A5056695439- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Alcohol Consumption and Health Effects
- Biochemical effects in animals
- Cholesterol and Lipid Metabolism
- Health and Lifestyle Studies
- Obesity, Physical Activity, Diet
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Pesticide Exposure and Toxicity
- Problem and Project Based Learning
- Cholinesterase and Neurodegenerative Diseases
- Fatty Acid Research and Health
- Sleep and related disorders
- Retinoids in leukemia and cellular processes
- Mental Health Research Topics
- Circadian rhythm and melatonin
- Substance Abuse Treatment and Outcomes
University of Almería
2008-2025
Universidad Autónoma de Chile
2014-2019
Universidad de Oviedo
2017-2019
Centro de Estudios Científicos
2017
Università di Camerino
2013-2014
University of North Carolina at Chapel Hill
2010-2011
Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol, are highly sensitive to stress and stress-induced alcohol seeking. Genetic analysis showed that over-expression of the corticotropin-releasing factor (CRF) system msP is correlated with presence two single nucleotide polymorphisms (SNPs) occurring in promoter region (position -1836 -2097) CRF1 receptor (CRF1-R) gene. Here we examined whether these point mutations were associated preference, drinking We...
The melanocortin (MC) system is composed of peptides that are cleaved from the polypeptide precursor proopiomelanocortin (POMC). Recent evidence shows chronic exposure to ethanol significantly blunts central MC peptide immunoreactivity and receptor (MCR) agonists protect against high intake characteristic C57BL/6J mice. Here, we assessed role MC-4 (MC4R) in voluntary modulating effects nonselective MCR agonist melanotan-II (MTII) on consumption.To assess MC4R, MC4R knockout (Mc4r(-/-) )...
The melanocortin (MC) system is composed of peptides that are cleaved from the polypeptide precursor, pro-opiomelanocortin (POMC). Previous research has shown MC receptor (MCR) agonists reduce, and MCR antagonists increase, ethanol consumption in rats mice. Consistently, genetic deletion endogenous antagonist, agouti-related protein (AgRP), causes reductions ethanol-reinforced lever pressing binge-like drinking C57BL/6J Ethanol also direct effects on central system, as chronic exposure to an...
Background The nonselective opioid receptor antagonist, naltrexone (NAL), reduces alcohol (ethanol [EtOH]) consumption in animals and humans is an approved medication for treating abuse disorders. Proopiomelanocortin (POMC)-derived melanocortin (MC) peptides are produced the same neurons brain, recent preclinical evidence shows that MC (MCR) agonists reduce excessive EtOH drinking animal models. Interestingly, there a growing body of literature revealing interactions between systems...
ABSTRACT Neuropeptide Y (NPY) and protein kinase A (PKA) have been implicated in neurobiological responses to ethanol. We previously reported that mutant mice lacking normal production of the RIIβ subunit PKA (RIIβ−/− mice) show enhanced sensitivity locomotor stimulant effects ethanol increased behavioral sensitization relative littermate wild‐type RIIβ+/+ mice. now report RIIβ−/− also NPY immunoreactivity nucleus accumbens (NAc) core ventral striatum These observations suggest elevated...
Alcohol dependence causes physical, social, and moral harms currently represents an important public health concern. According to the World Health Organization (WHO), alcoholism is third leading cause of death worldwide, after tobacco consumption hypertension. Recent epidemiologic studies have shown a growing trend in alcohol abuse among adolescents, characterized by large doses over short time period. Since brain development ongoing process during adolescence, short- long-term damage...
ABSTRACT Background Binge alcohol drinking is a dangerous pattern of consumption that can contribute to the development more severe use disorders (AUDs). Importantly, rate and severity AUDs has historically differed between men women, suggesting there may be sex differences in central mechanisms modulate (ethanol) consumption. Corticotropin releasing factor (CRF) centrally expressed neuropeptide been implicated modulation binge-like ethanol intake, emerging data highlight CRF systems....
The melanocortin (MC) system regulates feeding and ethanol consumption. Recent evidence shows that 4 receptor (MC4-R) stimulation within the nucleus accumbens (NAc) elicits anorectic responses reduces consumption palatability in adult rats. Ethanol exposure during adolescence causes long-lasting changes neural pathways critically involved neurobehavioral to ethanol. In this regard, binge-like basal alpha-melanocyte-stimulating hormone (α-MSH) alters levels of agouti-related peptide (AgRP)...
Alcohol use in adolescents is often characterized by binge-like ethanol consumption pattern, which associated with long-term health consequences and even important harms to his developing brain. Among this, exposure induces long-lasting alterations anxiety-related neurobiological systems such as corticotropin releasing factor (CRF) or melanocortin system (MC). Recently, it has been demonstrated that adult rats exposed adolescent intermittent (AIE) exhibited anxiogenic-like behavior. Given...
RESUMEN: El consumo problemático de alcohol en jóvenes se ha asociado con graves consecuencias sociales, salud y económicas, generando enormes costos para los sistemas la salud. Diversos estudios muestran que cuanto más temprano comienza el uso sustancias, mayor es probabilidad desarrollar un trastorno sustancias adultez. Sin embargo, esta relación encuentra mediada por diversos factores riesgo tanto contextuales (p.ej., historia alcoholismo familiar) como individuales descontrol impulsos)....