A5005467802- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biosimilars and Bioanalytical Methods
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- Head and Neck Cancer Studies
- Cancer Risks and Factors
- Gallbladder and Bile Duct Disorders
- RNA modifications and cancer
- Cervical Cancer and HPV Research
- Multiple and Secondary Primary Cancers
- COVID-19 Clinical Research Studies
- Molecular Biology Techniques and Applications
- Phytase and its Applications
- Long-Term Effects of COVID-19
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Helicobacter pylori-related gastroenterology studies
- COVID-19 and Mental Health
- Esophageal Cancer Research and Treatment
- Global Cancer Incidence and Screening
- Oral Health Pathology and Treatment
- Occupational and environmental lung diseases
- Neonatal Respiratory Health Research
- SARS-CoV-2 and COVID-19 Research
Advanced Centre for Treatment, Research and Education in Cancer
2016-2024
Tata Memorial Hospital
2015-2024
Homi Bhabha National Institute
2018-2024
Bhabha Atomic Research Centre
2010-2019
Maharashtra Institute of Medical Science and Research
2014
Maharashtra Institute of Medical Education and Research
2014
Abstract Stomach cancer is the one of leading cause in southern region India. Its incidence decreasing worldwide yet on global scale stomach remains most common causes death. Etiology gastric includes Helicobacter pylori infection, diet and lifestyle, tobacco, alcohol genetic susceptibility. In this review, we tried to find contribution Indian scientist understanding descriptive observational epidemiology cancer. PubMed was used as a search platform using key words such "stomach cancer,...
Current evidence suggests that the relationship between obesity and breast cancer (BC) risk may vary ethnic groups.
Abstract The risk factors for breast cancer have been defined in several studies but there is deficient data specific subtypes. We report here the pathological characteristics of a cohort and patients with triple-negative disease. In this case–control study, prospective was evaluated demographic, reproductive, obesity-related other using validated questionnaire. Tumors were characterized routine immunohistochemical markers basal-like cancer. Patients (TNBC) constituted cases those non-TNBC...
Genome-wide association studies (GWAS) of oral cancers (OC) to date have focused predominantly on European Ancestry (EA) populations. India faces an excess burden OC, but the most common site occurrence is cancer buccal mucosa, which relatively rare in EA We conducted a GWAS mucosa (BMC) comprising 2,160 BMC cases and 2,325 controls from different geographical locations India. Single-SNP tests detected one novel locus (6q27) signal within known OC risk 5p13.33, at genome-wide significance...
Objective: To study the effectiveness of locally assembled low-cost version for continuous positive airway pressure (CPAP) delivery.
The current study aimed to investigate the role of cooking with mustard oil and other dietary factors in relation gallbladder cancer (GBC) high‐ low‐incidence regions India. A case–control was conducted including 1,170 histologically confirmed cases 2,525 group‐matched visitor controls from largest hospital Dietary data were collected through a food frequency questionnaire. For consumption, we enquired about monthly consumption 11 different types per family number individuals usually sharing...
Objective To understand the outcome of hospitalised patients from Mumbai City, which had highest number COVID-19 cases in India. Design Observational study with follow-up. Setting Data extraction medical records admitted to Nair Hospital & TN Medical College, Mumbai, Participants 689 were hospital 26 March 2020 11 May 2020. Primary and secondary measures In-hospital mortality; joint effect comorbidity age on risk dying. Results A total (median 44 years) RT-PCR-confirmed included study....
Abstract Background: Gallbladder cancer (GBC), a common surrounding the Gangetic belt of India, accounts for 80%–90% biliary tract cancers. GBC incidence shows striking geographical variation in India. Materials and Methods: We used data from National Cancer Registry Programme year 2001–2014 to study time trends high- low-risk regions Annual percentage change (APC) age-adjusted rates was computed by log-linear regression model. Results: Among females, statistically significant increase trend...
Past history of gallstones is associated with increased risk gallbladder cancer in observational studies. We conducted complementary and Mendelian randomization (MR) analyses to determine whether causally related development an Indian population.
