A5042555918- Analytical Chemistry and Chromatography
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Neuroblastoma Research and Treatments
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Analytical Methods in Pharmaceuticals
- Analytical chemistry methods development
- Various Chemistry Research Topics
- Electrochemical Analysis and Applications
- Dermatological and Skeletal Disorders
- Chemical and Physical Properties in Aqueous Solutions
- T-cell and B-cell Immunology
- Amino Acid Enzymes and Metabolism
- Water Quality Monitoring and Analysis
- Systemic Sclerosis and Related Diseases
- Chemical Synthesis and Analysis
- Melanoma and MAPK Pathways
- Mass Spectrometry Techniques and Applications
- Arsenic contamination and mitigation
- Chemical Reactions and Isotopes
- Autoimmune Bullous Skin Diseases
- History and advancements in chemistry
Ghent University
1976-2024
Cancer Research Institute Ghent
2022-2024
University of Gothenburg
2024
Ghent University Hospital
1981-2023
Centre Hospitalier Universitaire de Grenoble
2012-2018
Université Grenoble Alpes
2018
Hôpital Nord
2014-2015
Centre Hospitalier Annecy Genevois
2012
Agroécologie
2012
Centre Hospitalier Régional et Universitaire de Nancy
2011
Abstract We report a fast, simple high-performance liquid-chromatographic assay for serum alpha-tocopherol, with use of reversed-phase column and tocol as internal standard. Only 200 microliter is required. Isocratic elution the n-hexane extract done within 6 min; total analysis time less than 1 h. Within-day precision (CV) was 2.3% 24 samples normal plasma pool (mean concn, 10.1 mg/liter). Day-to-day 3.2%, measured 20 days specimen concentration 10.8 mg/liter. Analytical recovery...
High-risk neuroblastoma (NB) is responsible for a disproportionate number of childhood deaths due to cancer.One indicator highrisk NB amplification the neural MYC (MYCN) oncogene, which currently therapeutically intractable.Identification anaplastic lymphoma kinase (ALK) as an oncogene raised possibility using ALK tyrosine inhibitors (TKIs) in treatment patients with activating mutations.8-10% primary are ALK-positive, figure that increases relapsed population.ALK activated by ALKAL2 ligand...
The Human Leukocyte Antigen (HLA) genes are a group of highly polymorphic that located in the Major Histocompatibility Complex (MHC) region on chromosome 6. HLA genotype affects presentability tumour antigens to immune system. While knowledge these genotypes is utmost importance study differences responses between cancer patients, gold standard, PCR-derived rarely available large Next Generation Sequencing (NGS) datasets. Therefore, variety methods for silico NGS-based genotyping have been...
High-risk neuroblastoma (NB) often involves MYCN amplification as well mutations in ALK. Currently, high-risk NB presents significant clinical challenges, and additional therapeutic options are needed. Oncogenes like ALK result increased replication stress cancer cells, offering therapeutically exploitable options. We have pursued phosphoproteomic analyses highlighting ATR activity ALK-driven identifying the BAY1895344 inhibitor a potent of cell growth proliferation. Using RNA-Seq,...
Journal Article Effects of hyperthermia on cisplatin tissue penetration and gene expression in peritoneal metastases: results from a randomized trial ovarian cancer Get access Jesse Demuytere, Demuytere Department GI Surgery, Ghent University Hospital, Ghent, BelgiumLaboratory Experimental University, BelgiumCancer Research Institute (CRIG), Belgium https://orcid.org/0000-0003-0096-2798 Search for other works by this author on: Oxford Academic Google Scholar Charlotte Carlier, Carlier...
Cancer is driven by somatic mutations that result in a cellular fitness advantage. This selective advantage expected to be counterbalanced the immune system when these driver simultaneously lead generation of neoantigens, novel peptides are presented at cancer cell membrane via HLA molecules from MHC complex. The presentability determined patient’s genotype and it has been suggested this results genotype-specific restrictions oncogenic mutational landscape. Here, we generated set virtual...
Lower-limb ulcers in systemic sclerosis patients are rarely reported. The aim of this study was to describe the main causes and outcomes lower-limb assess factors associated with ischaemic (arterial disease and/or microvascular impairment). A retrospective, multicentre, case-control conducted 2013 2014, including 45 presenting between 2008 2013. estimated prevalence among 12.8%. Ulcers were related venous insufficiency 22 cases (49%), 21 (47%) other 2 (4%). Complete healing observed 60% a...
Neuroblastoma (NB) is the most common cancer in infancy with an urgent need for more efficient targeted therapies. The development of novel (combinatorial) treatment strategies relies on extensive explorations signaling perturbations neuroblastoma cell lines, using RNA-Seq or other high throughput technologies (e.g. phosphoproteomics). This typically requires dedicated bioinformatics support, which not always available. Additionally, while data from published studies are highly valuable and...
Owing to the lack of sensitivity and/or selectivity existing chemical assays, vitamin K deficiency has always been diagnosed indirectly by measuring its effect o n .blood coagulation.We used our recently developed multidimensional liquid chromatographic assay for what is, best knowledge, first systematic investigation physiological levels in human blood.It allowed unequivocal demonstration trans-phylloquinone (vitamin K,) and quantification down a level 0.5 nanogram per milliliter serum...
A liquid-chromatographic assay for alpha, beta, and gamma-isomeric tocopherols in human serum is reported. The the internal standard (tocol) are absorbed into a silica gel column eluted less than 10 min with n-hexane/isopropanol (99.4/0.6, by vol) at flow rate of 1 mL/min. complete analysis requires no longer 30 min. Within-day precision (CV) was 1.4% (mean = 13.18 mg/L, n 24), 7.4% 0.214 14), 1.3% 1.01 14) alpha-, beta-, gamma-tocopherol, respectively. Day-to-day 4.4% 9.85 10)...
Abstract Nous avons étudié le dosage des thiosulfates par l'hypobromite en excès milieu alcalin. Les solutions d'hypobromite de soude, préparées à partir d'une solution bromate‐bromure sont caractérisées une parfaite stabilité. La standardisation est effectuée voie iodométrique et donne résultats fort satisfaisants. Enfin, la détermination thiosulfate addition titration cet iodométrie bons résultats, qui deviennent excellents pour décinormales Comme ceux‐ci l'ordre 0,01 M, méthode proposée...
Abstract Nous avons étudié le dosage du sulfocyanure de potassium par titrage à l'hypobromite. La standardisation l'hypobromite, solution stable pendant au moins un mois préparée partir d'un mélange adéquat bromate et bromure, est effectuée voie iodométrique. détermination différentes solutions addition d'hypobromite en excès milieu alcalin cet iodométrie (addition d'iodure, acidification d'iode formé thiosulfate) donne d'excellents résultats avec une précision 0,15%. Comme 8 electrons sont...
Abstract Les erreurs mentionnées dans différentes méthodes employant de l'hypobromite, et attribuées à la présence divers composés solution oxydante, nous a amené une étude théorique générale concernant l'emploi d'une oxydante composée. A l'aide données graphiques en se basant sur l'inclinaison des droites obtenues, il est possible calculer le nombre d'électrons échangés l'oxydation milieu alcalin acide. En plus, composition peut être déterminée du point d'intersection droites. mêmes...