A5084534209- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Retinal Development and Disorders
- Child Development and Digital Technology
- Advanced Memory and Neural Computing
- Cellular transport and secretion
- Memory and Neural Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Vestibular and auditory disorders
- Sleep and Wakefulness Research
- Connexins and lens biology
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Analysis and Sensing Techniques
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- PI3K/AKT/mTOR signaling in cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Fractal and DNA sequence analysis
- Angiogenesis and VEGF in Cancer
- Receptor Mechanisms and Signaling
- Multiple Myeloma Research and Treatments
- Cancer, Hypoxia, and Metabolism
Chengdu Women's and Children's Central Hospital
2022-2025
University of Electronic Science and Technology of China
2022-2025
Hubei University of Arts and Science
2022-2023
Xiangyang Central Hospital
2022-2023
Hussman Institute for Autism
2015-2021
Allen Institute for Brain Science
2020-2021
Johns Hopkins University
2010-2021
University of Maryland, College Park
2013
Chinese Academy of Sciences
2004-2007
Shanghai Institutes for Biological Sciences
2004-2007
Dark exposure initiated in adulthood reactivates robust ocular dominance plasticity the visual cortex. Here, we show that a critical component of response to dark is rejuvenation inhibitory synaptic transmission, resulting decrease functional density, paired-pulse depression, and reexpression endocannabinoid-dependent long-term depression (iLTD). Importantly, pharmacological acceleration maturation inhibition dark-exposed adults inhibits iLTD reactivation plasticity. Surprisingly, earlier...
In pyramidal cells, the induction of spike-dependent plasticity (STDP) follows a simple Hebbian rule in which order presynaptic and postsynaptic firing dictates LTP or LTD. contrast, cortical fast spiking (FS) interneurons, control rate timing cell firing, reportedly express timing-dependent LTD, but not LTP. Because mismatch STDP rules could impact maintenance excitation/inhibition balance, we examined neuromodulation FS cells mouse visual cortex. We found that stimulation adrenergic...
In primates, the functional connectivity of adult primary visual cortex is susceptible to be modified by sensory training during perceptual learning. It widely held that this type neural plasticity might involve mechanisms like long-term potentiation (LTP) and depression (LTD). NMDAR-dependent forms LTP LTD are particularly attractive because in rodents they can induced a Hebbian manner near coincidental presynaptic postsynaptic firing, paradigm termed spike timing-dependent (STDP). These...
Metaplasticity, the adaptive changes of long-term potentiation (LTP) and depression (LTD) in response to fluctuations neural activity is well documented visual cortex, where dark rearing shifts frequency threshold for induction LTP LTD. Here we studied metaplasticity affecting spike-timing-dependent plasticity, which polarity plasticity determined not by stimulation frequency, but temporal relationship between near-coincidental presynaptic postsynaptic firing. We found that mouse cortex same...
To investigate the factors affecting chemotherapy efficacy following first relapse in pediatric B-cell acute lymphoblastic leukemia (B-ALL). A retrospective investigation was conducted on clinical data from 254 patients with B-ALL treated at First Affiliated Hospital of Xinjiang Medical University, Red Star 13th Division Production and Construction Corps Chengdu Women's Children's Central between August 2016 September 2022. Patients were divided into a Good Response (GR) group Poor (PR)...
Abstract GABA released from presynaptic sites induces short-lived phasic inhibition mediated by synaptic A receptors (GABA Rs) and longer-duration tonic extrasynaptic or B Rs). number of studies have found that contactin-associated protein 2 (Cntnap2) knockout (KO) mice, a well-established mouse model autism, exhibit reduced interneuron numbers aberrant inhibition. However, little is known about whether disrupted in Cntnap2 KO mice when the disruption begins to occur during postnatal...
Synapses are intrinsically 'noisy' in that neurotransmitter is occasionally released the absence of an action potential. At inhibitory synapses, frequency potential-independent release orders magnitude higher than at excitatory synapses raising speculations it may serve a function. Here we report synaptic 'noise' (i.e. miniature postsynaptic currents, mIPSCs) highly regulated by sensory experience visual cortex. Importantly, regulation mIPSC so far predominant form functional plasticity...
Tonic inhibition mediated by extrasynaptic GABA A receptors (GABARs) sensing ambient levels of can profoundly alter the membrane input resistance to affect cellular excitability. Therefore, regulation tonic is an attractive mechanism control cortical firing. In pyramidal cells, regulated age and several neurotransmitters affected stroke epilepsy. However, possible role sensory experience has not been examined. Here, we report that a brief 2-day exposure dark reduces 1/3 inhibitory...
