A5101847592- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Kruppel-like factors research
- Nuclear Structure and Function
- Microtubule and mitosis dynamics
- Cancer-related gene regulation
- RNA regulation and disease
- Immune Response and Inflammation
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Renal and related cancers
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Cellular transport and secretion
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Digestive system and related health
- Kidney Stones and Urolithiasis Treatments
China Medical University
2015-2025
To study the regulatory effect of lncRNA HOTAIR/miR-20a-5p/HMGA2 axis on breast cancer (BC) cell growth, mobility, invasiveness, and apoptosis. The microarray data lncRNAs mRNAs with differential expression in BC tissues were analyzed Cancer Genome Atlas (TCGA) database. LncRNA HOX transcript antisense RNA (lncRNA HOTAIR) was assessed by qRT-PCR. Cell viability confirmed using MTT colony formation assay. apoptosis TdT-mediated dUTP nick-end labeling (TUNEL) mobility invasiveness testified...
Abstract We investigated thoroughly the effect of lncRNA PART1 on prostate cancer cells proliferation and apoptosis, through regulating toll-like receptor (TLR) pathways. LncRNA expression was also examined by quantitative real-time polymerase chain reactions (qRT-PCR) in human tissues lines LNCaP PC3. After transfection with si-PART1 or control constructs, cell viability measured MTS colony formation assays. In addition, apoptosis rate validated TUNEL staining. Relationships between TLR...
Background/Aims: Next-generation sequencing (NGS) has revealed abundant long noncoding RNAs (lncRNAs) that have been characterized as critical components of cancer biology in humans. The present study aims to investigate the role lncRNA KCNQ1OT1 breast (BRCA) well underlying molecular mechanisms and functions involved progression BRCA. Methods: Cancer Genome Atlas (TCGA) StarBase v2.0 were used obtain required gene data. Dual luciferase reporter assays conducted verify relevant...
Abstract This study was designed to research the influence of activating transcription factor 3 ( ATF 3) on radioresistance breast cancer. expression measured by qRT ‐ PCR and immunohistochemistry. Cancerous cell lines were cultured in vitro, gauged both Western blot before after radiation therapy. Cellular cycle apoptosis analysed flow cytometry. Changes corresponding proteins downstream pathways identified blot. Tumour xenograft used evaluate effect vivo. observed stronger cancer tissues...
RING finger protein 112 (RNF112) exerts a key role in human tumors. However, its biological function colorectal cancer (CRC) has not been discussed. We aimed to explore the and molecular mechanism of RNF112 CRC. In this study, expression was notably decreased CRC tissues cells. Clinical analysis revealed significant association between low tumor size, N classification TNM stage. vitro experiments demonstrated that overexpression repressed cell viability, promoted cycle arrest apoptosis,...
ADP ribosylation factor 6 (ARF6) is a member of the Rat sarcoma virus (RAS) superfamily that involved in regulation vesicular trafficking, membrane lipid remodeling, and signaling pathways. Our earlier work discovered ARF6, as downstream effector Kirsten rat viral oncogene (Kras)/extracellular signal-regulated kinases (ERK) pathway, may increase proliferation induce Warburg effect gastric cancer (GC) cells. Additionally, ARF6 appears to be potential biomarker for predicting prognosis GC....
Rab25 was reported to be associated with several human cancers and malignant biological behavior of cancer cells. The goal the present study determine its expression pattern function in hepatocellular carcinoma (HCC). We examined protein 92 cases HCC tissues 3 cell lines. results showed that upregulated cells compared normal liver line. overexpression correlated advanced tumor stage nodal metastasis. small interfering RNA (siRNA) employed Bel7402 SK-Hep-1 Cell Counting Kit-8 (CCK-8) assay...
The occurrence and development of colon cancer are complex, involving a variety genetic changes, such as mutation activation oncogenes, inactivation tumour suppressor genes, aberrant proliferation apoptosis regulation mechanisms. Fibrous sheath interacting protein 1 (FSIP1) is newly discovered oncogene that frequently activated in tumours breast bladder cancer. However, the clinical significance FSIP1 unclear. In this study, we analysed expression human cancer, aimed to clarify biological...
Abstract Background Bladder cancer (BC) is the most common malignancy of urinary system and cisplatin (DDP) remains only chemotherapy option for treatment BC at advanced stage. The critical molecules involved in regulation resistance are still largely unknown. CircRNAs has been demonstrated to be tumorigenesis development drug various cells. CircCEP128 contributed progression by regulating miR-145-5p/MYD88/MAKP axis. However, functions molecular mechanisms circCEP128 DDP bladder cells remain...