A5055826036- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Diabetes Management and Research
- Pancreatic function and diabetes
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes and associated disorders
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Metabolism and Genetic Disorders
- Chronic Kidney Disease and Diabetes
- Immune Cell Function and Interaction
- Alcoholism and Thiamine Deficiency
- Neurological Complications and Syndromes
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Biochemical Acid Research Studies
- Stress Responses and Cortisol
- Calcium signaling and nucleotide metabolism
- COVID-19 Impact on Reproduction
- Laser Applications in Dentistry and Medicine
- Tryptophan and brain disorders
- Mesenchymal stem cell research
San Sebastián University
2016-2024
Fundación Ciencia and Vida
2024
Austral University of Chile
2019-2024
Universidad Mayor
2022
Universidad Autónoma de Chile
2015-2021
University of Chile
2014-2020
Weatherford College
2020
Universidad de Santiago de Chile
2018
Universidad Bernardo O'Higgins
2016
Aging is a process characterized by cognitive impairment and mitochondrial dysfunction. In neurons, these organelles are classified as synaptic non-synaptic mitochondria depending on their localization. Interestingly, from the cerebral cortex accumulate more damage sensitive to swelling than mitochondria. The hippocampus fundamental for learning memory, processes with high energy demand. However, it unknown if functional differences found in hippocampal mitochondria; whether this could...
Abstract Brain aging is a natural process characterized by cognitive decline and memory loss. This impairment related to mitochondrial dysfunction has recently been linked the accumulation of abnormal proteins in hippocampus. Age-related could be induced modified forms tau. Here, we demonstrated that phosphorylated tau at Ser 396/404 sites, epitope known as PHF-1, increased hippocampus aged mice same time oxidative damage are observed. Most importantly, showed PHF-1 located hippocampal...
Tau is a key protein for microtubule stability; however, post-translationally modified tau contributes to neurodegenerative diseases by forming aggregates in the neurons. Previous reports from our group and others have shown that pathological forms of are toxic impair mitochondrial function, whereas deletion neuroprotective. However, effects ablation on brain structure function young mice not been fully elucidated. Therefore, aim this study was investigate implications cognitive abilities...
Diabetic nephropathy (DN) is considered the main cause of kidney disease in which myofibroblasts lead to renal fibrosis. Macrophages were recently identified as major source a process known macrophage–myofibroblast transition (MMT). Adenosine levels increase during DN and vivo administration MRS1754, an antagonist A2B adenosine receptor (A2BAR), attenuated glomerular fibrosis (glomerulosclerosis). We aimed investigate association between A2BAR MMT glomerulosclerosis DN. Kidneys/glomeruli...
High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding HFD increases the concentration of saturated fatty acid palmitic (PA) in hypothalamus. We previously showed that, hypothalamic neuronal cells, exposure to PA inhibits autophagic flux, which whole process from synthesis autophagosomes, up their lysosomal fusion and degradation. However, mechanism by impairs autophagy neurons remains unknown. Here, we show that PA-mediated reduction flux not caused...
Aging is an irreversible process and the primary risk factor for development of neurodegenerative diseases, such as Alzheimer’s disease (AD). Mitochondrial impairment a that generates oxidative damage ATP deficit; both factors are important in memory decline showed during normal aging AD. Tau microtubule-associated protein, with strong influence on morphology physiology neurons. In AD, tau protein undergoes post-translational modifications, which could play relevant role onset progression...
In this study, we investigated the inter-organelle communication between Golgi apparatus (GA) and mitochondria. Previous observations suggest that GA-derived vesicles containing phosphatidylinositol 4-phosphate (PI(4)P) play a role in mitochondrial fission, colocalizing with DRP1, key protein process. However, functions of these potentially associated proteins remain unknown. GOLPH3, PI(4)P-interacting GA protein, is elevated various types solid tumors, including breast cancer, yet its...
Aging is a physiological process that generates progressive decline in many cellular functions. There are theories of aging, and one great importance recent years the mitochondrial theory which dysfunction occurs at advanced age could be responsible for aged phenotype. In this context, there diverse information about different models organs. Specifically, brain, studies have shown mainly cortex; however, until now, no study has all defects hippocampal mitochondria female C57BL/6J mice. We...
Induction of the adenosine receptor A
Diabetic nephropathy (DN) is the main cause of end-stage renal disease, which remains incurable. The progression DN associated with progressive and irreversible fibrosis also high levels adenosine. Our aim was to evaluate effects ADORA3 antagonism on injury in streptozotocin-induced diabetic rats. An antagonist that administered rats greatly inhibited inflammatory interleukins IL-1β IL-18, meanwhile when adenosine deaminase administered, there a non-selective attenuation mediators IL-1β,...
Many species of Drosophila form conspecific pupa aggregations across the breeding sites. These could result from species-specific larval odor recognition. To test this hypothesis we used odors D. melanogaster and pavani, two that coexist in nature. When stimulated by those odors, wild type vestigial (vg) third-instar larvae pupated on but individuals deficient expression co-receptor Orco randomly substrate, indicating species, olfaction plays a role pupation site selection. Larvae are unable...
Alzheimer’s Disease (AD) is the primary cause of dementia among elderly population. Elevated plasma levels homocysteine (HCy), an amino acid derived from methionine metabolism, are considered a risk factor and biomarker AD other types dementia. An increase in HCy mostly consequence high and/or low vitamin B intake diet. Here, we studied effects physiological pathophysiological concentrations on oxidative stress, synaptic protein levels, activity mice hippocampal slices. We also vitro...
Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in antitumor defense reactions. NK cell effector functions critically dependent on cytokines and metabolic activity. Among various modulating function, interleukin-2 (IL-2) can induce more potent cytotoxic activity defined as lymphokine activated killer (LAK). Our aim was to determine if IL-2 induces changes at the mitochondrial level support bioenergetic demand for performing this enhanced...
Some chemoattractants and leukocytes such as M1 M2 macrophages are known to be involved in the development of glomerulosclerosis during diabetic nephropathy (DN). In course diabetes, an altered defective cellular metabolism leads increase adenosine levels, thus changes polarity (M1/M2) macrophages. MRS1754, a selective antagonist A2B receptor (A2BAR), attenuated decreased macrophage-myofibroblast transition DN rats. Therefore, we aimed investigate effect MRS1754 on glomerular...
We investigated the role of Drosophila larva olfactory system in identification congeners and aliens. discuss importance these activities navigation across substrates, implications for allocation space food among species similar ecologies. Wild type larvae cosmopolitan D. melanogaster endemic pavani, which cohabit same breeding sites, used species-specific volatiles to identify conspecifics aliens moving toward their species. gaucha larvae, a sibling pavani that is ecologically isolated from...