A5082052681- Chronic Myeloid Leukemia Treatments
- MicroRNA in disease regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cardiac Fibrosis and Remodeling
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- Macrophage Migration Inhibitory Factor
- Extracellular vesicles in disease
- Congenital heart defects research
- GDF15 and Related Biomarkers
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- T-cell and Retrovirus Studies
- Platelet Disorders and Treatments
- Mesenchymal stem cell research
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Cytokine Signaling Pathways and Interactions
Northwestern University
2021-2024
Lurie Children's Hospital
2021-2024
Versiti Blood Center of Wisconsin
2023-2024
Maulana Azad Medical College
2014-2021
University of Delhi
2016-2021
Northwest University
2021
Cancer Genetics (United States)
2015
The present study was conducted from July 1, 2020 to September 25, in a dedicated coronavirus disease 2019 (COVID-19) hospital Delhi, India provide evidence for the presence of severe acute respiratory syndrome 2 (SARS-CoV-2) virus atmospheric air and surfaces wards. Swabs (patient's bed, ward floor, nursing stations area) suspended particulate matter ambient were collected by portable sampler medicine ward, intensive care unit, emergency admitting COVID-19 patients. By performing...
Background: Epithelial ovarian cancer continues to be a deleterious threat women as it is asymptomatic and typically detected in advanced stages. Cogent non-invasive biomarkers are therefore needed which effective apprehending the disease early Recently, miRNA deregulation has shown promising magnitude tumorigenesis. miRNA-145(miR- 145) beginning understood for its possible role development progression. In this study, we identified clinicopathological hallmarks altered owing downexpression...
Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome, an abnormally shortened chromosome 22. It result of a reciprocal translocation chromosomes 9 and 22, creating BCR-ABL fusion transcripts, b3a2, b2a2, e1a2. The aim our study was to determine type transcripts for molecular diagnosis investigate frequency in CML patients multiplex RT-PCR CML.A single reaction with multiple primers PCR used detect 200 among which 116, 33, 51 were CP, AP, BC phase, respectively.The...
MicroRNA miR-486-5p has been reported as a potential biomarker for diagnosis, prognosis, and therapeutic target in various cancers. In this study, we analyzed alterations the expression of chronic Myeloid Leukemia (CML) patients. Initially, was studied BCR-ABL1+ve CML K562 cell line by quantitative real-time polymerase chain reaction (qRT-PCR). The results indicated that significantly upregulated cells after imatinib exposure, compared to untreated (p-value = 0.047). These observations were...
Background: The aim of this review and meta-analysis was to identify, assess, meta-analyze summarize the comparative effectiveness safety filgrastim in head-to-head trials with placebo/no treatment, pegfilgrastim (and biosimilar update advances field. Methods: preferred reporting items for systematic reviews meta-analyses PRISMA statement were applied, a random-effect model used. Primary endpoints rate duration grade 3 or 4 neutropenia, an incidence febrile neutropenia. Secondary time...
Human phospholipase A 2 group IIa (sPLA IIa) is an inflammatory enzyme that plays a significant role in tumorigenesis. Inhibiting the sPLA with effective molecule can reduce response and halt cancer progression. The present study evaluates quercitrin, biflavonoid, for inhibition anticancer activity. Quercitrin inhibited activity to greater extent—at 86.24% ± 1.41 IC 50 value of 8.77 μM 0.9. nature was evaluated by increasing calcium concentration from 2.5 15 µM substrate 20 120 nM, which did...
There is strong evidence that disease progression, drug response and overall clinical outcomes of CML are not only decided by BCR/ABL1 oncoprotein but depend on accumulation additional genetic epigenetic aberrations. DNA hydroxymethylation implicated in the development variety diseases. gene promoters plays important roles outcome various Therefore this study, we aimed to explore role aberrant promoter regions different tumor suppressor genes relation imatinib therapy outcome.
To investigate the methylation pattern in promoter region of RASSF1A and PTEN genes epithelial ovarian cancer patients North India. Fifty 20 healthy controls were studied. Isolation genomic DNA from peripheral blood methylation-specific polymerase chain reaction (MSP) applied for analysis. 17 50 (34.0%) found to be methylated gene, whereas gene occurred 8 cases (16.0%). A statistically significant result was obtained (P = .01) correlated with patients' clinicopathologic features....
