A5024002940- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiovascular and Diving-Related Complications
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Mitochondrial Function and Pathology
- Nitric Oxide and Endothelin Effects
- Alzheimer's disease research and treatments
- Eicosanoids and Hypertension Pharmacology
- Pituitary Gland Disorders and Treatments
- Sexual Differentiation and Disorders
Arturo Prat University
2013-2024
Chronic intermittent hypoxia (CIH) and chronic (CH) are associated with high-altitude pulmonary hypertension (HAPH). Asymmetric dimethylarginine (ADMA), a NO synthase (NOS) inhibitor, may contribute to HAPH. This study assessed changes in the ADMA/NO pathway underlying mechanisms rat lungs following exposure CIH or CH simulated hypobaric chamber at 428 Torr. Twenty-four adult Wistar rats were randomly assigned three groups: CIH2x2 (2 days of hypoxia/2 normoxia), CH, NX (permanent for 30...
Background: Prolonged exposure to altitude-associated chronic hypoxia (CH) may cause high-altitude pulmonary hypertension (HAPH). Chronic intermittent hypobaric (CIH) occurs in individuals who commute between sea level and high altitude. CIH is associated with repetitive acute hypoxic acclimatization conveys the long-term risk of HAPH. As nitric oxide (NO) regulates vascular tone asymmetric dimethylarginine (ADMA) an endogenous inhibitor NO synthesis, we investigated whether ADMA...
Background: In chronic hypoxia (CH) and short-term intermittent (CIH) exposure, glycemia insulin levels decrease sensitivity increases, which can be explained by changes in glucose transport at skeletal muscles involving GLUT1, GLUT4, Akt, AMPK, as well GLUT4 translocation to cell membranes. However, during long-term CIH, there is no information regarding whether these occur similarly or differently than other types of exposure. This study evaluated the AMPK Akt location soleus lean rats...
One of the consequences high altitude (hypobaric hypoxia) exposure is development right ventricular hypertrophy (RVH). particular type long-term chronic intermittent hypobaric hypoxia (CIH); molecular alterations in RVH this condition are less known. Studies show an important role nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex-induced oxidative stress and protein kinase activation different models cardiac hypertrophy. The aim was to determine level, NADPH expression MAPK...
There is growing evidence that exposure to hypoxia, regardless of the source, elicits several metabolic responses in individuals. These are constitutive and usually observed under hypoxia but vary according type exposure. The aim this review was describe involvement obesity lipid metabolism development high-altitude pulmonary hypertension acute mountain sickness chronic intermittent hypoxia. Overweight or obesity, which common individuals with long-term (high-altitude miners, shift workers,...
Both chronic hypoxia (CH) and long-term intermittent (CIH) exposure lead to right ventricular hypertrophy (RVH). Weight loss is an effective intervention improve cardiac function energy metabolism in hypertrophy. Likewise, caloric restriction (CR) also plays important role this cardioprotection through AMPK activation. We aimed determine the influence of body weight (BW) on RVH, related variables by comparing rats exposed both hypoxic conditions.Sixty male adult were separated into two...
In Chile, individuals are commonly exposed to high altitude due the work shift system, involving days of exposure followed by at sea level over long term, which can result in chronic intermittent hypobaric hypoxia (CIHH). CIHH cause high-altitude pulmonary hypertension (HAPH), principal manifestation is right ventricular hypertrophy (RVH), some cases leading heart failure and eventually death. Studies have shown contribution oxidative stress inflammation RVH development. Recently, it was...
Introduction: Hypoxia, either from altitude or clinical ailments is associated with pathophysiological conditions like mountain sickness and/or hypoxia-induced pulmonary hypertension. An endothelial dysfunction plays a crucial role in the manifestation of these diseases. Asymmetric dimethylarginine (ADMA) an endogenous formed NO synthase (NOS) inhibitor and well known as risk factor for respiratory diseases dysfunction. ADMA metabolized by dimethylaminohydrolases (DDAH). Our study was aimed...
Introduction: Chronic Hypoxia (CH) as well chronic intermittent hypoxia (CIH) are associated with pathophysiological conditions like acute/chronic mountain sickness and pulmonary hypertension. In the manifestation of these diseases endothelium L-arginine/NO pathway plays a crucial role. Asymmetric dimethylarginine (ADMA) is an endogenous formed NO synthase (NOS) inhibitor known risk factor for respiratory endothelial dysfunction in circulation. ADMA metabolized by dimethylaminohydrolases...
Abstract Prolonged exposure to altitude-associated chronic hypoxia (CH) may cause high altitude pulmonary hypertension (HAPH). Chronic intermittent hypobaric (CIH) occurs in individuals who commute between sea level and altitude. CIH is associated with repetitive acute hypoxic acclimatization conveys the long-term risk of HAPH. As nitric oxide (NO) an important regulator systemic vascular tone asymmetric dimethylarginine (ADMA) endogenous inhibitor NO synthesis that increases hypoxia, we...