A5027667544- Gut microbiota and health
- Folate and B Vitamins Research
- Barrier Structure and Function Studies
- Cancer-related Molecular Pathways
- Vitamin D Research Studies
- Hemoglobinopathies and Related Disorders
- Healthcare Systems and Reforms
- Iron Metabolism and Disorders
- Clinical Nutrition and Gastroenterology
- Cell death mechanisms and regulation
- Metastasis and carcinoma case studies
- Escherichia coli research studies
- Vitamin C and Antioxidants Research
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Teratomas and Epidermoid Cysts
- Transplantation: Methods and Outcomes
- Multiple Myeloma Research and Treatments
- Global Maternal and Child Health
- Adipokines, Inflammation, and Metabolic Diseases
- Immune cells in cancer
- Data-Driven Disease Surveillance
- Metabolism, Diabetes, and Cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Endoplasmic Reticulum Stress and Disease
Jamia Hamdard
2022
Institute of Medical Sciences
2018-2022
Maulana Azad Medical College
2009-2021
University of Delhi
2019-2021
University of Calgary
2016-2018
The short-chain fatty acid butyrate is produced by fermentation of dietary fiber the intestinal microbiota; primary energy source colonocytes and has immunomodulatory effects. Having shown that macrophages differentiated with IL-4 [M(IL-4)s] can suppress colitis, we hypothesized would reinforce an M(IL-4) phenotype. Here, show in presence M(IL-4)s display reduced expression their hallmark markers Arg1 Ym1 significantly suppressed LPS-induced nitric oxide, IL-12p40, IL-10 production. Butyrate...
The gut microbiome contributes to inflammatory bowel disease (IBD), in which bacteria can be present within the epithelium. Epithelial barrier function is decreased IBD, and dysfunctional epithelial mitochondria endoplasmic reticulum (ER) stress have been individually associated with IBD. We therefore hypothesized that combination of ER mitochondrial stresses significantly disrupt function. Here, we treated human colonic biopsies, colonoids, cells an uncoupler oxidative phosphorylation,...
Irregular mitochondria structure and reduced ATP in some patients with IBD suggest that metabolic stress contributes to disease. Loss-of-function mutation the nucleotide-binding oligomerization domain (NOD)-2 gene is a major susceptibility trait for IBD. Hence, we assessed if loss of NOD2 further impairs epithelial barrier function instigated by disruption mitochondrial synthesis via hydrogen ionophore dinitrophenol (DNP). protein (virtually undetectable epithelia under basal conditions) was...
Vitamin D deficiency and vitamin receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role its polymorphisms in ovarian cancer has not been clearly defined.To study levels serum occurrence polymorphism (FokI) cases cancer.FokI genotyping was done by PCR-RFLP technique were estimated chemiluminescence immunoassay.Serum significantly (p < 0.03) lower as compared controls. The homozygous (TT) heterozygous (CT) genotype predispose development Indian...
To compare and study the dipeptidy1 peptidase-4 (DPP-4) inhibitors in combination with metformin against established therapies.This 16-week was designed to sitagliptin versus pioglitazone as add-on therapy patients of type 2 diabetes mellitus inadequately controlled alone. Fifty-two were randomized into two groups receive either 100 mg (group 1) or 30 2) addition metformin. The primary efficacy end point change HbA1c. Secondary points included fasting plasma glucose (FPG), body weight lipid...
Introduction: A multifactorial aetiology of coronary artery disease (CAD) has been established in the recent past.Extensive research is now underway to understand mechanisms responsible for plaque vulnerability.The identification a novel biomarker that will help assessment status urgently needed purpose patient stratification and prognostication.The aim present study was evaluate leptin, pregnancy-associated plasma protein (PAPP-A) C-reactive (CRP) levels patients with acute syndrome assess...
Multiple myeloma is characterized by plasma cell infiltration of the bone marrow and presence a monoclonal protein in and/or urine. with biclonal gammopathy rare (1%). In this report, we describe case multiple having two M bands on serum electrophoresis. He had elevated IgG IgA levels. Ig G Kappa Lambda light chains respectively were detected immunofixation. It very immunofixation pattern seen any gammopathy. The patient presented vertebral pelvic involvement neurosensory both lower limbs....
A well-built, national-level surveillance system for communicable and non-communicable diseases is the hour of need any country. As part International Health Regulation (IHR) core capacity building to strengthen public health system, India needs a comprehensive information monitor emerging threats, disasters mass events. has identified such during mid-90s launched WHO-supported National Surveillance Project Communicable Diseases (NSPCD) in 1997–98 selected districts. Subsequently, based on...
IntroductionHereditary hemochromatosis (HH) is an autosomal recessive genetic disease of iron regulation associated with overload and failure several organs. Whether mutations in the (HFE) gene increase cardiovascular risk still undetermined. In present study, we aimed to analyse influence HFE C282Y mutation on development coronary artery (CAD) north Indian population.Materials methodThe study included hundred CAD patients who showed presence greater than 50% luminal stenosis at least one...
Pro-apoptotic Bcl-2 protein BAX is an important member of mitochondrial dependent apoptosis regulation and ultimately plays a pivotal role in malignancies. A promoter G(-248)A polymorphism the TP53 binding region results differential capacity there by regulating its expression, which has been found to be associated with different clinical outcomes various Presently we aimed analyze possible impact on risk other features non-small cell lung cancer Indian population. The was analyzed blood...
Iron is an essential element and its correct balance necessary for good health normal cellular functioning [1]. Hepcidin the iron-regulatory hormone of hepatic origin. It a defensin-like low-molecular-weight peptide that plays important role in iron metabolism. receptor ferroportin play most controlling dietary absorption tissue distribution iron. Recently discovered hepcidin molecule has been recognized as main behind pathogenesis anemia chronic disease.
Background Prevailing experimental and epidemiological evidence supports the role of circulating endogenous sex steroid hormones in pathogenesis ovarian carcinogenesis by dysregulation cell differentiation, proliferation, apoptosis but is scarce inconclusive. Objectives This article evaluates levels gonadotropins (follicle-stimulating hormone [FSH], luteinizing [LH]) androgens (testosterone, dehydroepiandrosterone-sulfate [DHEA-S]) for risk epithelial cancer a case-control approach using...
Objectives: Coronary Artery Disease (CAD) is the leading cause of deaths worldwide. Both genetic and environment factors are responsible for CAD. However, these nongentic interaction between them need to be further clarified. Methylene tetrahydrofolate reductase (MTHFR) enzyme converts 5,10-methylene 5-methyltetrahydrofolate finaly homocysteine methionine. Individuals having C677T substitution have a reduced activity hence higher level but lower folate levels than individuals without this...
Background: India was the first country in world to have launched a National Programme for Family Planning.Methods: A cross-sectional descriptive study carried out Vaccination unit of rural field practice area Shri Ram Murti Smarak institute Medical Sciences (SRMSIMS) Bareilly (U.P). Objective assess knowledge and postpartum contraception factors affecting usage contraceptives Rural area. All females who delivered within last one year were included study. pre-structured questionnaire used....
Tandem mass spectrometry (TMS) -based screening for homocystinuria in the routine newborn (NBS) primarily relies on elevated levels of methionine (Met) dried blood spot (DBS) affected neonates. However, due to lack required specificity Met as a marker homocystinuria, an additional re-sampling and follow-up analytical testing definitive diagnosis, emphasis us develop second-tier more specific marker, that is homocysteine (HCY) same residual without any new sample. Objective: The objective...