A5021762811- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Advanced Drug Delivery Systems
- Biosimilars and Bioanalytical Methods
- Drug Solubulity and Delivery Systems
- Antibiotics Pharmacokinetics and Efficacy
- Synthesis and biological activity
- Psoriasis: Treatment and Pathogenesis
- Multicomponent Synthesis of Heterocycles
- Analytical Chemistry and Sensors
- Natural Antidiabetic Agents Studies
- Pharmacogenetics and Drug Metabolism
- Pesticide Residue Analysis and Safety
- Alzheimer's disease research and treatments
- Traditional Chinese Medicine Analysis
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Cancer Research and Treatment
- Axon Guidance and Neuronal Signaling
- Curcumin's Biomedical Applications
- Ginkgo biloba and Cashew Applications
- Natural Compound Pharmacology Studies
- ZnO doping and properties
- Wnt/β-catenin signaling in development and cancer
Advanced Numerical Research and Analysis Group
2012-2025
Galgotias University
2024
CT Group Of Institutions
2018
The present study was designed with an aim to develop and optimize naproxen proniosomes (NAPRNs) using Box–Behnken Design (BBD). formulation optimized three independent variables [maltodextrin (X1), surfactant concentration (X2) drug (X3)] at different levels (low, medium high). prepared fifteen formulations were evaluated for entrapment efficiency, vesicle size transdermal flux select the niosomes (NAPRNopt). developed NAPRNs showed nano-size (218–417 nm) high encapsulation efficiency...
ABSTRACT Paxalisib is a dual PI3K/mTOR inhibitor, being used in advanced cancer treatment. In this research, we report validated LC–MS/MS method for quantifying paxalisib from mouse dried blood spot (DBS). We the in‐line with FDA guidelines. Liquid–liquid extraction technique was to extract DBS discs. Chromolith RP‐18 end cap (100 × 4.6 mm) column and isocratic mobile phase chromatographic separation of internal standard (IS, dasatinib). The flow 0.80 mL/min. optimized conditions, retention...
P-glycoprotein (P-gp) is known as the "multidrug resistance protein" because it contributes to tumor several different classes of anticancer drugs. The effectiveness such polymers in treating cancer and delivering drugs has been shown a wide range vitro vivo experiments. primary objective present study was investigate inhibitory effects naturally occurring on P-gp efflux, that inhibition can impede elimination medications. our identify possess potential inhibit P-gp, protein involved drug...
The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. These compounds were filtered by using ADMET, drug-likeness characteristics calculations, molecular docking experiments. Compounds 27, 29, 30, 33, 37, 38, 41 chosen for synthesis based on results in silico screening. Each synthesized was tested its vitro antibacterial antifungal activities a variety strains. All showed...
A satisfactory LC-MS/MS separation and good peak symmetry for Atrasentan were obtained with Agilent, Zorbax, XDB C18 (2.1 x 50 mm ID, 5 μm), a mobile phase containing mixture of mM Ammonium Formate buffer 0.1% formic acid mixed HPLC grade Acetonitrile in the proportion 70:30, v/v was delivered at flow rate 0.150 mL/min by positive ion mode (API 4000) an injection volume 10 µL run time 3 min. Detection is performed atmospheric pressure electrospray ionization (ESI) mass spectrometry mode. The...
>For the analytical determination of ipilimumab employing cetuximab as a reference standard, simple, fast, accurate, robust, and repeatable LC-MS/MS methodology was devised. This study investigated current developments in methodologies. The Waters symmetry C18 column (150 x 4.6 mm, 3.5) employed at ambient temperature under isocratic elution. Acetonitrile (ACN) 0.1% aqueous solution formic acid were utilized mobile phase 1.0-mL per min flow rate. injection volume 10 μL, operation period 7...
Sonochemistry under controlled conditions has proven effective in medicinal chemistry and drug development. It can substantially shorten reaction timelines from days or hours to minutes. A convenient one-pot synthesis of 2,4,5-trisubstituted 1,2,4,5-tetrasubstituted imidazole derivatives catalyzed by PTSA benzenesulfonic acid ethanol as solvent, ultrasonic irradiation without ultrasound at 50° C been achieved successfully. These were also accomplished using different solvents viz., Methanol,...
