Keloids (KD) and hypertrophic scars (HTS), which are quite raised pigmented have increased vascularization cellularity, formed due to the impaired healing process of cutaneous injuries in some individuals having family history genetic factors. These decrease quality life (QOL) patients greatly, pain, itching, contracture, cosmetic problems, so on, depending on location scars. Treatment/prevention that will satisfy patients’ QOL is still under development. In this article, we review...

Effects of cytochrome P-450 3A- and P-glycoprotein (P-gp)-related compounds, erythromycin, midazolam, ketoconazole, verapamil, quinidine, on transport rhodamine 123 (Rho-123), a P-gp substrate, were studied in rat intestine Caco-2 cells. Ileum was mainly used studies because this segment showed greater P-gp-mediated Rho-123 transport. In an vitro everted ileum, all the compounds examined significantly inhibited from serosal to mucosal surfaces across intestine, with different inhibitory...

Although active targeting of anticancer drugs using magnetically responsive carriers is a very attractive treatment approach for solid tumors, successful results are limited. In particular, the therapeutic utility intravenously administered has to date not been clearly established. The present study investigates magnetic liposomes designed act as drug carriers, which can be effectively delivered tumors via intravenous administration. Magnetic with incorporated adriamycin (magnetic ADR...

The development of an active drug delivery system is attractive approach to increase the targetability anticancer agents. In present study, we examined efficiency systemic chemotherapy with small magnetic liposomes containing doxorubicin (magnetic DOX liposomes) and externally applied electromagnetic force in osteosarcoma-bearing hamsters. Syrian male hamsters inoculated osteosarcoma, OS515, limb were studied 7 days after inoculation. this was evaluated by measuring tissue distribution...

The role of megalin in tissue distribution aminoglycosides was examined normal rats and maleate-treated that shed from the renal brush-border membrane. In rats, amikacin administered intravenously accumulated most abundantly cortex, followed by medulla. No detected other tissues. Tissue distributions were well correlated with levels each tissue. Bolus administration gentamicin increased urinary excretion ligands (vitamin D binding protein calcium), suggesting competition between these...

Small-sized magnetic liposomes with incorporated recombinant human bone morphogenetic protein-2 (rhBMP-2) were prepared, and the efficiency for formation after topical injection was evaluated in a rat bone-defect model. A critical-sized segmental defect created mid-part of femoral shaft, permanent magnet attached. Topical onto defects performed different liposomal preparations (nonmagnetic liposomes) using treatment modalities (different doses timing rhBMP-2). Weekly evaluations made...

In-vitro permeability to salicylic acid of human, rodent, and shed snake skin has been examined for the purpose selecting model membranes human corresponding different anatomic sites, since a marked regional variation is suggested among sites. The greatest was observed in scrotum, that sole negligible. cheek, neck, inguinal seemed more permeable than breast, back, thigh, lower leg, or foot skin. Shed hairless rat were found show similar breast thigh Wistar nude mouse showed

The rectal absorption of sodium ampicillin in the presence various bile salts, such as dehydrocholate, dihydroxycholate, trihydroxycholate, and their glycine taurine conjugates, was investigated using situ rat loop method. A marked but variable absorptionpromoting effect observed with whereas trihydroxy triketo salts did not enhance ampicillin. These results suggest that promoting efficacy for depends upon chemical structures and/or physicochemical properties. Solubilizing activity,...

In irinotecan (CPT-11)-based chemotherapy, neutropenia and diarrhea are often induced. the present study, clinical significance of concentration ratios 7-ethyl‑10-hydroxycamptothecin (SN-38) glucuronide (SN-38G) SN-38 in plasma predicting CPT-11‑induced was examined. A total 17 patients with colorectal cancer wild-type UDP-glucuronosyltransferase (UGT)1A1 gene were enrolled treated CPT-11 as part FOLFIRI regimen [CPT-11 fluorouracil (5-FU)]. Blood taken exactly 15 min following a 2-h...

The feasibility of iontophoretic transdermal delivery tranilast (N-(3,4-dimethoxycinnamoyl) anthranilic acid) for the treatment keloid and hypertrophic scars was evaluated in hairless rats humans. A drug electrode containing 1.5 ml (8 mg/ml ethanol/water (8/2, v/v) mixture) placed on dorsal skin surface anaesthetised or affected parts patients, connected to negative pole; an electric current (0.5-4 mA rats, 2 people) pulsed through at one minute intervals. Tranilast effectively delivered...

Abstract We evaluated the efficacy of a magnetic liposomal delivery system transforming growth factor (TGF)‐β 1 in treatment articular cartilage defects rabbit model. Articular were created patellar groove rabbits, and permanent magnet or nonmagnetic alloy was implanted defect site. Magnetic drugs, prepared by conventional film method sonication, injected into site week after surgery. First, using model compound fluorescence‐labeled dextran 40,000 (FD‐40). Then, therapeutic efficiency TGF‐β...

Mizoribine is administered orally and excreted into urine without being metabolized. Many research groups have reported a linear relationship between the dose peak serum concentration, AUC, AUC cumulative urinary excretion of mizoribine. In contrast, significant interindividual variability, with small intraindividual in oral bioavailability mizoribine also reported. The variability mostly considered to be due polymophisms transporter genes. Methotrexate (MTX) and/or by parenteral routes,...