A5101830915- Dialysis and Renal Disease Management
- Monoclonal and Polyclonal Antibodies Research
- Advanced Radiotherapy Techniques
- Parathyroid Disorders and Treatments
- Radiation Therapy and Dosimetry
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Pharmacogenetics and Drug Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Lymphatic System and Diseases
- Lymphatic Disorders and Treatments
- HER2/EGFR in Cancer Research
- Electronic Health Records Systems
- Muscle and Compartmental Disorders
- Physics and Engineering Research Articles
- T-cell and B-cell Immunology
- AI in cancer detection
- Osteoarthritis Treatment and Mechanisms
- Peripheral Artery Disease Management
- Liver Diseases and Immunity
- Vascular Procedures and Complications
- Medical Coding and Health Information
- Genetic Syndromes and Imprinting
- Musculoskeletal synovial abnormalities and treatments
Robert Bosch Hospital
2012-2024
Hospital Roberto del Rio
2021
University of Miskolc
2021
Eaton (United Kingdom)
2016
Malteser Krankenhaus St. Anna
2016
UCLouvain
2014
University Hospital Schleswig-Holstein
2012
University of Lübeck
2012
Robert Bosch (Germany)
1984-2010
University of Szeged
2009
Background— Myocarditis can occasionally lead to sudden death and may progress dilated cardiomyopathy in up 10% of patients. Because the initial onset is difficult recognize clinically diagnostic tools available are unsatisfactory, new strategies diagnose myocarditis needed. Methods Results— Cardiovascular MR imaging (CMR) was performed 32 patients who were diagnosed with by clinical criteria. To determine whether CMR visualizes areas active myocarditis, endomyocardial biopsy taken from...
Background. Encapsulating peritoneal sclerosis (EPS) and simple are important complications of long-term dialysis (PD). Podoplanin is expressed by mesothelial cells lymphatic vessels, which involved in inflammatory reactions the cavity. Methods. We studied 69 biopsies from patients on PD (n = 16), with EPS 18) control taken at time hernia repair 15) or appendectomy 20). Immunohistochemistry was performed to localize podoplanin. Additionally, markers endothelial cells, myofibroblasts (smooth...
Introduction: Secondary hyperparathyroidism develops in nearly all patients with end-stage renal disease. Parathyroidectomy is often performed when medical therapy fails. The most common postoperative complication, hungry bone syndrome (HBS), requires early recognition and treatment. Materials methods: A total of 84 who underwent parathyroidectomy because secondary were investigated. Detailed analysis laboratory parameters (calcium, phosphate, parathyroid hormone, hemoglobin, urea levels)...
Previous studies have described some antibacterial effects of antimicrobial peptides (AMPs) expressed in human skin, but little is known about their possible activity against dermatophytes. Therefore we tested the β-defensin 2 (hBD-2), ribonuclease 7 (RNase 7) and psoriasin on vitro growth four dermatophyte species. Germinating conidia Trichophyton rubrum, T. mentagrophytes, Microsporum canis Epidermophyton floccosum were exposed to hBD-2, RNase 7, fluconazole. Subsequent fungal was measured...
Chronic peritoneal dialysis (PD) can be complicated by encapsulating sclerosis (EPS), the most severe complication associated with long-term PD.In this study, we retrospectively analysed 49 EPS patients regarding clinical presentation, histopathological findings, treatment and outcome at our referral centre. Patients were divided into two categories: mild/moderate.All in group mild/moderate had symptoms consistent EPS. The common computed tomographic findings thickening both groups. Small...
In peritoneal dialysis (PD) patients, the membrane is affected by glucose-based solutions used as dialysate fluids. This exposure leads to changes of which may eventually culminate in fibrosis and method failure. vitro or animal studies demonstrated that glucose transporters are upregulated upon these solutions. Expression human peritoneum have not been reported yet.Expression SGLT-2, GLUT1, GLUT3 biopsies was analyzed real-time polymerase chain reaction Western blot analysis. The...
