A5050474601- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Gastric Cancer Management and Outcomes
- Mechanical Circulatory Support Devices
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Cardiac Structural Anomalies and Repair
- Hepatitis C virus research
- Colorectal Cancer Surgical Treatments
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Artery Anomalies
- Esophageal Cancer Research and Treatment
- RNA and protein synthesis mechanisms
- Esophageal and GI Pathology
- RNA modifications and cancer
- Data Visualization and Analytics
- Infective Endocarditis Diagnosis and Management
- Topological and Geometric Data Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Medication Adherence and Compliance
- Consumer Market Behavior and Pricing
- Polyomavirus and related diseases
- Hemostasis and retained surgical items
Massachusetts General Hospital
2019-2025
Harvard University
2019-2025
Texas State University
2022
University of California, Berkeley
2022
Brigham and Women's Hospital
2020
University of Kentucky
2018
Metastasis: A matter of translation? Solid tumors shed a small number cancer cells into the bloodstream, some which are believed to contribute metastasis. The molecular features that confer these circulating tumor (CTCs) with metastatic potential poorly understood. Ebright et al. studied CTCs from breast patients and found increased expression levels certain ribosomal proteins regulators translation had greater capacity in mouse model (see Perspective by Ma Jeffrey). Consistent this finding,...
Ex vivo machine perfusion or normothermic is a preservation method that has gained great importance in the transplantation field. Despite immense opportunity for assessment due to beating state of heart, current clinical practice depends on limited metabolic trends graft evaluation. Hemodynamic measurements obtained from left ventricular loading have garnered significant attention within field their potential as objective parameters. In effect, this protocol provides an easy and effective...
Adequate and durable recovery in patients supported with venoarterial (VA) extracorporeal membrane oxygenation (ECMO) can be challenging to predict. Extracorporeal weaning is the process by which ECMO flows are decreased assess if a patient ready for decannulation. The optimal strategies deciding who wean how VA remain undefined. A retrospective literature review was performed understand evidence supporting current practices particular selection methods. Most published work expert opinions...
ObjectiveTo examine trends in utilization of hearts from hepatitis C virus (HCV) viremic donors for transplantation, a strategy to expand organ availability.MethodsThe United Network Organ Sharing (UNOS) registry was queried adult patients undergoing heart transplantation between 2015 and 2019. We excluded multiorgan transplants, incomplete data, loss follow-up. Nucleic acid testing (NAT) defined HCV status.ResultsBetween 2019, total 11,393 adults underwent transplantation: 326 NAT+ 11,067...
Abstract OBJECTIVES Post-lobectomy bleeding is uncommon and rarely studied. In this study, we aimed to determine the incidence of post-lobectomy haemorrhage compare outcomes reoperation non-operative management. METHODS We conducted a single-institution review lobectomy cases from 2009 2018. The patients were divided into two groups based on treatment for postoperative bleeding: or transfusion packed red blood cells with observation. Transfusion correcting intraoperative loss was excluded....
Background. The number of patients waiting for heart transplant far exceeds the hearts available. Donation after circulatory death (DCD) combined with machine perfusion can increase transplantable by as much 48%. Emerging studies also suggest could enable allograft “reconditioning” to optimize outcomes. However, a detailed understanding energetic substrates and metabolic changes during is lacking. Methods. Metabolites were analyzed using 1-dimensional 1 H 2-dimensional 13 C- heteronuclear...
Objective: This manuscript describes the rationale and design of a randomized, controlled trial comparing outcomes with Warfarin vs Novel Oral Anticoagulant (NOAC) therapy in patients new onset atrial fibrillation after cardiac surgery. Background: New commonly occurs surgery is associated increased rates stroke mortality. nonsurgical fibrillation, NOACs have been shown to confer equivalent benefits for prevention less bleeding risk tedious monitoring requirements compared Warfarin. However,...
Organ preservation in heart transplantation is key to preventing primary graft dysfunction, the most common cause of early loss. Historically, standard care was on ice, with no monitoring ability and problems even temperature distribution. Recently, SherpaPak, an FDA-approved transport device, has emerged as a solution these two issues, allowing for distribution, organ contact continuous during transport. This method falls under static cold preservation, but may allow longer ischemic times...