A5009905152- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Electrolyte and hormonal disorders
- Hand Gesture Recognition Systems
- Advanced Optimization Algorithms Research
- Growth Hormone and Insulin-like Growth Factors
- Botulinum Toxin and Related Neurological Disorders
- Musculoskeletal pain and rehabilitation
- Renal function and acid-base balance
- Context-Aware Activity Recognition Systems
- Lanthanide and Transition Metal Complexes
- Communication in Education and Healthcare
- Potassium and Related Disorders
- Prenatal Screening and Diagnostics
- Effects of Vibration on Health
- Social and Educational Sciences
- Vitamin C and Antioxidants Research
- Muscle and Compartmental Disorders
- Additive Manufacturing and 3D Printing Technologies
- Genetic Syndromes and Imprinting
- Misinformation and Its Impacts
- Gait Recognition and Analysis
Karolinska Institutet
2019-2024
Centre for Palaeogenetics
2020-2024
Universitat de Barcelona
2024
Karolinska University Hospital
2017-2024
Weatherford College
2024
Stockholm Health Care Services
2023
University Hospital of Basel
2003
Study Design. Trunk sway occurring during clinical stance and gait tasks was compared between a group of subjects with chronic whiplash injury, resulting from an automobile collision, normal collective. Objectives. To examine if population specific trunk patterns for could be identified injury patients. Summary Background Data. Our previous work has established that it is possible to identify deficits vestibular loss (both acute compensated) patients those Parkinson's disease. question...
Acute systemic diseases, such as severe infections, can lead to electrolyte and acid-base alterations. To study the presence of imbalance in COVID-19, we investigated frequency consequences changes patterns over time. We performed a retrospective cohort including 406 patients with COVID-19. Levels electrolytes, base excess, pH, serum osmolality, hematocrit, first 2 weeks hospitalization, were collected daily from laboratory database clinical data patients’ medical records. found that...
There is a need for methods that distinguish Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), which have similar characteristics in the early stages of disease. In this prospective study, we evaluate mapping apparent susceptibility based on weighted imaging (SWI) differential diagnosis. We included 134 patients with PD, 11 PSP, 10 MSA 44 healthy controls. SWI data were processed into maps susceptibility. was increased red nucleus compared...
Abstract Parkinson’s disease (PD) is clinically heterogeneous, which suggests the existence of subtypes; however, there has been no consensus regarding their characteristics. This study included 633 PD individuals across distinct cohorts: unmedicated de novo PD, medicated mild-moderate and a cohort based on diagnostic work-up in clinical practice. Additionally, 233 controls were included. Clustering cortical subcortical gray matter measures was conducted with without adjusting for global...
IntroductionSeparating progressive supranuclear palsy (PSP) from Parkinson's disease (PD) and multiple system atrophy (MSA) is often challenging in early but important for appropriate management. Magnetic resonance imaging (MRI) can aid the diagnostics manual 2D measurements are used. However, new fully automatic brainstem volumetry could potentially be more accurate increase availability of metrics.MethodsClinical 3D T1-weighted MRI were obtained 196 consecutive patients; 29 PSP, 27 MSA,...
Introduction Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T1-/T2-weighted ratio imaging technique, based on standard MRI, reveal differences in neurodegeneration three large cohorts. Methods Three cohorts, with total of 405 participants (269 PD, 44 PSP, 38 MSA, 54 controls), were combined T1/T2-weighted image analyses carried out. A combination automatic segmentation...
Abstract Background: Fluid homeostasis, including electrolyte balance, is dependent on an interaction between the renin-angiotensin-aldosterone system (RAAS) and release of arginine vasopressin from pituitary. An imbalance can lead to both hypo- hypernatremia. We investigated frequency, dynamics severity in critically ill patients with COVID-19. Methods: In this retrospective cohort study 223 confirmed COVID-19, treated at intensive care unit (ICU), were included. Levels electrolytes, base...
Prader-Willi syndrome (PWS) is a rare neurodevelopmental genetic disorder typically characterized by body composition abnormalities, hyperphagia, behavioural challenges, cognitive dysfunction, and hypogonadism. Psychotic illness common, particularly in patients with maternal uniparental disomy (mUPD), antipsychotic medications can result hyperprolactinemia. Information about hyperprolactinemia its potential clinical consequences PWS sparse. Here, we present data from an international,...
<title>Abstract</title> Parkinson’s disease (PD) is clinically heterogeneous, which suggests the existence of subtypes; however, there has been no consensus regarding their characteristics. This study included 633 PD individuals across distinct cohorts: unmedicated de novo PD, medicated mild-moderate and a cohort based on diagnostic work-up in clinical practice. Additionally, 233 controls were included. Clustering cortical subcortical grey matter measures was conducted with without adjusting...
Abstract Background and Purpose Quantitative susceptibility mapping (QSM), neurite orientation dispersion density imaging (NODDI), the g‐ratio have separately shown differences between Parkinson's disease (PD) healthy controls. The has, however, not been studied in PD substantia nigra (SN) putamen. A combination of these methods could also potentially be a complementary biomarker for PD. This study aimed to assess diagnostic performance QSM, NODDI, g‐ratio, combined QSM‐NODDI marker SN...
Abstract Background and Purpose Evidence of brain gadolinium retention has affected gadolinium‐based contrast agent usage. It is, however, unclear to what extent macrocyclic agents are retained whether their in vivo detection may necessitate nonconventional MRI. Magnetization transfer (MT) could prove suitable detect gadolinium‐related signal changes since dechelated ions bind macromolecules. Therefore, this study aimed investigate associations prior administrations with MT T1 abnormalities....