A5074769045- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Connexins and lens biology
- Endoplasmic Reticulum Stress and Disease
- Biochemical effects in animals
- Retinal Development and Disorders
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Mitochondrial Function and Pathology
- Memory and Neural Mechanisms
- RNA regulation and disease
- Genetics, Aging, and Longevity in Model Organisms
- Glaucoma and retinal disorders
- Chronic Lymphocytic Leukemia Research
- Neurological disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disorders and Treatments
- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- Laser Applications in Dentistry and Medicine
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
University of Valparaíso
2014-2024
Viña del Mar University
2018-2023
Valparaiso University
2006-2023
Research Network (United States)
2020
Johns Hopkins University
2012-2016
Contextual memory formation relies on the induction of new genes in hippocampus. A polymorphism promoter transcription factor XBP1 was identified as a risk for Alzheimer's disease and bipolar disorders. is major regulator unfolded protein response (UPR), mediating adaptation to endoplasmic reticulum (ER) stress. Using phenotypic screen, we uncovered an unexpected function cognition behavior. Mice lacking nervous system showed specific impairment contextual long-term potentiation (LTP),...
Alzheimer's disease (AD) is an age-related neurodegenerative disorder associated with progressive memory loss, severe dementia, and hallmark neuropathological markers, such as deposition of amyloid-β (Aβ) peptides in senile plaques accumulation hyperphosphorylated tau proteins neurofibrillary tangles. Recent evidence obtained from transgenic mouse models suggests that soluble, nonfibrillar Aβ oligomers may induce synaptic failure early AD. Despite their undoubted value, these rely on genetic...
Alteration in the buffering capacity of proteostasis network is an emerging feature Alzheimer's disease (AD), highlighting occurrence endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) main adaptive pathway to cope with folding stress at ER. Inositol-requiring enzyme-1 (IRE1) operates as a central ER sensor, enabling establishment and repair programs through control expression transcription factor X-box binding 1 (XBP1). To artificially enforce UPR AD brain, we developed...
The threshold for bidirectional modification of synaptic plasticity is known to be controlled by several factors, including the balance between protein phosphorylation and dephosphorylation, postsynaptic free Ca(2+) concentration NMDA receptor (NMDAR) composition GluN2 subunits. Pannexin 1 (Panx1), a member integral membrane family, has been shown form non-selective channels regulate induction as well hippocampal-dependent learning. Although Panx1 have suggested play role in excitatory...
Activity-dependent bidirectional modifications of excitatory synaptic strength are essential for learning and storage on new memories. Research plasticity has largely focused long-term potentiation (LTP) depression (LTD) mechanisms that rely the activation NMDA receptors. In principle, metabotropic glutamate receptors (mGluRs) also suitable to convert activity into intracellular signals modification. Indeed, dysfunction a form LTD depends Type I mGluRs (mGluR-LTD), but not NMDARs, been...
Pannexin1 hemichannels (Panx1 HCs) are found in the membrane of most mammalian cells and communicate intracellular extracellular spaces, enabling passive transfer ions small molecules. They involved physiological pathophysiological conditions. During apoptosis, C-terminal tail Panx1 is proteolytically cleaved, but permeability features their role cell death remain elusive. To address these topics, HeLa transfected with full-length human (fl-hPanx1) or truncated hPanx1 (Δ371hPanx1) were...
Objective Autosomal dominant centronuclear myopathy (AD-CNM) is a neuromuscular congenital disease caused by mutations in the DNM2 gene that encodes dynamin-2 (DNM2). The main clinical features of AD-CNM are progressive weakness and atrophy skeletal muscles. However, cognitive defects have also been reported, suggesting AD-CNM-causing might affect central nervous system (CNS). We recently demonstrated excitatory synaptic transmission occur brain transgenic knock-in (KI) mice harboring...
