<h3>BACKGROUND AND PURPOSE:</h3> Quantitative MR imaging techniques are gaining interest as methods of reducing acquisition times while additionally providing robust measurements. This study aimed to implement a synthetic method on new scanner type and compare its diagnostic accuracy volumetry with conventional in patients MS controls. <h3>MATERIALS METHODS:</h3> Twenty 20 healthy controls were enrolled after ethics approval written informed consent. Synthetic was implemented Siemens 3T...

Abstract This study set out to investigate the behavioral correlates of changes in resting-state functional connectivity before and after performing a 20 minute continuous psychomotor vigilance task (PVT) for patients with chronic post-concussion syndrome. Ten phase mild traumatic brain injury (mTBI) persisting symptoms fatigue ten matched healthy controls participated study. We assessed participants’ levels conducted fMRI sustained PVT. evaluated indices relation subject’s behavior using...

Fatigue is the most frequently reported persistent symptom following a mild traumatic brain injury (mTBI), but explanations for persisting fatigue symptoms in mTBI remain controversial. In this study, we investigated change of cerebral blood flow during performance psychomotor vigilance task (PVT) by using pseudo-continuous arterial spin labeling (PCASL) MRI technique to better understand relationship between fatigability and activity mTBI.Ten patients (mean age: 37.5 ± 11.2 years) with...

Individuals with congenital sensory deprivation usually demonstrate altered brain morphology in areas associated early processing of the absent sense. Here, we aimed to establish whether this also applies individuals born without a sense smell (congenital anosmia) by comparing cerebral between 33 isolated anosmia and matched controls. We detected no morphological alterations primary olfactory (piriform) cortex. However, demonstrated gray matter volume atrophy bilateral sulci, explained...

Morphology of the corpus callosum is a useful biomarker neuronal loss, as different patterns cortical atrophy help to distinguish between dementias such Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). We used sophisticated morphometric analysis in FTLD subtypes including dementia (FTD), semantic (SD), progressive non-fluent aphasia (PNFA), compared them AD patients 27 matched controls. patient subgroups diverged their callosal morphology profiles, with FTD showing...

Abstract Congenital blindness is associated with atypical morphology and functional connectivity within from visual cortical regions; changes that are hypothesized to originate a lifelong absence of input could be regarded as general (re) organization principle sensory cortices. Challenging this the fact individuals congenital anosmia (lifelong olfactory loss) display little no morphological in primary cortex. To determine whether birth essential establish maintain normal processing regions,...

Familial hemiplegic migraine (FHM) is a group of rare familial disorders caused, in most cases, by mutations CACNA1A and ATP1A2 .1 Heterozygous solute carrier family 1 member 3 ( SLC1A3 ), encoding glial glutamate transporter, are associated with episodic ataxia type 6 (EA6).2–5 In addition to (EA), alternating hemiplegia have been reported twice patients EA6.2,4 Mutations very rare; screenings cohorts EA yielded either negative results3,6–8 or variants unclear significance.e-1--e-3 Herein,...

Epidemiological studies show an association between masticatory function and cognitive impairment. This has further strengthened the notion that tooth loss impaired may be risk factors for dementia decline. Animal experiments have indicated a causal relationship several possible mechanisms been discussed. evidence is, however, lacking in humans. Therefore, current interventional study, we aim to investigate effect of rehabilitation on cognition older adults.

Introduction Chronic pain (CP) is one of the most frequently presenting conditions in health care and many patients with CP report mental fatigue a decline cognitive functioning. However, underlying mechanisms are still unknown. Methods analysis This study protocol describes cross-sectional aimed at investigating presence self-rated fatigue, objectively measured fatigability executive functions their relation to other functions, inflammatory biomarkers brain connectivity CP. We will control...

Abstract Background A proportion of patients with mild traumatic brain injury (mTBI) suffer long-term consequences, and the reasons behind this are still poorly understood. One factor that may affect outcomes is cognitive reserve, which brain's ability to maintain function despite injury. It often assessed through educational level or premorbid IQ tests. This study aimed explore whether there were differences in post-concussion symptoms symptom resolution between mTBI minor orthopedic...

To perform a comprehensive characterization of cohort patients with chorea-acanthocytosis (ChAc) in Sweden.Clinical assessments, targeted genetic studies, neuroimaging MRI, [18F]-fluorodeoxyglucose (FDG) PET, and dopamine transporter 123I FP-CIT (DaTscan) SPECT. One patient underwent magnetic resonance spectroscopy (MRS).Four living Sweden but different ethnical backgrounds were included. Their clinical features variable. Biallelic VPS13A mutations confirmed all patients, including 3 novel...

Lifelong auditory and visual sensory deprivation have been demonstrated to alter both perceptual acuity the neural processing of remaining senses. Recently, it was that individuals with anosmia, i.e. complete olfactory deprivation, displayed enhanced multisensory integration performance. Whether this ability is due a reorganization regions focus on cross-modal information or whether within not known. To dissociate these two outcomes, we investigated dynamic audio-visual stimuli in congenital...

<h3>BACKGROUND AND PURPOSE:</h3> Diffuse gliomas, a heterogeneous group of primary brain tumors, have traditionally been stratified by histology, but recent insights into their molecular features, especially the <i>IDH</i> mutation status, fundamentally changed classification and prognosis. Current diagnostic methods, still predominantly relying on invasive biopsy, necessitate exploration noninvasive imaging alternatives for glioma characterization. <h3>MATERIALS METHODS:</h3> In this...

ABSTRACT Individuals with congenital sensory loss usually demonstrate altered brain morphology in areas associated early processing of the lost sense. Here, we aimed to establish whether this also applies individuals born without a sense smell (congenital anosmia) by comparing cortical between 33 isolated anosmia and matched controls. We detected no structural alterations primary olfactory (piriform) cortex. However, demonstrated gray matter volume atrophy bilateral sulci, explained...

Masticatory parameters, such as reduced number of teeth and posterior contacts, have been shown to be associated with cognitive status. The underlying mechanisms that affect these associations, are however, not well understood.The study aims investigate the association between masticatory dysfunction cognition explore mediating effect brain structure.In this cross-sectional study, 45 older adults subjective (mean age 72.3 ± 4.0 years) were included. Mini-Mental State Examination score <25,...

ABSTRACT Congenital blindness is associated with atypical morphology, and functional connectivity within from, visual cortical regions; changes that are hypothesized to originate from a life-long absence of input could be regarded as general (re)organization principle sensory cortices. Challenging this the fact individuals congenital anosmia (life-long olfactory loss) display little no morphological in primary cortex. To determine whether birth essential establish maintain normal processing...