A5045339263- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced X-ray and CT Imaging
- Venous Thromboembolism Diagnosis and Management
- Renal and Vascular Pathologies
- Diagnosis and Treatment of Venous Diseases
- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Peripheral Artery Disease Management
- Iron Metabolism and Disorders
- Pregnancy and preeclampsia studies
- MRI in cancer diagnosis
- Abdominal vascular conditions and treatments
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Infectious Aortic and Vascular Conditions
- Patient-Provider Communication in Healthcare
- Diversity and Career in Medicine
- Patient Dignity and Privacy
- Innovations in Medical Education
- Dental Education, Practice, Research
- Vascular anomalies and interventions
Stony Brook Medicine
2016-2025
Stony Brook University Hospital
2015-2024
Icahn School of Medicine at Mount Sinai
2024
John Radcliffe Hospital
2020-2023
University of Oxford
2019-2023
Oxford University Hospitals NHS Trust
2021
Science Oxford
2020
Nuffield Orthopaedic Centre
2020
Stony Brook University
2017
Accurate prediction of abdominal aortic aneurysm (AAA) growth in an individual can allow personalised stratification surveillance intervals and better inform the timing for surgery. The authors recently described novel significant association between flow mediated dilatation (FMD) future AAA growth. feasibility predicting was explored patients using a set benchmark machine learning techniques.The Oxford Abdominal Aortic Aneurysm Study (OxAAA) prospectively recruited undergoing routine NHS...
Background: Intravenous contrast agents are routinely used in CT imaging to enable the visualization of intravascular pathology, such as with abdominal aortic aneurysms. However, injection is contraindicated patients iodine allergy and associated renal complications. Objectives: In this study, we investigate if raw data acquired from a noncontrast image contains sufficient information differentiate blood other soft tissue components. A deep learning pipeline underpinned by generative...
IntroductionType 2 endoleaks (T2Es) after endovascular repair (EVAR) of abdominal aortic aneurysm (AAA) can lead to sac expansion or failure regression, and often present as a management dilemma. The intraluminal thrombus (ILT) may influence the likelihood EVAR be characterized using routine preoperative imaging. We examined relationship between spatial morphology ILT incidence postoperative T2E.MethodsAll patients who underwent at John Radcliffe Hospital (Oxford, UK) were prospectively...
Objective: We investigated the utility of geometric features for future AAA growth prediction. Background: Novel methods prediction are recognized as a research priority. Geometric feature have been used to predict cerebral aneurysm rupture, but not examined predictor growth. Methods: Computerized tomography (CT) scans from patients with infra-renal AAAs were analyzed. Aortic volumes segmented using an automated pipeline extract diameter (APD), undulation index (UI), and radius curvature...
Abstract Introduction Contrast-enhanced computerised tomographic (CT) angiograms are widely used in cardiovascular imaging to obtain a non-invasive view of arterial structures. In aortic aneurysmal disease (AAA), CT required prior surgical intervention differentiate between blood and the intra-luminal thrombus, which is present 95% cases. However, contrast agents associated with complications at injection site as well renal toxicity leading contrast-induced nephropathy (CIN) failure. Purpose...
Background: Existing methods to reconstruct vascular structures from a computerized tomography (CT) angiogram rely on contrast injection enhance the radio-density within vessel lumen. However, pathological changes in vasculature may be present that prevent accurate reconstruction. In aortic aneurysmal disease, thrombus adherent wall expanding sac is >90% of cases. These deformations automatic extraction vital clinical information by existing image reconstruction methods. Aim: this study,...
Hepcidin is a liver-derived hormone that controls systemic iron homeostasis, by inhibiting the exporter ferroportin in gut and spleen, respective sites of absorption recycling. also expressed ectopically context cardiovascular disease. However, precise role ectopic hepcidin underlying pathophysiology unknown. In patients with abdominal aortic aneurysm (AAA), markedly induced smooth muscle cells (SMCs) wall inversely correlated expression LCN2 (lipocalin-2), protein implicated AAA pathology....
Objective: Discovery of novel biomarkers for AAA growth prediction. Background: Novel biomarker is a recognized priority in research. Our prior work implicated intraluminal thrombus (ILT) AAAs to be potential source systemic mediators during progression. Here we applied mass spectrometry proteomics pipeline discover Methods: Patients were prospectively recruited. Plasma samples collected at baseline (n = 62). was recorded 12 months. In Experiment 1, plasma from the fastest and slowest...
Abstract Objectives Positron emission tomography (PET) imaging is a costly tracer-based modality used to visualise abnormal metabolic activity for the management of malignancies. The objective this study demonstrate that non-contrast CTs alone can be differentiate regions with different Fluorodeoxyglucose (FDG) uptake and simulate PET images guide clinical management. Methods Paired FDG-PET CT ( n = 298 patients) diagnosed head neck squamous cell carcinoma (HNSCC) were obtained from cancer...
Abstract Background Existing methods to reconstruct vascular structures from a computed tomography (CT) angiogram rely on injection of intravenous contrast enhance the radio-density within vessel lumen. Pathological changes present blood lumen, wall or combination both prevent accurate 3D reconstruction. In example aortic aneurysmal (AAA) disease, clot thrombus adherent expanding sac is in 95% cases. These deformations automatic extraction vital clinically relevant information by current...
Contrast-enhanced computed tomography angiograms (CTAs) are widely used in cardiovascular imaging to obtain a non-invasive view of arterial structures. However, contrast agents associated with complications at the injection site as well renal toxicity leading contrast-induced nephropathy (CIN) and failure. We hypothesised that raw data acquired from non-contrast CT contains sufficient information differentiate blood other soft tissue components. utilised deep learning methods define...
Background: Abdominal aortic aneurysms (AAA) are pathological dilatations of the aorta which can result in rupture and mortality. Novel methods predicting AAA growth is a recognised priority research. Patient with AAAs have increased risk cardiovascular morbidity. We previously observed accelerated systemic endothelial dysfunction (measured by brachial artery FMD) patients FMD correlates future growth. Further, reversed repair. contain intra-luminal thrombus (ILT). Since ILT either removed...
Existing methods to reconstruct vascular structures from a computed tomography (CT) angiogram rely on injection of intravenous contrast enhance the radio-density within vessel lumen. However, pathological changes can be present in blood lumen, wall or combination both that prevent accurate reconstruction. In example aortic aneurysmal disease, clot thrombus adherent expanding sac is 70-80% cases. These deformations automatic extraction vital clinically relevant information by current methods....