A5074447742- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Traumatic Brain Injury Research
- S100 Proteins and Annexins
- Trauma and Emergency Care Studies
- Inflammasome and immune disorders
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Radiation Dose and Imaging
- Injury Epidemiology and Prevention
- Neurosurgical Procedures and Complications
- Artificial Intelligence in Healthcare and Education
- Law, Economics, and Judicial Systems
- Medical Malpractice and Liability Issues
- Cervical and Thoracic Myelopathy
- Burn Injury Management and Outcomes
- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Elder Abuse and Neglect
- Advances in Oncology and Radiotherapy
- Pancreatic and Hepatic Oncology Research
- Healthcare Systems and Practices
- Climate Change and Health Impacts
Karolinska Institutet
2021-2025
Brigham and Women's Hospital
2022-2024
Harvard University
2022-2024
Karolinska University Hospital
2023
ORCID
2021
An understanding of global, regional, and national macroeconomic losses caused by stroke is important for allocation clinical research resources. The authors investigated the consequences disease burden in year 2019 173 countries.
Abstract Purpose This study aimed to investigate whether incorporating pre-injury health status, measured by the American Society of Anesthesiologists (ASA) score, improves outcome prediction models for moderate-to-severe traumatic brain injury (msTBI) patients. Methods We conducted a retrospective single-center msTBI patients (2005–2021). The primary was 1-year Glasgow Outcome Scale (GOS, dichotomized as GOS1-3 (unfavorable) vs. 4–5 (favorable)), and secondary 90-day mortality. Logistic...
Neuroinflammation following traumatic brain injury (TBI) has been shown to be associated with secondary development; however, how systemic inflammatory mediators affect this is not fully understood. The aim of study was see inflammation affects markers neuroinflammation, if response had a temporal correlation between compartments and different differ in cytokine composition.TBI patients recruited previous randomised controlled trial studying the effects drug anakinra (Kineret®), human...
Abstract To purpose was to assess and compare the health-related quality of life (HRQoL) risk depression two years after trauma, between patients with without traumatic brain injury (TBI) in a mixed Swedish trauma cohort. In this prospective cohort study, TBI non-TBI included Trauma registry 2019 at level II center Stockholm, Sweden, were contacted admission. HRQoL assessed RAND-36 EQ-5D-3L, Montgomery Åsberg Rating Scale self-report (MADRS-S). Abbreviated Injury Score (AIS) head used grade...
Standardized estimates of global economic losses from burn injuries are lacking. The primary objective this study was to determine the macroeconomic consequences and their geographic distribution.
OBJECTIVE Country-by-country estimates of the macroeconomic disease burden central nervous system (CNS) cancers are important when determining allocation resources related to neuro-oncology. Accordingly, in this study authors investigated losses CNS cancer 173 countries and identified pertinent epidemiological trends. METHODS Data for incidence, mortality, disability-adjusted life years (DALYs) were collected from Global Burden Disease 2019 database. Gross domestic product data combined with...
Repetitive mild traumatic brain injury (rmTBI) is a potentially debilitating condition with long-term sequelae. Animal models are used to study rmTBI in controlled environment, but there currently no established standard battery of behavioral tests used. Primarily, we aimed identify the best combination and timing distinguish injured from uninjured animals studies, secondarily, determine whether combinations independent experiments have better outcome prediction accuracy than individual...
Perinatal asphyxia, resulting in hypoxic-ischaemic encephalopathy (HIE), has been associated with high mortality rates and severe lifelong neurodevelopmental disabilities. Our aim was to study the association between proteomic profile cerebrospinal fluid (CSF) degree of HIE long-term outcomes.We prospectively enrolled 18-term born infants 10-term controls 2000 2004 from Karolinska University Hospital. An antibody suspension bead array FlexMap3D analysis used characterise 178 unique...
Background: Despite the high prevalence and morbidities associated with interpersonal violence (IPV), its estimated costs vary widely, studies primarily focusing on data from high-income countries. This study aims to determine incidence mortality rates attributable IPV quantify global macroeconomic cost of IPV.Methods: The Global Burden Disease reported by Institute Health Metrics Evaluation was collected for years 2009 2019 173 countries, categorized into 21 regions. Incidence were...
Abstract Background: Neuroinflammation following traumatic brain injury (TBI) has been shown to be associated with secondary development, however how systemic inflammatory mediators affect this is not fully understood. The aim of study was see inflammation affects markers neuroinflammation, if response had a temporal correlation between compartments and different differ in cytokine composition.Methods: TBI patients recruited previous randomized controlled trial studying the effects drug...
Survival rate increases for preterm infants, but long-term neurodevelopmental outcome predictors are lacking. Our primary aim was to determine whether a specific proteomic profile in cerebrospinal fluid (CSF) of infants differs from that term and identify novel biomarkers infants.Twenty-seven with median gestational age 27 w + 4 d ten full-term were enrolled prospectively. Protein profiling CSF performed utilizing an antibody suspension bead array. The relative levels 178 unique brain...
Introduction Mild traumatic brain injury (mTBI) is one of the most common reasons for emergency department (ED) visits. A portion patients with mTBI will develop an intracranial lesion that might require medical or surgical intervention. In these patients, swift diagnosis and management paramount. Several guidelines have been developed to help direct head CT scanning, but they lack specificity, do not consider interactions between risk factors provide individualised estimate risk. The aim...
BACKGROUND Neuroinflammation following traumatic brain injury (TBI) has been shown to be associated with secondary development; however, how systemic inflammatory mediators affect this is not fully understood. The aim of study was see inflammation affects markers neuroinflammation, if response had a temporal correlation between compartments and different differ in cytokine composition. METHODS TBI patients recruited previous randomised controlled trial studying the effects drug anakinra...
Abstract Background: Neuroinflammation following traumatic brain injury (TBI) has been shown to be associated with secondary development, however how systemic inflammatory mediators affect this is not fully understood. The aim of study was see inflammation affects markers neuroinflammation, if response had a temporal correlation between compartments and different differ in cytokine composition.Methods: TBI patients recruited previous randomized controlled trial studying the effects drug...