A5051786109- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience and Neuropharmacology Research
- Cardiovascular and Diving-Related Complications
- Connexins and lens biology
- Mitochondrial Function and Pathology
- Nicotinic Acetylcholine Receptors Study
- Cancer, Hypoxia, and Metabolism
Arturo Prat University
2015-2023
University of Valparaíso
2022
Enhanced activity and overexpression of Pannexin 1 (Panx1) channels contribute to neuronal pathologies such as epilepsy Alzheimer’s disease (AD). The Panx1 channel ablation alters the hippocampus’s glutamatergic neurotransmission, synaptic plasticity, memory flexibility. Nevertheless, Panx1-knockout (Panx1-KO) mice still retain ability learn, suggesting that compensatory mechanisms stabilize their activity. Here, we show absence in adult brain promotes a series structural functional...
Background: In chronic hypoxia (CH) and short-term intermittent (CIH) exposure, glycemia insulin levels decrease sensitivity increases, which can be explained by changes in glucose transport at skeletal muscles involving GLUT1, GLUT4, Akt, AMPK, as well GLUT4 translocation to cell membranes. However, during long-term CIH, there is no information regarding whether these occur similarly or differently than other types of exposure. This study evaluated the AMPK Akt location soleus lean rats...
Long-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using rat model, we examined whether this type of differed from in terms pulmonary artery remodeling and other features. Rats were subjected (CH,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>9</mml:mn></mml:math>) long-term (CIH2x2; 2 days hypoxia/2 normoxia,<mml:math...
There is growing evidence that exposure to hypoxia, regardless of the source, elicits several metabolic responses in individuals. These are constitutive and usually observed under hypoxia but vary according type exposure. The aim this review was describe involvement obesity lipid metabolism development high-altitude pulmonary hypertension acute mountain sickness chronic intermittent hypoxia. Overweight or obesity, which common individuals with long-term (high-altitude miners, shift workers,...
Hypobaric hypoxia under chromic conditions triggers hypoxic pulmonary vasoconstriction (HPV) and right ventricular hypertrophy (RVH). The role of zinc (Zn) is controversial remains unclear. We evaluated the effect Zn supplementation in prolonged hypobaric on HIF2α/MTF-1/MT/ZIP12/PKCε pathway lung RVH. Wistar rats were exposed to for 30 days randomly allocated into three groups: chronic (CH); intermittent (2 hypoxia/2 normoxia; CIH); normoxia (sea level control; NX). Each group was subdivided...
Both chronic hypoxia (CH) and long-term intermittent (CIH) exposure lead to right ventricular hypertrophy (RVH). Weight loss is an effective intervention improve cardiac function energy metabolism in hypertrophy. Likewise, caloric restriction (CR) also plays important role this cardioprotection through AMPK activation. We aimed determine the influence of body weight (BW) on RVH, related variables by comparing rats exposed both hypoxic conditions.Sixty male adult were separated into two...