A5066850918- Medical Imaging Techniques and Applications
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Nitric Oxide and Endothelin Effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological disorders and treatments
- Multiple Sclerosis Research Studies
- Cerebrospinal fluid and hydrocephalus
- Neuroscience and Neuropharmacology Research
- CNS Lymphoma Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Viral-associated cancers and disorders
- Genetic Neurodegenerative Diseases
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Cerebrovascular and genetic disorders
- Systemic Sclerosis and Related Diseases
- Electron Spin Resonance Studies
- Inflammatory Bowel Disease
- Dialysis and Renal Disease Management
- Hereditary Neurological Disorders
- Ultrasound and Hyperthermia Applications
- Botulinum Toxin and Related Neurological Disorders
- Monoclonal and Polyclonal Antibodies Research
Karolinska Institutet
2016-2025
Karolinska University Hospital
2015-2024
<h3>BACKGROUND AND PURPOSE:</h3> Quantitative MR imaging techniques are gaining interest as methods of reducing acquisition times while additionally providing robust measurements. This study aimed to implement a synthetic method on new scanner type and compare its diagnostic accuracy volumetry with conventional in patients MS controls. <h3>MATERIALS METHODS:</h3> Twenty 20 healthy controls were enrolled after ethics approval written informed consent. Synthetic was implemented Siemens 3T...
Abstract Background Management of patients with small bowel Crohn’s disease (SBCD) remains challenging due to limited efficacy from current therapeutic options. AZD7798 is a first-in-class monoclonal antibody for CD that depletes CCR9+ lymphocytes, potential targeted treatment SBCD given the critical role CCR9 plays in lymphocyte homing bowel. Monitoring cell depletion and repletion blood straightforward, but difficult accessibility biopsy. Here we use positron emission tomography (PET)...
Virchow-Robin spaces (VRS) have been associated with neurodegeneration and neuroinflammation. However, it remains uncertain to what degree non-dilated or dilated VRS reflect specific features of neuroinflammatory pathology. Thus, we aimed at investigating the clinical relevance as imaging biomarker in multiple sclerosis (MS) correlate their histopathologic signature.In a cohort study comprising 142 MS patients 30 control subjects, assessed association magnetic resonance (MRI) outcomes....
Abstract Aim To describe a rare case of primary refractory Hodgkin lymphoma nodular sclerosis syncytial variant in child and review immunotherapy relapsed/refractory lymphoma. Methods We described the treatment course with classic discussed different options for salvage therapy, an emphasis on immunotherapy. searched PubMed all published clinical trials investigating written English until 31 June, 2023. The reference list each identified paper was additional publications. Results Our patient...
Friedreich ataxia (FRDA) is the most common familial syndrome in Central and Southern Europe but rare Scandinavia. Biallelic mutations SH3 domain tetratricopeptide repeats 2 (SH3TC2) cause Charcot-Marie-Tooth disease type 4C (CMT4C), one of autosomal recessive polyneuropathies associated with early onset, slow progression scoliosis. Beyond nystagmus reported some patients, neither nor cerebellar atrophy has been documented as part CMT4C phenotype. Here we describe a single centre cohort. All...
The underlying pathogenic mechanisms of neurological complications in infants undergoing peritoneal dialysis (PD) are poorly understood. We report on four male treated with PD who developed symptomatic cerebral ischaemia. Blood pressure (BP) levels were low both before the event and at presentation. In two patients, we observed that removal nitrate nitrite by could have impaired nitrate/nitrite--nitrite oxide (NO) pathway, a system generates NO independently synthase. Our observation...
Virchow-Robin spaces (VRS) have been associated with neurodegeneration and neuroinflammation. However, it remains uncertain to what degree non-dilated or dilated VRS reflect specific features of neuroinflammatory pathology. Thus, we aimed at investigating the clinical relevance as imaging biomarker in multiple sclerosis (MS) correlate their histopathologic signature. In a cohort study comprising 205 MS patients (including validation cohort) 30 control subjects, assessed association magnetic...
<title>Abstract</title> Background Parkinson's disease is a neurodegenerative disorder that characterized by degeneration of the dopaminergic system. Dopamine transporter (DAT) positron emission tomography (PET) imaging has emerged as powerful and non-invasive method to quantify function in living brain. The PET radioligand, [<sup>18</sup>F]FE-PE2I, cocaine chemical derivative, shown promising properties for vivo DAT, including high affinity selectivity excellent brain permeability,...
Parkinson's disease is a neurodegenerative disorder that characterized by degeneration of the dopaminergic system. Dopamine transporter (DAT) positron emission tomography (PET) imaging has emerged as powerful and non-invasive method to quantify function in living brain. The PET radioligand, [
Abstract Background and Purpose Evidence of brain gadolinium retention has affected gadolinium‐based contrast agent usage. It is, however, unclear to what extent macrocyclic agents are retained whether their in vivo detection may necessitate nonconventional MRI. Magnetization transfer (MT) could prove suitable detect gadolinium‐related signal changes since dechelated ions bind macromolecules. Therefore, this study aimed investigate associations prior administrations with MT T1 abnormalities....
Virchow-Robin spaces (VRS) have been associated with neurodegeneration and neuroinflammation. However, it remains uncertain to what degree non-dilated or dilated VRS reflect specific features of neuroinflammatory pathology. Thus, we aimed at investigating the clinical relevance as imaging biomarker in multiple sclerosis (MS) correlate their histopathologic signature. In a cohort study comprising 205 MS patients (including validation cohort) 30 control subjects, assessed association magnetic...