A5038373087- Head and Neck Cancer Studies
- Tracheal and airway disorders
- Head and Neck Surgical Oncology
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Cleft Lip and Palate Research
- Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Airway Management and Intubation Techniques
- Obstructive Sleep Apnea Research
- Meningioma and schwannoma management
- Management of metastatic bone disease
- MicroRNA in disease regulation
- Esophageal and GI Pathology
- Bone Tumor Diagnosis and Treatments
- Proteoglycans and glycosaminoglycans research
- Cancer-related gene regulation
- Soft tissue tumor case studies
- Vascular Anomalies and Treatments
- Titanium Alloys Microstructure and Properties
- Cancer survivorship and care
Monash Health
2016-2022
Monash University
2008-2022
Monash Institute of Medical Research
2021
Hudson Institute of Medical Research
2016-2017
Monash Medical Centre
2004-2017
Beaumont Hospital
2011
Northern Health
2009
Hôpital Européen Georges-Pompidou
2006
Université Paris Cité
2005-2006
<h3>Objectives</h3> To assess local control of early-stage glottic cancer by laser cordectomy in comparison with previously published external partial laryngectomy series and to determine the relevance histological margins cancers excised cordectomy. <h3>Design</h3> Retrospective review for carcinoma situ (Tis) stage T1 from January 1991 2004. <h3>Setting</h3> University hospital. <h3>Patients</h3> Fifty-two patients Tis or cancer. <h3>Intervention</h3> Endoscopic cordectomy, classified...
CDKN2A ( p16) disruption is reported as a frequent event in head and neck squamous cell carcinomas that confers poor prognosis. We investigated the frequency of different potential mechanisms inactivation oral tongue (OTSCC) their impact on patient outcome. From cohort 153 OTSCC patients, 131 formalin fixed paraffin embedded blocks pre‐treatment primary tumours were suitable for further molecular analysis. assessed (p16) levels by immunohistochemistry (IHC), promoter methylation status...
Experimental paradigms provide the framework for understanding of cancer, and drive research treatment, but are rarely considered by clinicians. The somatic mutation theory (SMT), in which cancer is a genetic disease, has been predominant traditional model over 50 years. More recently, alternative theories have proposed, such as tissue organization field (TOFT), evolutionary models, inflammatory models. Key concepts within various models led to them being difficult reconcile. Progressively,...
Background: The role of fine‐needle aspiration (FNA) in salivary gland lesions as a preoperative diagnosis has always been under scrutiny. Several studies have shown that frozen section (FS) is accurate for pathological and decision‐making during the surgery. This study carried out to assess accuracy FNA FS parotid surgeries. Methods: All removed between July 1998 June 2003 by Department Otolaryngology, Head Neck unit at Monash Medical Centre were reviewed. FNA, definitive pathology...
The presence of cervical lymph node metastasis is an important prognostic factor for patients with head and neck squamous cell carcinomas (HNSCC). Accurate assessment in these essential appropriate management purposes. Here, we evaluated the effectiveness maximum standardized uptake value (SUVmax) on positron emission tomography (PET) assessing HNSCC prior to surgery. A retrospective review 74 who underwent PET/CT dissection were examined. Pre-operative scans reviewed by two experienced...
DNA hypermethylation is reported as a frequent event and prognostic marker in head neck squamous cell carcinomas (HNSCC). Methylation has been commonly assessed with non-quantitative methodologies, such methylation-specific PCR (MSP). We investigated previously hypermethylated genes quantitative methodology oral tongue (OTSCC).The methylation status of 12 115 OTSCC samples was by one or more three analyses: sensitive high resolution melting (MS-HRM), sensitive-melting analysis after real...
Abstract Background Oropharyngeal squamous cell carcinoma (OPSCC) is often diagnosed at an advanced stage because the disease causes minimal symptoms other than metastasis to neck lymph nodes. Better tools are required assist with early detection of OPSCC. MicroRNAs (miRNAs, miRs) potential biomarkers for head and cancer diagnosis, prognosis, recurrence, presence metastatic disease. However, there no widespread agreement on a panel miRNAs clinically meaningful utility cancers. This could be...
Abstract Objective: To assess the long‐term results of dilatation and our experience with for assisted ventilation‐induced laryngotracheal stenosis. Design: A retrospective study 32 patients primarily treated stenosis between 1977 2002. Setting: tertiary care center university teaching hospital. Patients: There were 19 men 13 women aged 15 to 76 years. The was cicatricial some inflammatory process in 27 completely mature 5 patients. involved cricoid trachea four In 28 patients, only trachea....