Abstract Background Despite promising results in clinical studies, the mechanism for beneficial effects of allogenic cell-based therapies remains unclear. Macrophages are not only critical mediators inflammation but also players cardiac remodeling. We hypothesized that transplanted rat progenitor cells (rCPCs) augment T-regulatory which ultimately promote proliferation M2 like macrophages by an as-yet undefined mechanism. Methods and To test this hypothesis, we used crossover strains...
Background: Chronic myeloid leukaemia (CML) is a myeloproliferative disorder categorized by malignant transformation of single stem cell hematopoietic cells. microRNAs (miRNAs) belong to transcription regulators in hematopoiesis and their altered expression associates with pathogenesis CML. Aim: Current study aimed access the miR-21 profile CML patients therapy response as well its prognostic significance. Methods: 100 cases, controls were included was analyzed. Overall 9.22 mean fold...
Background: Mammalian cells contain three functional RAS proto-oncogenes, known as H-RAS, K-RAS, and N-RAS, which encode small GTP-binding proteins in terms of p21 ras s. genes have been elucidated major participants the development progression cancer. A single nucleotide polymorphism (SNP) at H-RAS cDNA position 81 T→C (rs12628) has found to be associated with risk many human cancers like gastrointestinal, oral, colon, bladder thyroid carcinomas. Therefore, we hypothesized that this...
RIZ1 encodes a retinoblastoma (Rb)-interacting zinc finger protein, is commonly lost or expressed at reduced levels in cancer cells. The gene locus undergoes LOH many cancers. Here, we analyzed Proline insertion–deletion polymorphism amino acid position 704 the and its association with CML. pro-704 genotypes were determined by AS-PCR 100 CML patients among which 50 CP-CML, 25 AP-CML, BC-CML. Pro704 ins/del (LOH) was detected 27% patients. ins–ins homozygosity, del–del homozygosity ins–del...
One of the emerging treatment strategies for cancer particularly haematological malignancies is natural killer (NK) cell therapy. However, availability a best approach to maximize NK anticancer potential still awaited. It well established that cytokine-induced memory-like cells have differentiate after short period preactivation with interleukins-IL-12, IL-15, and IL-18 exhibit increased responses cytokine or activating receptor restimulation weeks months preactivation. We demonstrated...
MicroRNAs (miRNAs) have been observed to exhibit altered expression patterns in chronic myeloid leukemia (CML). Therefore, this study was aimed evaluate the clinical importance of miR-126 and miR-122 concert imatinib response CML patients.The present included 100 healthy subjects. The 2 miRNAs performed using TaqMan probe chemistry, snU6 used as internal control.The downregulated patients, with a mean fold change ± SD 0.20 0.33 0.22 0.37, respectively. While both analysed before after...
Introduction Glutathione S-transferase (GST) gene deletion or polymorphic sequence variations lead to decreased enzyme activity that influences susceptibility and response chemotherapy in acute lymphoblastic leukemia (ALL). This case–control study investigated the association of GST polymorphisms with etiology therapeutic outcome B-ALL among Kashmiri population. Methods A total 300 individuals including 150 newly diagnosed patients an equal number age gender matched controls were genotyped...
Platelet-derived growth factor receptor has been implicated in many malignant and non-malignant diseases. receptor-α is a tyrosine kinase side target for imatinib, revolutionary drug the treatment of chronic myeloid leukemia that dramatically improved survival patients. Given importance platelet-derived platelet development its inhibition by it was intriguing to analyze role relation imatinib imatinib-induced thrombocytopenia We hypothesized two known functional polymorphisms, +68GA...
Introduction: Epilepsy is the most common heterogeneous neurological disorder affecting approximately 42 million people worldwide. Juvenile myoclonic epilepsy (JME) a form of idiopathic generalized representing 5-10% all cases. Lennox-Gastaut syndrome (LGS) one severe epileptic encephalopathies childhood onset, cause which may be symptomatic, i.e., secondary to an underlying brain or cryptogenic, with no known cause. Sodium channels are integral membrane proteins play central role in...