Hypertension and diabetes are among the most important risk factors of cardiovascular diseases. Klotho SIRT1 known as anti-aging with beneficial effects on system. In this study we investigated serum levels in pre-diabetic pre-hypertensive individuals then diabetic hypertensive patients to see their relationship these diseases.229 divided into six groups similar gender age distribution 1-Control (normal BP FBS) 2-pre-diabetic (FBS between 100 125 mg/dl) 3-diabetic ≥ 126 mg/dl),...

The biocompatibility and potential application of graphene-based nanomaterials in biomedicine have been documented. effects polyethylene glycol-graphene quantum dots (GQDs-PEG) on cardiac function rats with myocardial infarction (MI) were examined.Wistar randomly assigned to two main groups, each consisting sham-Veh., MI-Veh., MI+GQDs-PEG at doses 5, 10, 20 mg/kg. MI was induced by the closure left anterior descending (LAD) coronary artery. After MI, GQDs-PEG injected different IP every...

Abstract: Exercise training (Ex) has beneficial effects on cardiovascular diseases by increasing Klotho and SIRT1. This study aimed to investigate whether the impact of Ex myocardial infarction (MI) is mediated through Fifty-six Wistar rats were divided into 4 main groups Sham, MI, Ex, MI + Ex. was induced closure left anterior descending. Animals trained endurance exercise for weeks. In end, hemodynamic heart contractility indices assessed. The levels SIRT1 in serum measured enzyme-linked...

Abstract Background Nephrotoxicity is the major side effects of aminoglycoside antibiotics such as gentamicin. The aim this study was to investigate therapeutic Z.multiflora (ZM) hydroalcoholic extract on gentamicin-induced nephrotoxicity. Methods Twenty-eight male Wistar rats categorized into four groups: 1) control group without injection, 2) gentamicin treated (100 mg/kg, i.p) 3) and Z. Multiflora group; extract(0.8 mg/ml in drinking water) administered after 4) normal saline (0.8...

Because of high prevalence coronary artery diseases (CADs) in Iran and their relationship with low physical activity (LPA), this study aimed to measure the epidemic size LPA, its incidence rate, other CAD risk factors Kerman, Iran.About 10,000 adults were randomly recruited through single-stage cluster sampling. Demographic characteristics, biochemical variables, smoking, opium use, mental status, activities assessed. The between LPA 7 was measured. Five-year rate calculated according data...

Summary Apelin receptors ( APJ ) cross‐talk with other G‐protein‐coupled receptors. However, the role of interaction opioid OPR on cardiovascular effects apelin in hypertension is not clear. Renovascular was induced by placing a Plexiglas clip left kidney rats. After 16 weeks, F13A (an antagonist), naloxone (a general inhibitor), and nor‐binaltorphimine dihydrochloride (nor‐ BNI ; selective inhibitor KOR were given prior to injections at doses 40 60 μg/kg. The arterial systolic/diastolic...

Cardiac ischemic preconditioning (Pre) reduces cardiac ischemia-reperfusion injury (IRI) by stimulating opioid receptors. Chronic use of opioids can alter the signaling pathways. We investigated effects chronic methadone on IRI and Pre. The experiments were performed isolated hearts male Wistar rats in four groups: IRI, Methadone + (M-IRI), Pre (Pre-IRI), (M-Pre-IRI). infarct size (IS) Pre-IRI group was smaller than (26.8% vs. 47.8%, P < 0.05). In M-IRI M-Pre-IRI groups, similar to group....

Abstract: Apelin and its receptor are expressed in many tissues play an important role maintaining the homeostasis of cardiovascular system body fluids. Also, association this with diseases, such as diabetes, hypertension, obesity, cancer, diabetic retinopathy, etc., has been determined. This is considered a therapeutic goal mentioned diseases. G protein-coupled receptors (GPCRs) have ability to form oligomers dimers themselves other receptors. The formation these associated change signaling...

Apelin/APJ system plays an important role in the regulation of myocardial contractility (MC) and blood pressure. Opioid receptors (OPRs) are also cardiovascular regulators exert many their effects through modulating function other systems. This study analyzed interaction between APJ kappa OPRs (KOR) cardiac responsiveness to apelin acute reno-vascular hypertension (2K1C).MC studies were carried out on 2K1C rats. F13A (APJ blocker), Naloxone (OPR inhibitor), nor-Binaltorphiminedihydrochloride...

Background: The aim of this study was to examine the renoprotective effect hydro alcoholic sage (Salvia Officinalis: SO) leaves extract against gentamicin-induced nephrotoxicity in rats. Methods: In experimental forty male sprague dawley rats weighing 200-300 g were randomly divided into 5 groups; (1) without treatment (control), (2) intraperitoneally injected with normal saline for one week (sham), (3) gentamicin 80 mg/kg/day, 7 days (GEN), (4) at 50 mg/kg/day plus (80 mg/kg/day) (GEN+SO...

To evaluate Klotho and SIRT1 expression in the heart kidneys of rats with acute chronic renovascular hypertension.Four sixteen weeks after induction hypertension by clipping left renal artery, systemic blood pressure, serum angiotensin II level, proteins oxidative stress indices were assessed.SIRT1 level was significantly reduced ischemic (left) kidney phases hypertension. In heart, it decreased phase, but increased phase. levels did not change either Superoxide dismutase (SOD) activity...

Insulin is proved to have angiogenic ability thereby may worsen the diabetic retinopathy (DR) progression. also triggers expression of endogenous peptide, apelin. Since protamine was introduced as an inhibitor apelin receptor, we hypothesized that use protaminated insulin instead non-protaminated can decrease negative role in progression DR. Firstly, incidence DR compared among three patient groups: oral medication, insulin, and (PIns). Proliferation migration rate HUVECs measured after...