A5000601309- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Biochemical effects in animals
- Cellular transport and secretion
- Connexins and lens biology
- Diet and metabolism studies
- Animal Behavior and Reproduction
- Neurobiology and Insect Physiology Research
- Endoplasmic Reticulum Stress and Disease
- Alzheimer's disease research and treatments
- Analytical Chemistry and Chromatography
- Autophagy in Disease and Therapy
- Chemical Reactions and Mechanisms
- RNA regulation and disease
- Insect and Arachnid Ecology and Behavior
- Genetic Neurodegenerative Diseases
- Inorganic and Organometallic Chemistry
Pontificia Universidad Católica de Chile
2021-2023
University of Chile
1981-2023
Instituto de Neurociencia Biomédica
2023
University of Valparaíso
2017-2020
Brain activity is constrained by local availability of chemical energy, which generated through compartmentalized metabolic processes. By analyzing data whole human brain gene expression, we characterize the spatial distribution seven glucose and monocarboxylate membrane transporters that mediate astrocyte–neuron lactate shuttle transfer energy. We found coding for neuronal MCT2 only enriched in cerebral cortex where its abundance inversely correlated with cortical thickness. Coexpression...
Long-term potentiation (LTP) and long-term depression (LTD) are two forms of synaptic plasticity that have been considered as the cellular substrate memory formation. Although LTP has received considerable more attention, recent evidences indicate LTD plays also important roles in acquisition storage novel information brain. Pannexin 1 (Panx1) is a membrane protein non-selective channels which shown to modulate induction hippocampal plasticity. Animals lacking Panx1 or blockade precludes...
Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one earliest events in Alzheimer´s disease (AD) and thought to be major cause cognitive deficits. These abnormalities rely on defects synaptic plasticity, a series manifested as activity-dependent modifications structure function. It has been reported that Pannexin1 (Panx1), non-selective channel implicated cell communication intracellular signaling, modulates induction excitatory plasticity under...
Abstract Aims Dynamin‐2 is a large GTPase, member of the dynamin superfamily that regulates membrane remodelling and cytoskeleton dynamics. Mutations in dynamin‐2 gene ( DNM2 ) cause autosomal dominant centronuclear myopathy (CNM), congenital neuromuscular disorder characterised by progressive weakness atrophy skeletal muscles. Cognitive defects have been reported some ‐linked CNM patients suggesting these mutations can also affect central nervous system (CNS). Here we studied how...
Abstract β‐Pinene and epichlorohydrin (ECH) have been copolymerized cationically using BF 3 (C 2 H 5 ) O SnCl 4 as catalysts. Polymerizations were carried out at −80°C in methylenechloride. Monomer reactivity ratios determined both catalysts which r 1 = 1.06 ± 0.15 (β‐pinene) 0.32 0.08 0.33 0.11 2.03 0.44 . Copolymers of different composition soluble acetone insoluble methanol. This characteristic was taken to indicate that the polymeric products real copolymers not a mixture two...
Abstract Dynamin-2 is a large GTP-ase, member of the dynamin superfamily, that regulates membrane remodeling and cytoskeleton dynamics. In mammalian nervous system dynamin-2 modulates synaptic vesicle (SV)-recycling at nerve terminals receptor-trafficking to from postsynaptic densities (PSDs). Mutations in cause autosomal dominant centronuclear myopathy (CNM), congenital neuromuscular disorder characterized by progressive weakness atrophy distal skeletal muscles. Cognitive defects have also...