Transdermal drug delivery technology generated tremendous excitement and interest amongst major pharmaceutical companies in the 1980s 90s.Ethosomes are ethanolic phospholipid vesicles which used mainly for transdermal of drugs.Ethosomes have higher penetration rate through skin as compared to liposomes hence these can be widely place liposomes.Ethosomes become an area research interest, because its enhanced permeation, improved delivery, increased entrapment efficiency etc.The purpose...
Over the last decade, health care enabled services and accompanying advanced technology have been subject of much research. Medical equipment, sensors, healthcare professionals may all be linked through Internet Things (IoT) to deliver high-quality medical everywhere. Patient safety has improved as a consequence, costs decreased, access grown, sector whole become more efficient productive. According recent study, (IoT)-based technologies offer enormous promise for enhancing care. The most...
Plaque psoriasis is a common, long-lasting illness that affects the immune system and causes significant negative impacts on patient's physical health, well-being, ability to work effectively. Deucravacitinib (DEU) first oral medication used in treatment of plaque psoriasis, chronic skin condition red, scaly patches skin. DEU type called an Janus kinase (JAK) inhibitor, which works by blocking specific enzymes play role inflammation response associated with psoriasis. Therefore, quick, easy,...
A simple, accurate, precise, economical and reproducible UV Spectrophotometric method has been developed for the simultaneous estimation of Atenolol Chlorthalidone in bulk combined tablet dosage form.The stock solutions were prepared methanol followed by further required dilutions with methanol.The absorbance maxima found to be 225nm & 284nm respectively.Beers law obeyed concentration range atenolol is 10 µg mL -1 60 chlorthalidone 30 140 .The results analysis validated statistically...
The current work focuses on analysing the structural, optical, and anti-fungal efficacy of ZnO nanoparticles using well diffusion agar methods minimum inhibitory concentration (MIC). were created sol gel method. To check synthesized material's spatial optical characteristics, XRD, UV, RAMAN studies performed. median diameter produced nanostructures is in region nanometre, according to XRD measurements. Results from Raman Spectroscopy for nanostructure are provided, together with comparisons...
The term “antivirals” has been associated with COVID-19 during the period when usage of this specific class medications increased. Nirmatrelvir, a protease inhibitor, is used to treat mild moderate symptoms by stopping SARS-COV-2 reproduction. With deucravacitinib serving as internal standard, liquid chromatography-tandem mass spectroscopy in human plasma was provide quick, simple, innovative, trustworthy, and sensitive approach. Liquid-liquid extraction separate nirmatrelvir standard....
In treating type 2 diabetes, avoiding glucose reabsorption (glucotoxicity) and managing hyperglycemia are also important. A metabolic condition known as diabetes (type-2) is characterized by high blood sugar levels in comparison to normal Bilosomes (BLs) containing Dapagliflozin (Dapa) were formulated, optimized, tested for oral therapeutic efficacy the current investigation. Used Box Behnken design optimize Dapa-BLs, formulated via a thin-film hydration technique. Bile salts (X1)...
A simple, specific, accurate, precise and stability-indicating reverse phase high performance liquid chromatography (RP-HPLC) method is developed for estimation of Valsartan in tablet dosage form. The employed, Phenomenox C 18 , 5µm,25cm x 4.6 mm i.d. column isocratic mode, with mobile methanol & phosphate buffer pH 3.0 ratio 65:35(v/v) . flow rate was 1mL min -1 effluent monitored at 210 nm. Retention time found to be 6.22 min. validated terms Linearity, accuracy, precision, limit detection...
In the twenty-first century, nanotechnology has become cutting-edge technology. It is interdisciplinary and multidisciplinary, covering numerous fields such as medicine, engineering, biology, physics, material sciences, chemistry. The present work aims to cover optical properties, method of preparations, surface modifications, bio-conjugation, characterization, stability, cytotoxicity quantum dots (QDs). Articles were reviewed in English literature reporting pharmaceutical bio-pharmaceutical...