Intensive care for patients with traumatic brain injury (TBI) aims to optimize intracranial pressure (ICP) and cerebral perfusion (CPP). The transformation of ICP CPP time-series data into a dynamic prediction model could aid clinicians make more data-driven treatment decisions. We retrained externally validated machine learning dynamically predict the risk mortality in TBI. Retraining was done 686 62,000 h validation two international cohorts including 638 60,000 data. area under receiver...

Abstract Purpose This study aimed to investigate whether incorporating pre-injury health status, measured by the American Society of Anesthesiologists (ASA) score, improves outcome prediction models for moderate-to-severe traumatic brain injury (msTBI) patients. Methods We conducted a retrospective single-center msTBI patients (2005–2021). The primary was 1-year Glasgow Outcome Scale (GOS, dichotomized as GOS1-3 (unfavorable) vs. 4–5 (favorable)), and secondary 90-day mortality. Logistic...

Preventing intracranial hematoma expansion has been advertised as a possible treatment opportunity in traumatic brain injury (TBI). However, the time course of expansion, and whether affects outcome, remains poorly understood. In light this, aim this study was to use 3D volume rendering determine how hematomas expand over evaluate its impact on outcome.Single-center, population-based, observational cohort adults with moderate-to-severe TBI. Hematoma defined change from baseline computed...

The neuroinflammatory response after traumatic brain injury (TBI) is implicated as a key mediator of secondary in both the acute and chronic periods primary injury. Microglia are innate immune cell central nervous system, responding to with release cytokines chemokines. In this context, we aimed characterize downstream cytokine human induced pluripotent stem (iPSC)-derived microglia when stimulated five separate identified TBI. iPSC-derived were exposed interleukin (IL)-1β, IL-4, IL-6,...

Ticagrelor is associated with a lower risk of ischemic events than clopidogrel. However, it uncertain whether the benefits more intensive anti-ischemic therapy outweigh risks major bleeding in patients who have high (HBR). Therefore, this study compared ticagrelor and clopidogrel myocardial infarction (MI) HBR.This included all enrolled SWEDEHEART registry were discharged dual antiplatelet using or following MI between 2010 2017. High was defined as PRECISE-DAPT score ≥25. Information on...

Abstract Background Moderate-to-severe traumatic brain injury (TBI) has a global mortality rate of about 30%, resulting in acquired life-long disabilities many survivors. To potentially improve outcomes this TBI population, the management secondary injuries, particularly failure cerebrovascular reactivity (assessed via pressure index; PRx, correlation between intracranial (ICP) and mean arterial blood (MAP)), gained interest field. However, derivation PRx requires high-resolution data...

Abstract Background In positron emission tomography (PET) imaging, binding is typically estimated by fitting pharmacokinetic models to the series of measurements radioactivity in target tissue following intravenous injection a radioligand. However, there are multiple different choose from and numerous analytical decisions that must be made when modelling PET data. Therefore, it important analysis tools adapted specific circumstances, analyses documented transparent manner. Kinfitr , written...

Contusion expansion (CE) is a potentially treatable outcome predictor in traumatic brain injury (TBI), and suitable end-point for hemostatic therapy trials. However, there no consensus on the definition of clinically relevant CE, both terms measurement criteria (absolute vs. relative volume increase) cutoff values. In light this, aim this study was to assess predictive abilities different CE definitions outcome. We performed multi-center observational cohort adults with moderate-to-severe...

Abstract Aim We examined the outcomes of using inhaled nitric oxide (iNO) to treat very preterm born (VPT) infants across Europe. Methods This was a sub‐study Screening Improve Health in Very Preterm Infants Europe research. It focused on all between 22 + 0 and 31 6 weeks/days gestation from 2011 2012, 19 regions 11 European countries. studied 7268 admitted neonatal care 5 years later, we followed up 103 who had received iNO treatment. They were compared with 3502 propensity score‐matched...