Abstract On a global scale, gallbladder cancer is relatively rare with striking variability in incidence across countries and world regions. We examined recent geographic variations worldwide based on national estimates for the year 2022 from GLOBOCAN database 185 alongside recorded data most volume of Cancer Incidence Five Continents. In 2022, 122,491 new cases 89,055 deaths were estimated to occur worldwide, which 64.5% 64.7% respectively among females. The highest reported rates (ASR per...
Abstract To date, no studies have investigated the association of GWAS-identified SNPs with BC risk in Indian population. We 30 previously reported and replicated susceptibility 1,204 cases 1,212 controls from a hospital based case-control study conducted at Tata Memorial Hospital, Mumbai. As measure total burden, polygenic score (PRS) for each individual was defined by weighted sum genotypes 21 independent weights derived published estimates odds-ratios. Logistic regression models were used...
Tobacco products are used in vary many forms India. Although the risk of tobacco uses developing head and neck cancer (HNC) is known, by exclusive use different on HNC its subtypes poorly understood. A case-control study was conducted at a tertiary hospital, which receives cases from geographical regions India with types products. The included 824 oral cavity (OC), 149 oropharynx (OPX) 104 hypopharyngeal (HPX) 81 larynx (LX) 1206 visitor controls. Information 11 exposure to secondhand smoke...
Why was the cohort set up?The Indian Study of Healthy Ageing (ISHA) is a blood-based prospective study approximately 220 000 individuals aged 30-69, recruited between 2015 and 2020 from towns villages around Barshi, Solapur district, Maharashtra state, India (Supplementary Figure S1, available as Supplementary data at IJE online).The established with aim testing hypotheses relating to lifestyle, diet, obesity related factors, identifying potential genetic determinants cancer other chronic...
<ns4:p><ns4:bold>Background:</ns4:bold>Limited infrastructure is available to collect, store and transport venous blood in field epidemiological studies. Dried spot (DBS) a robust potential alternative sample source for studies & bio banking. A stable of genomic DNA (gDNA) required long term storage bank its downstream applications. Our objective optimize the methods gDNA extraction from stored DBS with aim revealing utility large scale </ns4:p><ns4:p><ns4:bold>Methods:</ns4:bold>The...
Background: Limited infrastructure is available to collect, store and transport venous blood in field epidemiological studies. Dried spot (DBS) a robust potential alternative sample source for studies & bio banking. A stable of genomic DNA (gDNA) required long term storage bank its downstream applications. Our objective optimize the methods gDNA extraction from stored DBS with aim revealing utility large scale Methods: The purpose this study was extract maximum amount on Whatman 903 protein...
Optically stimulated luminescence (OSL) intensity versus dose response of indigenously developed LiMgPO4:Tb,B (LMP) disks is linear in the range 1 mGy–1 kGy. Currently, no other synthetic OSL phosphor available, which covers such a large range. In order to assess feasibility using low-dose food irradiation dosimetry (up kGy), dosimetric characterization LMP-based dosimeter was carried out under both, gamma and electron beam irradiation. The doses estimated by LMP routine dosimeters match...
Although a subset of head and neck cancers (HNC) has been associated worldwide with mucosal high-risk human papillomaviruses (HPV), information on the prevalence HPV-positive HNC in India is limited. In this study, we examined 21 subtypes HPV sub-sites (
In India, as elsewhere, the incidence of gall-bladder cancer (GBC) is substantially higher in women than men. Yet, relevance reproductive factors to GBC remains poorly understood.
Introduction: The aim was to determine the prevalence and predictors of depression among less symptomatic COVID-19 patients. Methods: A questionnaire-based assessment conducted asymptomatic or mildly patients when admitted in a facility (T1) after 6 months (T2). Interviews were using Patient Health Questionnaire-9 instrument. Socio-demographic details length stay recorded. Changes scores between two-time points T1 T2 compared. Factors predicting determined Chi-square Mann–Whitney U test...
Purpose: Identifying infectious pathogens by collecting intravenous blood (IVB) is a well-established procedure, however, the collection of IVB in field epidemiological study challenging. The dried spot (DBS) as an alternative to has been introduced, although, there limited demonstrate utility DBS stored at various storage conditions and transported different periods. This observational study, which evaluates effectiveness studies identify pathogens. Materials Methods: A total 264 paired...