A5038759459- Cancer Genomics and Diagnostics
- Renal and related cancers
- Cutaneous Melanoma Detection and Management
- Genetic and rare skin diseases.
- Genetic and Kidney Cyst Diseases
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
- Urologic and reproductive health conditions
- Sarcoma Diagnosis and Treatment
- Lipid metabolism and disorders
- Vascular Malformations and Hemangiomas
- Oral Health Pathology and Treatment
- Ocular Oncology and Treatments
- Renal cell carcinoma treatment
- Hedgehog Signaling Pathway Studies
- Nonmelanoma Skin Cancer Studies
- Histiocytic Disorders and Treatments
- Cancer and Skin Lesions
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Tumors and Oncological Cases
Stanford University
2015-2020
Stanford Medicine
2015-2020
Birmingham Children's Hospital
2007
Recent advances in the immunotherapeutic treatment of cancer have led to development multiple new directed therapies including monoclonal antibodies that block immune checkpoint T-cell receptor programmed death 1 (PD-1) and PD-1 ligand, ligand (PD-L1). Various immune-related toxicities been associated with these drugs including, most commonly, skin rashes.Five cases lichenoid dermatitis, one case mucositis lichen sclerosus, anti-PD-L1 anti-PD1 therapy were compared three biopsies...
Background Desmoplastic small round cell tumor (DSRCT) is a rare malignant that generally manifests as abdominal paraserosal masses and affects mainly male adolescents young adults. When presenting within visceral organs, the diagnosis of DSRCT poses significant difficulties. Methodology Four primary renal in children diagnosed during 3-year period are basis this report. The medical records pathologic material were reviewed, including immunohistochemical, ultrastructural,...
Response to programmed death 1 (PD-1) inhibitors has been associated with ligand (PD-L1) expression levels in several cancers, but PD-L1 and its clinical significance basal cell carcinoma (BCC) are unknown date.To assess treatment-naive treated BCCs.This investigation was a cross-sectional study at single academic tertiary referral center. Immunohistochemical staining on formalin-fixed BCCs from dermatology clinic were examined masked fashion by dermatopathologist dermatologist. The dates...
Our understanding of melanoma precursors and progression to has developed as a result advances in the field molecular diagnostics. We now better understand potential for genetic heterogeneity within single lesion. Combined tumors can pose diagnostic challenge when deciding line between benign malignant, which turn direct implications patient management. Primary cilia (PC) are ubiquitous sensory organelles that have essential functions cellular proliferation, differentiation, development. The...
Non-alcoholic fatty liver disease (NAFLD) is now one of the most common reasons for referral chronic in children and young people developed world.1 As adults, NAFLD associated with obesity, insulin resistance, type 2 diabetes mellitus but may also be present several inherited disorders such as Alstrom syndrome Bardet-Biedl syndrome.2 Various studies have suggested rates 2.6-9.8%,3 rising to 10-77% among obese children.1 Childhood has both similarities differences from adult and, NAFLD,...
Primary cilia are ubiquitously present in cell surface organelles with essential functions cellular proliferation, differentiation and development. We have previously shown that melanoma situ, invasive metastatic nearly completely lost, whereas benign nevi ciliated. Dysplastic (DN) a wide range of histopathologic features from mild (low-grade) to severe (high-grade) cytologic atypia represent key clinical marker for melanomagenesis. sought identify whether retained these melanocytic lesions...
Abstract Background A eukaryotic cell's primary cilium (PC) is critical for cell signaling, migration and homeostasis. Primary dysfunction has been demonstrated in several malignancies, but whether cilia loss occurs acral melanoma remained unknown. To address this, we examined the ciliation index (% melanocytes containing a PC) of patient‐derived, biopsy‐proven compared these to benign nevi. Methods We generated pilot initiative study that included six melanomas seven nevi derived from foot....
<h3>Abstract</h3> <h3>Introduction</h3> A lot of research is available about clear cell renal carcinomas (ccRCC). But there are lesser known facts other subtypes malignancies. With advances in immunohistochemical and cytogenetic techniques, new variants tumors being increasingly reported. The treatment prognosis such rare malignancies still an enigma. We performed this study to analyze the incidence, clinico-pathological features, surgical treatment, survival non-clear RCC at our...