The only alloy currently utilized for additive manufacture of bone implants, Ti–6Al–4V, has a high elastic modulus and bioinert surface, potentially inducing stress shielding hindering osseointegration. Low-modulus materials with bioactive surfaces could significantly reduce implant failure rates by improving the interaction between implants surrounding bone. In this study, laser powder bed fusion Ti25Ta Ti65Ta alloys, highlighted previously their low moduli, were assessed surface osteogenic...
Concha bullosa, an extensively pneumatized middle turbinate, may obstruct the paranasal sinuses. Messerklinger's partial lateral turbinectomy is commonly used to debulk concha leaving a raw surface with potential for adhesions.A modified technique of described. A posterior pedicled mucosal flap covers inferior medial lamella turbinate. Three-month follow up consecutive series compared concurrent controls.Two (7 per cent) 28 and four (21 19 traditional turbinectomies developed mild meatal...
Abstract Background: Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of dissection, investigate if age, gender, body mass index, tumour size, depth invasion p16 status influence yield. Method: A retrospective review 185 patients with carcinoma generated 240 dissection specimens. Results: The respective mean yields for levels I, II, III, IV V were 5.27, 9.43, 8.49, 7.43 9.02...
Background: Quality of life (QoL) outcomes after paediatric tonsillectomy can be assessed with disease-specific patient reported outcome measures. Our aim was to assess a modified T-14 Paediatric Throat Disorders Outcome Test in an Australian population undergoing tonsillectomy. Methods: A consecutive case series conducted children (aged 1–16 years) over period 15 months. questionnaires administered the caregivers child pre-operatively and post-operatively (n=45) within 6–8 weeks procedure...
Objective: We present a case of tonsillar schwannoma occurring in the youngest patient described English literature. Results: An eight year old girl was found to have 12 month history slowly progressive dysphagia and two rapidly enlarging right sided oropharyngeal mass. A tonsillectomy performed while there an involved margin, MRI post excision showed no residual tumour or abnormal enhancement. The final histology demonstrated lesion be schwannoma. Conclusion: This represents important...
Oncocytomas are rare tumours that occur predominantly in the major salivary glands, particularly parotid of older individuals. We present exceptionally occurrence an oncocytoma post-nasal space and its treatment for first time via a Le Fort I osteotomy. The potential local spread to surrounding skull base makes it vital achieve good oncological clearance. found this was possible using technique would recommend approach should be considered future, when approaching such lesions.
ABSTRACT Background Margins in head and neck squamous cell carcinoma (HNSCC) are determined by morphological changes assessed via hematoxylin‐eosin staining. Physiological may not be detected this technique. The purpose of study was to determine if a protein biomarker, laminin‐332γ2, overexpressed cancer cells at the invasive front HNSCC, remains unaffected heat produced during resection, supporting role for immunohistochemistry assessment margins. Methods Archived tissue blocks from glottic...
Abstract Background CO 2 transoral laser surgery and radiotherapy are both recognized as acceptable treatments for early glottic squamous cell carcinoma ( SCC ) with similar rates of cure. The reasons why some the patients in our series undergoing resection their primary modality treatment subsequently underwent or chemoradiotherapy will be discussed. Methods Retrospective study between J anuary 2003 A ugust 2010 all T1 T2 SCCs treated at a major tertiary centre. T is lesions were excluded....
Abstract Introduction Concurrent chemoradiotherapy with high‐dose (HD) cisplatin is the standard treatment for locally advanced head and neck squamous cell carcinoma (LA‐HNSCC). Due to higher treatment‐related adverse effects therapy, alternative regimens (non‐standard therapy), namely, lower dose weekly cisplatin, carboplatin/paclitaxel, or cetuximab are considered. There is, however, no consensus on non‐standard regimens. We aimed investigate efficacy safety profile of these Methods This...
Introduction: Sinonasal intestinaltype adenocarcinoma is a rare malignancy originating most commonly from the ethmoid sinuses. Morphologically, this cancer tends to resemble intestinal with immunohistologic staining mirroring what would be expected for gastrointestinal malignancy. Definitive treatment involves surgical resection often followed by radiation. In inoperable or metastatic setting, there limited evidence effective chemotherapeutic regimens. Case Report: A patient unresectable...