A5002721039- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Delphi Technique in Research
- Infectious Aortic and Vascular Conditions
- Cardiovascular Function and Risk Factors
- Pregnancy and preeclampsia studies
- Iron Metabolism and Disorders
- Cancer, Lipids, and Metabolism
- Renal and Vascular Pathologies
- Hemodynamic Monitoring and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle and Compartmental Disorders
- Lymphadenopathy Diagnosis and Analysis
- Trace Elements in Health
- Healthcare cost, quality, practices
- Reconstructive Surgery and Microvascular Techniques
- Salivary Gland Tumors Diagnosis and Treatment
University of the Witwatersrand
2016-2025
Johannesburg Hospital
2020-2025
University of Oxford
2017-2023
Nuffield Orthopaedic Centre
2017-2023
John Radcliffe Hospital
2018-2023
Oxford University Hospitals NHS Trust
2017
Abstract The immune system is integral to cardiovascular health and disease. Targeting inflammation ameliorates adverse outcomes. Atherosclerosis, a major underlying cause of disease, conceptualized as lipid-driven in which macrophages play nonredundant role. However, evidence emerging so far from single-cell atlases suggests dichotomy between lipid-associated inflammatory macrophage states. Here, we present an inclusive reference atlas human intraplaque cell communities. Combining RNA...
Accurate prediction of abdominal aortic aneurysm (AAA) growth in an individual can allow personalised stratification surveillance intervals and better inform the timing for surgery. The authors recently described novel significant association between flow mediated dilatation (FMD) future AAA growth. feasibility predicting was explored patients using a set benchmark machine learning techniques.The Oxford Abdominal Aortic Aneurysm Study (OxAAA) prospectively recruited undergoing routine NHS...
Biomarker(s) for prediction of the future progression rate abdominal aortic aneurysms (AAA) may be useful to stratify management individual patients. AAAs are associated with features systemic inflammation and endothelial dysfunction. Flow mediated dilatation (FMD) brachial artery is a recognised non-invasive measurement function. We hypothesised that FMD potential biomarker AAA reflects temporal changes function during progression.
IntroductionType 2 endoleaks (T2Es) after endovascular repair (EVAR) of abdominal aortic aneurysm (AAA) can lead to sac expansion or failure regression, and often present as a management dilemma. The intraluminal thrombus (ILT) may influence the likelihood EVAR be characterized using routine preoperative imaging. We examined relationship between spatial morphology ILT incidence postoperative T2E.MethodsAll patients who underwent at John Radcliffe Hospital (Oxford, UK) were prospectively...
Hepcidin is a liver-derived hormone that controls systemic iron homeostasis, by inhibiting the exporter ferroportin in gut and spleen, respective sites of absorption recycling. also expressed ectopically context cardiovascular disease. However, precise role ectopic hepcidin underlying pathophysiology unknown. In patients with abdominal aortic aneurysm (AAA), markedly induced smooth muscle cells (SMCs) wall inversely correlated expression LCN2 (lipocalin-2), protein implicated AAA pathology....
Objective: Discovery of novel biomarkers for AAA growth prediction. Background: Novel biomarker is a recognized priority in research. Our prior work implicated intraluminal thrombus (ILT) AAAs to be potential source systemic mediators during progression. Here we applied mass spectrometry proteomics pipeline discover Methods: Patients were prospectively recruited. Plasma samples collected at baseline (n = 62). was recorded 12 months. In Experiment 1, plasma from the fastest and slowest...
Objective: The age at which arteriosclerosis begins to contribute events is uncertain. We determined, across the adult lifespan, extent arteriosclerosis-related changes in arterial function occur those with precipitous (stroke and critical limb ischemia). Approaches Results: In 1082 black South Africans (356 either ischemia [n=238] or stroke [n=118; 35.4% premature], 726 age, sex, ethnicity-matched randomly selected controls), was evaluated from applanation tonometry velocity diameter...
The epidemiology of abdominal aortic aneurysm (AAA) is changing. Outcomes for surgery have improved. Biomarkers AAA progression are emerging. We recently reported the opinions international vascular colleagues regarding research and management AAAs. This study aimed to ascertain a real-world patients' opinion same questions.We administered survey patients with first ascertained their views on priority topics in AAA. Using contemporary epidemiologic surgical outcome data. asked preferences...
The ability of carotid intima–media thickness (IMT) to predict risk beyond plaque is controversial. In 952 participants (critical limb ischemia [CLI] or stroke, n = 473; community, 479), we assessed whether relationships with events for IMT complement the impact in young patients depending on extent thrombotic versus atherosclerotic disease. occlusion was determined 54 CLI requiring amputations. Thrombotic associated younger age ( P < .0001) and less .02). Independent relations between...
The epidemiology of abdominal aortic aneurysm (AAA) is changing. Outcomes for surgery have improved. However, the accepted guideline management AAAs has remained unchanged over last 2 decades. We aimed to gain insight into patients' experience while they are managed under traditional clinical pathway.With help a patient focus group, we designed survey assess perception disease and their during different stages AAA care pathway (surveillance, perioperative care, postoperative follow-up). An...
BackgroundThe iliofemoropopliteal artery significantly changes path length during normal hip and knee flexion. Prosthetic bypass grafts, such as polytetrafluoroethylene (PTFE) are relatively stiff thus can subject graft anastomoses to high tension when the increases. The aim of this study was examine influence redundancy twist on biomechanical properties PTFE grafts.MethodsUnreinforced ring-reinforced grafts were loaded in an axial mechanical testing machine measure tensile compressive...
We aimed to determine whether the impact of aortic stiffness on atherosclerotic or small vessel end organ damage beyond brachial blood pressure depends in-part stiffness-induced increases in central arterial pressures produced by an enhanced resistance flow (characteristic impedance, Zc).We studied 1021 participants, 287 with stroke critical limb ischaemia, and 734 from a community sample measures. Central haemodynamics were determined (SphygmoCor) velocity diameter assessments outflow tract...
As part of the Oxford Abdominal Aortic Aneurysm (OxAAA) Study, we conducted an international survey vascular surgery professionals. One aspect is as published in International Journal Cardiology: "International Opinion on Priorities Research for Small Aneurysms and Potential Path to Impact Clinical Management". This Data-in-Brief article contains a detailed method conduct this additional original data. In survey, also provided colleagues with contemporary epidemiologic surgical outcome was...