Although a cholesterol supersaturation of gallbladder bile has been identified as the underlying pathophysiologic defect, molecular pathomechanism gallstone formation in humans remains poorly understood. A deficiency apical sodium acid transporter (ASBT) and ileal lipid binding protein (ILBP) small intestine may result loss into colon might promote by reducing pool increasing amount hydrophobic salts. To test this hypothesis, levels mRNA expression ASBT ILBP were assessed mucosa biopsies...
Abstract Background The medical history is acknowledged as the sine qua non for quality care because recognizing problems pre-requisite managing them. Medical histories typically are incomplete and inaccurate, however. We show here that computers a solution to this issue of information gathering about patients. Computers can be programmed acquire more complete with greater detail across range acute chronic issues than physician histories. Methods Histories were acquired by physicians in...
Encapsulating peritoneal sclerosis (EPS) is a rare but life-threatening complication of dialysis (PD). The optimal management patients with EPS uncertain. In the present study, we investigated differences in expression nuclear receptors [progesterone (PR), androgen (AR), vitamin D (VDR), and glucocorticoid (GCR)] human peritoneum. We also estrogen receptor (ER), matrix metalloproteinase 9 (MMP9), transforming growth factor β1 (TGFβ1) context their potential role tamoxifen therapy.We analyzed...
There are forensic inquiries in which an identification of epithelial cell types would provide important probative evidence. In cancer diagnosis, this information is yielded by histological examination cytokeratin (Ck). Therefore, we tested 19 antibodies against different Cks (Ck1, Ck2e, Ck4, Ck5-6, Ck7, Ck8, Ck9, CK10, Ck13, Ck14, Ck15, Ck16, Ck17, Ck18, Ck19, Ck20, Ck903, PanCkAE1_3, and CAM5-2) on sections epidermis, buccal mucosa, vaginal penis, urogenital tract, rectum could identify...
Secondary hyperparathyroidism (sHPT) is known as a very common complication in patients with chronic kidney disease, and G-protein-coupled calcium-sensing receptor (CaSR), Vitamin D (VDR) Fibroblast growth factor (FGFR)/Klotho complexes seem to be involved its development.Hyperplastic parathyroid glands from 70 sHPT normal tissue 7 were obtained during parathyroidectomy. Conventional morphological immunohistochemical analysis of was performed after dividing each slide 3x3 array.The presence...
Encapsulating peritoneal sclerosis (EPS) is a devastating complication of dialysis (PD), characterized by marked inflammation and severe fibrosis the peritoneum, associated with high morbidity mortality. EPS can occur years after termination PD and, in cases, leads to intestinal obstruction ileus requiring surgical intervention. Despite ongoing research, pathogenesis remains unclear. We performed global transcriptome analysis tissue specimens from patients, patients without EPS, uremic...
Increased local levels of fibrogenic growth hormones contribute substantially to the process encapsulating peritoneal sclerosis (EPS) in animal models.We analyzed probes from patients with normal kidney function (n = 10), and inflammation on PD without 10) EPS 9). We investigated degree fibrosis number vessels vasculopathy. Additionally, we expression NFkappaB, TGFbeta1, TGFbeta1 receptor, TGFbeta2, TGFbeta2 FGF-BP, CTGF VEGF by immunohistochemistry.In EPS, found an exclusive upregulation...
Encapsulating peritoneal sclerosis (EPS) is a life threatening complication of dialysis (PD). Podoplanin glycoprotein expressed by mesothelial cells, lymphatic endothelial and myofibroblasts in biopsies from patients with EPS. To evaluate podoplanin as marker EPS we measured mRNA described the morphological patterns podoplanin-positive cells Included were 20 diagnosis (n = 5), on PD without signs control (uremic not PD, n 5, non-uremic 5). patient revealed significantly elevated levels...
Background Encapsulating peritoneal sclerosis (EPS) commonly presents after dialysis has been stopped, either post-transplantation (PT-EPS) or switching to hemodialysis (classical EPS, cEPS). The aim of the present study was investigate whether PT-EPS and cEPS differ in morphology clinical course. Methods In this European multicenter we included fifty-six EPS patients, retrospectively paired-matched for (PD) duration. Twenty-eight patients developed renal transplantation, whereas other...