A5040043335- Natural product bioactivities and synthesis
- Nanoparticles: synthesis and applications
- Natural Antidiabetic Agents Studies
- Graphene and Nanomaterials Applications
- Plant and fungal interactions
- Copper-based nanomaterials and applications
- Healthcare and Venom Research
- Melamine detection and toxicity
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects of Medicinal Plants
- Ethnobotanical and Medicinal Plants Studies
- Pineapple and bromelain studies
- Plant Pathogens and Fungal Diseases
- Advanced Drug Delivery Systems
- Phytochemical compounds biological activities
- Bioactive Compounds and Antitumor Agents
- Chemical synthesis and alkaloids
- Pharmacological Effects of Natural Compounds
- Microencapsulation and Drying Processes
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Bee Products Chemical Analysis
- Biochemical and Structural Characterization
- Diabetes Treatment and Management
- Protein Kinase Regulation and GTPase Signaling
Mangalore University
2022-2025
Kuvempu University
2023
Abstract This study presents a novel approach to synthesizing silver nanoparticles (Ag NPs) using solution combustion synthesis (SCS) method with Catharanthus roseus ( C. ) leaf extract. The NPs were thoroughly characterized through X‐ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive (EDX), Transmission (TEM), and Selected area (SAED), elucidating their crystal structure. Notably, the synthesized Ag exhibited significant dose‐dependent decline in viability of...
Human group IIA secreted phospholipase A2 (GIIA) is a key enzyme in inflammatory reactions, worsening the condition of several chronic diseases. The natural inhibitors GIIA potentially block production mediators. In present study, elemolic acid, triterpenoid from Boswellia serrata inhibited concentration-dependent manner with IC50 value 5.70 ± 0.02 µM. mode inhibition was studied by increasing concentration substrate 30 to 120 nM, and calcium 2.5 15 mM, level not changed. inhibitor-enzyme...
Human phospholipase A 2 group IIa (sPLA IIa) is an inflammatory enzyme that plays a significant role in tumorigenesis. Inhibiting the sPLA with effective molecule can reduce response and halt cancer progression. The present study evaluates quercitrin, biflavonoid, for inhibition anticancer activity. Quercitrin inhibited activity to greater extent—at 86.24% ± 1.41 IC 50 value of 8.77 μM 0.9. nature was evaluated by increasing calcium concentration from 2.5 15 µM substrate 20 120 nM, which did...
The use of photocatalysts without noble metals is great interest in the industrial field for degradation organic pollutants. In this study, a CuO/ZnO heterostructure was synthesized using microwave hydrothermal method and characterized various analytical techniques. photocatalyst exhibited low bandgap energy 2.4 eV, enabling efficient visible light absorption. photocatalytic activity evaluated Methyl Orange (MO) dye showed high efficiency 99 % due to its excellent electron-hole charge...
Background: Inflammation is generally connected to tumour progression and development. The secretory phospholipase A2IIa (sPLA2IIa) an important inflammatory enzyme that catalyse the hydrolysis of membrane phospholipids into arachidonic lysophosphatidic acid, which are precursors for production a lot pro-inflammatory mediators like prostaglandins, prostacyclins, thromboxanes, leukotrienes platelet activating factors, involved in proliferation, migration, invasion, metastasis. Therefore,...
In treating type 2 diabetes, avoiding glucose reabsorption (glucotoxicity) and managing hyperglycemia are also important. A metabolic condition known as diabetes (type-2) is characterized by high blood sugar levels in comparison to normal Bilosomes (BLs) containing Dapagliflozin (Dapa) were formulated, optimized, tested for oral therapeutic efficacy the current investigation. Used Box Behnken design optimize Dapa-BLs, formulated via a thin-film hydration technique. Bile salts (X1)...
Human Group IIA secreted phospholipase A2 (sPLA2-IIA) enzyme plays a crucial role in several chronic inflammatory diseases such asasthma, atherosclerosis, gout, bronchitis, etc. Several studies showed that the antioxidants exert an anti-inflammatory function by inhibiting sPLA2-IIA enzyme. Hence, present study evaluated antioxidant molecule, sinapic acid, for inhibition as function. Initially, efficacy of acid was evaluated, and it greater potency. Further, inhibited 94.4 ± 4.83% activity...
Introduction and Aim: Garcinia indica is a wild edible fruit plant distributed in tropical regions of India. Fruits G. were traditionally used to treat chronic inflammatory diseases like rheumatoid arthritis, gastrointestinal disorders, etc., But the basis anti-inflammatory function not understood. Therefore, this study aims evaluate indica. Initially phytochemical screening was carried out, tested antioxidant potency evaluated its by inhibition secretory phospholipase A2 IIA (sPLA2IIA)...
Introduction and Aim: Worldwide, mosquitoes are the main vectors of many deadly diseases like malaria, dengue, chikungunya, etc., Anopheles stephensi mosquito which transmits malaria whereas dengue is transmitted mainly by Aedes aegypti. Current controlling methods such as chemical or microbial pesticides, repellents, biological control agents against larvae not so effective. The leading cause death worldwide cancer. Nanotechnology can provide alternative effective for cancer control,...