Sayit Mahmut Erdoğan
A5085761232- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Hepatitis C virus research
- Oral Health Pathology and Treatment
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Cancer and Skin Lesions
- Virology and Viral Diseases
- Skin Diseases and Diabetes
- Monoclonal and Polyclonal Antibodies Research
- Mathematical Approximation and Integration
- Approximation Theory and Sequence Spaces
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders
- Glycosylation and Glycoproteins Research
- Vaccine Coverage and Hesitancy
University of Copenhagen
2020-2023
Kırıkkale University
2006-2021
Copenhagen University Hospital
2021
Abstract The rapid development of a SARS-CoV-2 vaccine is global priority. Here, we develop two capsid-like particle (CLP)-based vaccines displaying the receptor-binding domain (RBD) spike protein. RBD antigens are displayed on AP205 CLPs through split-protein Tag/Catcher, ensuring unidirectional and high-density display RBD. Both soluble recombinant bind ACE2 receptor with nanomolar affinity. Mice vaccinated or CLP-displayed RBD, formulated in Squalene-Water-Emulsion. RBD-CLP induce higher...
Capsid virus-like particles (cVLP) have proven safe and immunogenic can be a versatile platform to counter pandemics. We aimed clinically test modular cVLP COVID-19 vaccine in individuals who were naive SARS-CoV-2.In this phase 1, single-centre, dose-escalation, adjuvant-selection, open-label clinical trial, we recruited participants at the Radboud University Medical Center Nijmegen, Netherlands, sequentially assigned them seven groups. Eligible healthy, aged 18-55 years, tested negative for...
Abstract As an immune evasion and survival strategy, the Plasmodium falciparum malaria parasite has evolved a protein named VAR2CSA. This mediates sequestration of infected red blood cells in placenta through interaction with unique carbohydrate abundantly exclusively present placenta. Cancer were found to share same expression this distinct carbohydrate, termed oncofetal chondroitin sulfate on their surface. In study we have used conjugation system produce bispecific engager, V-aCD3, based...
Abstract The rapid development of a SARS-CoV-2 vaccine is global priority. Here, we developed two capsid-like particle (CLP)-based vaccines displaying the receptor-binding domain (RBD) spike protein. RBD antigens were displayed on AP205 CLPs through novel split-protein Tag/Catcher ensuring unidirectional and high-density display RBD. Both soluble recombinant RBD, bound ACE2 receptor with nanomolar affinity. Mice vaccinated or CLP-displayed formulated in Squalene-Water-Emulsion. RBD-CLP...
In the present paper, we study some approximation properties of a modified Jain-Gamma operator. Using Korovkin type theorem, first give such Secondly, compute rate convergence this operator by means modulus continuity and weighted spaces. Finally, obtain Voronovskaya theorem