Crypt olfactory receptor neurons (ORNs) are a third type of chemosensory neuron along with ciliated and microvillous ORNs in the epithelium fishes, but their functional role is still unknown. To investigate odorant response properties possible transduction pathways, we recorded crypt ORN activity calcium imaging patch clamp technique its cell-attached mode combination agonist stimulation. Bile salts putative fish pheromones did not elicit responses either method, cells frequently responded...
New studies show that the retina also undergoes pathological changes during development of Alzheimer's disease (AD). While transgenic mouse models used in these previous have offered insight into this phenomenon, they do not model human sporadic AD, which is most common form. Recently, Octodon degus has been established as a AD. Degus display age-related cognitive impairment associated with Aβ aggregates and phosphorylated tau brain. Our aim for study was to examine expression AD-related...
Long-term potentiation (LTP) and long-term depression (LTD) are two forms of synaptic plasticity that have been considered as the cellular substrate memory formation. Although LTP has received considerable more attention, recent evidences indicate LTD plays also important roles in acquisition storage novel information brain. Pannexin 1 (Panx1) is a membrane protein non-selective channels which shown to modulate induction hippocampal plasticity. Animals lacking Panx1 or blockade precludes...
One major goal of integrative and comparative biology is to understand explain the interaction between performance behavior animals in their natural environment. The Caviomorph, Octodon degu , a native rodent species from Chile, represents unique model study physiological behavioral traits, including cognitive sensory abilities. Degus live colonies have well-structured social organization, with mostly diurnal–crepuscular circadian activity pattern. More notable fact that captivity, they...
Alzheimer's disease (AD) is the most common neurodegenerative disorder and leading cause of age-related dementia worldwide. Several models for AD have been developed to provide information regarding initial changes that lead degeneration. Transgenic mouse recapitulate many, but not all, features AD, likely because high complexity pathology. In this context, validation a wild-type animal model mimics neuropathological behavioral abnormalities necessary. previous studies, we reported Chilean...
Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one earliest events in Alzheimer´s disease (AD) and thought to be major cause cognitive deficits. These abnormalities rely on defects synaptic plasticity, a series manifested as activity-dependent modifications structure function. It has been reported that Pannexin1 (Panx1), non-selective channel implicated cell communication intracellular signaling, modulates induction excitatory plasticity under...
The impact of aging on cognitive capabilities varies among individuals ranging from significant impairment to preservation function par with younger adults. Research the neural basis for age-related memory decline has focused primarily CA1 region hippocampus. However, recent studies in elderly human and rodents indicate that individual differences are more strongly tied functional alterations CA3 circuits. To examine synaptic plasticity region, we used aged rats behaviorally characterized a...
Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen species (mROS) production and induce sustained increase in cytoplasmic Ca2+ concentration. These properties make promising therapeutic agent against pathological conditions entail oxidative dysregulation. Here, we studied whether N-methyl-D-aspartate...
Accumulation of amyloid-beta (Aβ) peptides is regarded as the hallmark neurodegenerative alterations in brain Alzheimer's disease (AD) patients. In eye, accumulation Aβ has also been suggested to be a trigger retinal mechanisms. Some pathological aspects associated with levels are synaptic dysfunction, neurochemical remodeling and glial activation, but these changes have not established retina animals accumulation. We employed Octodon degus which accumulated function age. This current study...
Alzheimer's disease (AD) is the main cause of dementia worldwide. Emerging non-invasive treatments such as photobiomodulation target mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was carried out evaluate effect transcranial light therapy (TLTC) on synaptic plasticity (SP) and functions in AD animal model. Twenty-three mice were separated into two general groups: APP/PS1 (ALZ) transgenic group a wild-type (WT) group. Each randomly...
Enhanced activity and overexpression of Pannexin 1 (Panx1) channels contribute to neuronal pathologies such as epilepsy Alzheimer’s disease (AD). The Panx1 channel ablation alters the hippocampus’s glutamatergic neurotransmission, synaptic plasticity, memory flexibility. Nevertheless, Panx1-knockout (Panx1-KO) mice still retain ability learn, suggesting that compensatory mechanisms stabilize their activity. Here, we show absence in adult brain promotes a series structural functional...