Abstract Disrupted GABAergic neurons have been extensively described in brain tissues from individuals with autism spectrum disorder (ASD) and animal models for ASD. However, the contribution of these aberrant inhibitory to autism-related behavioral phenotypes is not well understood. We examined ASD-related behaviors mice conditional Pten knockout parvalbumin (PV)-expressing or somatostatin (Sst)-expressing neurons, two common subtypes neurons. found that deletion either PV-neurons...
Autism spectrum disorder (ASD) is a neurologic condition characterized by alterations in social interaction and communication, restricted and/or repetitive behaviors. The classical Type II cadherins cadherin-8 (Cdh8, CDH8) cadherin-11 (Cdh11, CDH11) have been implicated as autism risk gene candidates. To explore the role of etiology autism, we investigated their expression patterns during mouse brain development autism-specific human tissue. In mice, was developmentally regulated enriched...
Abstract Tomosyn, a protein encoded by syntaxin‐1‐binding 5 ( STXBP5 ) gene, has well‐established presynaptic role in the inhibition of neurotransmitter release and reduction synaptic transmission its canonical interaction with soluble N ‐ethylmaleimide‐sensitive factor attachment receptor machinery. However, postsynaptic tomosyn dendritic arborization, spine stability, trafficking ionotropic glutamate receptors remains to be elucidated. We used short hairpin RNA knock down mouse primary...
Significance We report a unique form of neural plasticity in the visual cortex. Unlike well-known forms plasticity, which synaptic connections are slowly weakened or strengthened, we found that deprivation causes rapid and transient “all-or-none” loss local between pyramidal cells parvalbumin-positive interneurons (Pyr→PV). After 1 d deprivation, half these lost, whereas spared ones remain unchanged; after 2 connectivity levels return to normal. Finally, show this early all-or-none Pyr→PV is...
Altered neuronal connectivity has been implicated in the pathophysiology of Autism Spectrum Disorder (ASD). SLIT/ROBO signaling plays an important role developmental processes connectivity, including axon guidance, migration, and axonal dendritic branching. Genetic evidence supports that SLIT3, one genes encoding SLITs, is associated with ASD. Yet causal link between SLIT3 mutation autism symptoms not examined. Here we assessed ASD-associated behaviors Slit3 knockout (KO) mice. Our data...
Neuromodulatory systems are essential for remodeling glutamatergic connectivity during experience-dependent cortical plasticity. This permissive/enabling function of neuromodulators has been associated with their capacity to facilitate the induction Hebbian forms long-term potentiation (LTP) and depression (LTD) by affecting cellular network excitability. In vitro studies indicate that also affect expression plasticity in a pull-push manner: receptors coupled G-protein Gs promote LTP at...
Objectives: We investigated the effects of macrophage migration inhibitory factor (MIF) knockdown or overexpression combined with ultraviolet radiation B (UVB) irradiation on cell proliferation and apoptosis oral squamous carcinoma (OSCC). Methods: MIF expression in OSCC adjacent tissues was detected by immunohistochemistry. human immortalized epithelial cells (HIOEC) western blotting. knocked down overexpressed lines (SCC-25 CAL-27). were set up into control (CON), overexpression/knockdown...
Radio-resistance is a leading cause of nasopharyngeal carcinoma (NPC) treatment failure and identification sensitising therapeutic targets an unmet need to enhance clinical management. Given that the mammalian target rapamycin (mTOR) signalling confers resistance cancer therapy, we investigated whether mTOR contributes radio-resistance in NPC pharmacological inhibition can overcome radio-resistance. We found mRNA protein levels, phosphorylation its downstream effector were increased...
Fura-2 fluorescent calcium imaging was used for analyzing the subtype of AMPA receptors in freshly dissociated horizontal cells carp retina. Exogenous application induced an increase intracellular concentration free Ca2+ ([Ca2+]i) cells, while [Ca2+]i partly inhibited by nifedipine. The residual completely eliminated joro spider toxin-3, a blocker Ca2+-permeable receptors. On other hand, pentobarbital, which blocked Ca2+-impermeable receptors, could also inhibit [Ca2+]i, implying that...
Parvalbumin-expressing fast-spiking interneurons (PV-INs) control network firing and the gain of cortical response to sensory stimulation. Crucial for these functions, PV-INs can sustain high-frequency with no accommodation. However, also exhibit short-term depression (STD) during sustained activation, largely due depletion synaptic resources (vesicles). In most synapses rate replenishment depleted vesicles is constant, determining an inverse relationship between levels activation rate,...
Fura-2 fluorescent calcium imaging was applied to measure [Ca2+]i in freshly dissociated horizontal cells of carp retina, and a model containing endoplasmic reticulum (ER) membrane processes plasma constructed for quantitative analyses the AMPA-triggered dynamics. A transient increase followed by sustained steady level observed when 100 μM AMPA applied, while initial suppressed exogenously ryanodine. The results suggest that dynamics involves number cytoplasmic interact with each other. It...