware regularization....

Differential blood oxygenation between left (LV) and right ventricles (RV; ΔSaO

Abstract Hepatocellular carcinoma (HCC) is one of the leading causes cancer‐related deaths. Imaging plays a crucial role in early detection HCC, although current methods are limited their ability to characterize liver lesions. Most recently, deuterium metabolic imaging (DMI) has been demonstrated as powerful technique for metabolism vivo. Here, we assess flux [6,6′‐ 2 H ] fructose cell cultures and subcutaneous mouse models at 9.4 T. We compare these rates with most widely used DMI probe,...

To investigate the computational aspects of prior term in quantitative susceptibility mapping (QSM) by (i) comparing Gauss-Newton conjugate gradient (GNCG) algorithm that uses numerical conditioning (ie, modifies term) with a primal-dual (PD) formulation avoids this, and (ii) carrying out comparison between central forward difference scheme for discretization term.A spatially continuous regularized QSM inversion problem its PD were derived. The Chambolle-Pock was implemented convergence...

Purpose To investigate an anisotropic structural prior in morphology enabled dipole inversion (MEDI) for improving accuracy quantitative susceptibility mapping (QSM). Theory and Methods Anisotropic weighting (AW) was devised implemented to incorporate orientation information into the edge agreement MEDI method. AW performance compared with isotropic by testing validating on vivo brain multiple MRI data using COSMOS (33) component of tensor as reference. Results Suppressing streaking...

Purpose To generate dynamic, volumetric maps of hyperpolarized [1‐ 13 C]pyruvate and its metabolic products in vivo. Methods Maps chemical species were generated with iterative least squares (IDEAL) reconstruction from multiecho echo‐planar imaging (EPI) phantoms thermally polarized C‐labeled chemicals mice injected on a preclinical 3T scanner. The quality the IDEAL decomposition single‐shot multishot phantom images was evaluated using quantitative results simple pulse‐and‐acquire sequence...

Abnormal metabolism is a hallmark of cancer cells. Accumulating evidence suggests that metabolic changes are likely to occur before other cellular responses in cells upon drug treatment. Therefore, the activity or flux could be potent biomarker for detection and treatment monitoring. Magnetic resonance (MR)-based sensing technologies have been developed with hyperpolarized molecules real-time analysis, but they still suffer from low sensitivity throughput. To address this limitation, we an...

Abstract BACKGROUND Noninvasive biomarkers for treatment response in glioblastoma are needed to improve patient outcomes. Our understanding of redox biology resistance is rapidly evolving, and interrogation tumor metabolism represents an ideal opportunity meet this need. In study, the utility co-hyperpolarized [1-13C]pyruvate [1-13C]dehydroascorbate (HP PA/DHA) simultaneously evaluate brain oxidative stress orthotopically implanted mice investigated. METHODS To characterize HP PA/DHA, were...

Motivation: Whole-abdomen imaging with hyperpolarized [1-13C]pyruvate holds promise to diagnose metabolic diseases. D2O solvation could extend the 13C T1 lifetime, resulting in enhanced image SNR. Goal(s): Establish safety and feasibility of utilizing administer whole-abdomen imaging, present first application MRI a PDAC patient. Approach: We quantified characteristics organs healthy diseased subjects. Results: The use is safe feasible. It has no significant impact on organ metabolism...

There is a clear need for an accurate and practical dosimeter that able to verify 3-D dose distributions from complex radiation treatments. The purpose of this study evaluate the dosimetric performance PRESAGE radiochromic plastic in conjunction with cone-beam optical CT scanner, VistaTM, dosimetry. scanner presented can perform readout less than 30 min, which makes same day verification treatment possible. For accuracy, complete procedures were performed, including response calibration 12...