Studies show conflicting results regarding the prognostic significance of traumatic axonal injuries (TAI) in patients with brain injury (TBI). Therefore, we documented presence TAI several regions, using different magnetic resonance imaging (MRI) sequences, and assessed their association to patient outcomes machine learning. Further, created a novel MRI-based grading system goal improving outcome prediction TBI. We subsequently evaluated performance systems. used genetic algorithm identify...

Abstract Background The aim of this study is to evaluate the impact commonly administered sedatives (Propofol, Alfentanil, Fentanyl, and Midazolam) vasopressor (Dobutamine, Ephedrine, Noradrenaline Vasopressin) agents on cerebrovascular reactivity in moderate/severe TBI patients. Cerebrovascular reactivity, as a surrogate for cerebral autoregulation was assessed using long pressure index (LPRx). We evaluated data two phases, first we minute-by-minute relationships between different dosing...

Introduction Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T1-/T2-weighted ratio imaging technique, based on standard MRI, reveal differences in neurodegeneration three large cohorts. Methods Three cohorts, with total of 405 participants (269 PD, 44 PSP, 38 MSA, 54 controls), were combined T1/T2-weighted image analyses carried out. A combination automatic segmentation...

Abstract In positron emission tomography (PET) imaging, binding is typically estimated by fitting pharmacokinetic models to the series of measurements radioactivity in target tissue following intravenous injection a radioligand. However, there are multiple different choose from and numerous analytical decisions which must be made when modelling PET data. Therefore, full communication all steps involved often not feasible within confines scientific publication. As such, need improve...

Trans-nasal evaporative cooling is an effective method to induce intra-arrest therapeutic hypothermia in out-of-hospital cardiac arrest (OHCA). The use of supraglottic airway devices (SGA) instead endotracheal intubation may enable shorter time intervals cooling. We aimed study the outcomes OHCA patients receiving (ETI) or a SGA during trans-nasal This pre-specified sub-study PRINCESS trial (NCT01400373) that included witnessed randomized resuscitation vs. standard care followed by...

Abstract Background Cardiovascular disease is the primary cause of mortality in patients with type 2 diabetes mellitus (T2DM). Randomized controlled trials (RCT) have shown that Glucagon-like peptide-1 receptor agonists (GLP-1RA) improve cardiovascular outcomes T2DM patients, greater therapeutic benefits observed established atherosclerotic disease. However, effect GLP1-RA therapy on has been inconsistent and RCT not sufficiently powered to examine or their different subgroups patients....

Abstract Background Both sodium–glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1-RA) have been shown to reduce the risk of adverse cardiovascular outcomes in type diabetes mellitus (T2DM) patients with established atherosclerotic disease. Purpose The aim this study was assess comparative effectiveness SGLT2i GLP1-RA myocardial infarction (MI) T2DM. Methods This observational cohort included MI T2DM who were treated or within 180 days hospital...

Abstract Background Potent antiplatelet agents such as ticagrelor are associated with a lower risk of ischemic events than clopidogrel in patients acute coronary syndrome (ACS). However, it is uncertain whether the benefits more intensive anti-ischemic therapy outweigh risks major bleeding individuals who have high (HBR). This study aimed to assess treatment outcomes following dual (DAPT) using either or ACS HBR. Methods All HBR enrolled SWEDEHEART registry were discharged DAPT between 2010...

Prognostication is important in the management of critically ill traumatic brain injury (TBI) patients, as it may guide decisions on treatment intensity. Changes functional connectivity that arise due to TBI have been observed several networks using resting-state magnetic resonance imaging (rs-fMRI). Studies suggest cognitive dysfunction following can, part, be explained by changes connectivity. The overall aim this study was investigate whether easy-to-calculate graph theory-based summaries...

Abstract The authors have requested that this preprint be removed from Research Square.

Abstract Background Hemorrhage progression following traumatic brain injury (TBI) is not fully understood, and preventing it would be a potential therapeutic opportunity in TBI management. The aim of this study was to determine how non-operated hemorrhagic lesions progress TBI, affects outcome. Methods This retrospective observational cohort adult patients (≥ 15 years) with moderate-to-severe TBI. volumes were calculated from computed tomography (CT) scans using semi-automated volumetric...