A5050135304- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Neuroscience and Neuropharmacology Research
- Connexins and lens biology
- Photoreceptor and optogenetics research
- Heme Oxygenase-1 and Carbon Monoxide
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Advanced Glycation End Products research
- Nicotinic Acetylcholine Receptors Study
- Retinal and Optic Conditions
- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Phosphodiesterase function and regulation
- Alzheimer's disease research and treatments
- Bat Biology and Ecology Studies
- Ophthalmology and Visual Health Research
- Circadian rhythm and melatonin
- International Law and Human Rights
- Retinopathy of Prematurity Studies
- Muscle metabolism and nutrition
- Cephalopods and Marine Biology
- Animal Behavior and Reproduction
- Comparative constitutional jurisprudence studies
University of Auckland
2015-2024
Brain Research New Zealand
2018-2023
Kettering University
2023
Memorial Sloan Kettering Cancer Center
2023
Universidad del Rosario
2015-2019
Instituto de Ecología
2009
X-Fab (Germany)
2009
Purpose: Drugs that regulate connexin43 (Cx43) gap junction channels can reduce the spread of injury and improve functional outcomes after nervous system trauma. In eye, Cx43 expression increases in choroid following light damage. The aim this study was to investigate whether hemichannel block could preserve retinal function postinjury. Methods: Light damage induced by exposure adult albino Sprague-Dawley rats 2700 Lux for 24 hours. Intravitreal injections a mimetic peptide blocker,...
Glutamate is a major neurotransmitter in the CNS but also key metabolite intimately coupled to amino acid production/degradation. We consider effect of inhibition two glutamate metabolic enzymes: glutamine synthetase (GS) and aspartate aminotransferase on retinal function assessed using electroretinogram photoreceptoral (a-wave) post-receptoral (b-wave) amplitudes. Quantitative immunocytochemistry was used assess levels within photoreceptors, ganglion Müller cells secondary GS inhibition....
New studies show that the retina also undergoes pathological changes during development of Alzheimer's disease (AD). While transgenic mouse models used in these previous have offered insight into this phenomenon, they do not model human sporadic AD, which is most common form. Recently, Octodon degus has been established as a AD. Degus display age-related cognitive impairment associated with Aβ aggregates and phosphorylated tau brain. Our aim for study was to examine expression AD-related...
Diabetic retinopathy is a vascular disease of the retina characterised by hyperglycaemic and inflammatory processes. Most animal models diabetic are hyperglycaemia-only that do not account for significant role inflammation plays in development disease. In present study, we data on establishment new model incorporates both hyperglycaemia inflammation. We hypothesized may trigger worsen environment. Pro-inflammatory cytokines, IL-1β TNF-α, were therefore injected into vitreous non-obese (NOD)...
The aim of this study is to correlate small dot hyper-reflective foci (HRF) observed in spectral domain optical coherence tomography (SD-OCT) scans an animal model hyperglycaemia with focal electroretinography (fERG) response and immunolabelling retinal markers. eyes showing signs diabetic retinopathy (DR) were imaged using SD-OCT. Areas HRF further evaluated fERG. Retinal areas enclosing the dissected serially sectioned, stained labelled for glial fibrillary acidic protein (GFAP) a...
One major goal of integrative and comparative biology is to understand explain the interaction between performance behavior animals in their natural environment. The Caviomorph, Octodon degu , a native rodent species from Chile, represents unique model study physiological behavioral traits, including cognitive sensory abilities. Degus live colonies have well-structured social organization, with mostly diurnal–crepuscular circadian activity pattern. More notable fact that captivity, they...
Today's students have increased expectations for flexible learning options and evidence-based practice resources to be available support curricular activities. We investigated: (i) the suitability of a static website teaching ocular anatomy physiology an interactive version with quiz self-assessment activities (ii) usefulness blended online in-lab environment teach in Optometry. administered survey compare responses optometry who had access website, those from previous year used version....
Purpose: To evaluate the long-term effect on inflammation and inflammasome activation of intravitreally delivered connexin43 mimetic peptide (Cx43MP) in saline or incorporated within nanoparticles (NPs) for treatment light-damaged rat eye. Methods: Light-induced damage to retina was created by exposure adult albino Sprague-Dawley rats intense light 24 hours. A single dose Cx43MP, Cx43MP-NPs, injected at 2 hours after onset damage. Fluorescein isothiocyanate (FITC)-labelled Cx43MP-NPs were...
The shift from a diurnal to nocturnal lifestyle in vertebrates is generally associated with either enhanced visual sensitivity or decreased reliance on vision. Within birds, most studies have focused differences the system across all birds respect nocturnality-diurnality. critically endangered Kakapo (Strigops habroptilus), parrot endemic New Zealand, an example of species that has evolved otherwise lineage, but nothing known about its' system. Here, we provide detailed morphological...
Diabetic retinopathy (DR), a microvascular complication of diabetes, is associated with pronounced inflammation arising from the activation nucleotide-binding and oligomerization domain-like receptor (NLR) protein 3 (NLRP3) inflammasome. Cell culture models have shown that connexin43 hemichannel blocker can prevent inflammasome in DR. The aim this study was to evaluate ocular safety efficacy tonabersat, an orally bioavailable blocker, protect against DR signs inflammatory non-obese diabetic...
Creatine and phosphocreatine are required to maintain ATP needed for normal retinal function development. The aim of the present study was determine distribution creatine transporter (CRT) gain insight how is transported into retina. An affinity-purified antibody raised against CRT applied adult vertebrate retinas mouse retina during Confocal microscopy used identify localization pattern as well co-localization patterns with a range neurochemical markers. Strong labeling seen in...