A5101677036- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Genetics and Neurodevelopmental Disorders
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Nuclear Receptors and Signaling
- Biochemical effects in animals
- Andrographolide Research and Applications
- Amino Acid Enzymes and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Signaling Pathways in Disease
- Apelin-related biomedical research
- Endoplasmic Reticulum Stress and Disease
- Genetic Neurodegenerative Diseases
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Cholinesterase and Neurodegenerative Diseases
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Alcoholism and Thiamine Deficiency
San Sebastián University
2018-2025
Fundación Ciencia and Vida
2023-2025
Universidad de Magallanes
2020
Pontificia Universidad Católica de Chile
2011-2020
Universidad Autónoma de Chile
2016-2020
Fundación Chile
2013-2014
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by loss of memory and cognitive abilities, the appearance amyloid plaques composed amyloid-β peptide (Aβ) neurofibrillary tangles formed tau protein. It has been suggested that exercise might ameliorate disease; here, we evaluated effect voluntary running on several aspects AD including deposition, phosphorylation, inflammatory reaction, neurogenesis spatial in double transgenic APPswe/PS1ΔE9 mouse model AD. We report...
We have synthesized a family of rhein-huprine hybrids to hit several key targets for Alzheimer's disease. Biological screening performed in vitro and Escherichia coli cells has shown that these exhibit potent inhibitory activities against human acetylcholinesterase, butyrylcholinesterase, BACE-1, dual Aβ42 tau antiaggregating activity, brain permeability. Ex vivo studies with the leads (+)- (-)-7e slices C57bl6 mice revealed they efficiently protect Aβ-induced synaptic dysfunction,...
Alzheimer's disease (AD) is an age-related neurodegenerative disorder associated with progressive memory loss, severe dementia, and hallmark neuropathological markers, such as deposition of amyloid-β (Aβ) peptides in senile plaques accumulation hyperphosphorylated tau proteins neurofibrillary tangles. Recent evidence obtained from transgenic mouse models suggests that soluble, nonfibrillar Aβ oligomers may induce synaptic failure early AD. Despite their undoubted value, these rely on genetic...
Alzheimer’s disease (AD) is a neurodegenerative disorder in which the amyloid-β (Aβ) oligomers are key factor synaptic impairment and spatial memory decline associated with neuronal dysfunction. This includes failure loss of proteins that contribute to AD progression. Interestingly, use natural compounds an emergent conceptual strategy search for drugs therapeutic potentials treating disorders. In present study, we report andrographolide (ANDRO), labdane diterpene extracted from Andrographis...
Aging is a process characterized by cognitive impairment and mitochondrial dysfunction. In neurons, these organelles are classified as synaptic non-synaptic mitochondria depending on their localization. Interestingly, from the cerebral cortex accumulate more damage sensitive to swelling than mitochondria. The hippocampus fundamental for learning memory, processes with high energy demand. However, it unknown if functional differences found in hippocampal mitochondria; whether this could...
Abstract Brain aging is a natural process characterized by cognitive decline and memory loss. This impairment related to mitochondrial dysfunction has recently been linked the accumulation of abnormal proteins in hippocampus. Age-related could be induced modified forms tau. Here, we demonstrated that phosphorylated tau at Ser 396/404 sites, epitope known as PHF-1, increased hippocampus aged mice same time oxidative damage are observed. Most importantly, showed PHF-1 located hippocampal...
L-methionine, the principal sulfur-containing amino acid in proteins, plays critical roles cell physiology as an antioxidant and breakdown of fats heavy metals. Previous studies suggesting use L-methionine a treatment for depression other diseases indicate that it might also improve memory propose role brain function. However, some evidence indicates excess methionine can be harmful increase risk developing Type-2 diabetes, heart diseases, certain types cancer, alterations such...
Tau is a key protein for microtubule stability; however, post-translationally modified tau contributes to neurodegenerative diseases by forming aggregates in the neurons. Previous reports from our group and others have shown that pathological forms of are toxic impair mitochondrial function, whereas deletion neuroprotective. However, effects ablation on brain structure function young mice not been fully elucidated. Therefore, aim this study was investigate implications cognitive abilities...
Wnt/β-catenin signalling is an important pathway that regulates multiple biological processes, including cell adhesion and determination of fate during animal development; in the adult nervous system it structure function synapses. Wnt-signalling dysfunction associated with several neurodegenerative diseases such as schizophrenia Alzheimer's disease. The use natural compounds interesting strategy search for drugs therapeutic potential to activate this pathway. In present study, we report...
Abstract Alzheimer's disease ( AD ) is a neurodegenerative pathology characterized by aggregates of amyloid‐β (Aβ) and phosphorylated tau protein, synaptic dysfunction, spatial memory impairment. The Wnt signaling pathway has several key functions in the adult brain been associated with , mainly as neuroprotective factor against Aβ toxicity phosphorylation. However, dysfunction Wnt/β‐catenin might also play role onset development disease. J20 APP swInd transgenic (Tg) mouse model was treated...
Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder and frequent cause of dementia in aged population. According to amyloid hypothesis, amyloid‐β (Aβ) peptide plays a key role pathogenesis AD. Aβ generated from amyloidogenic processing precursor protein can aggregate form oligomers, which have been described as major synaptotoxic agent neurons. Dysfunction Wnt signaling has linked increased formation; however, several other studies argued against this possibility....
Andrographolide (ANDRO) is a labdane diterpenoid component of Andrographis paniculata widely used for its anti-inflammatory properties. We have recently determined that ANDRO competitive inhibitor glycogen synthase kinase-3 β (GSK-3 ), key enzyme the Wnt/ -catenin signaling cascade. Since this pathway regulates neurogenesis in adult hippocampus, we evaluated whether stimulates process. Treatment with increased neural progenitor cell proliferation and number immature neurons hippocampus 2-...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive abilities, amyloid-β peptide (Aβ) accumulation and synaptic alterations. Previous studies indicated that hyperforin, component the St John's Wort, prevents Aβ neurotoxicity some behavioral impairments in rat model AD. In this study we examined ability tetrahydrohyperforin (IDN5607), stable hyperforin derivative, to prevent deficit impairment an vivo double transgenic...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive abilities, accumulation the amyloid-β peptide (Aβ), increase oxidative stress, and synaptic alterations. The scavenging reacti
New studies show that the retina also undergoes pathological changes during development of Alzheimer's disease (AD). While transgenic mouse models used in these previous have offered insight into this phenomenon, they do not model human sporadic AD, which is most common form. Recently, Octodon degus has been established as a AD. Degus display age-related cognitive impairment associated with Aβ aggregates and phosphorylated tau brain. Our aim for study was to examine expression AD-related...