Gentamycin, contrary to its wide range of antimicrobial effects, has a high potential for nephrotoxicity, and renal injury can have effects on other organs such as the liver.The aim present study was assess hydro alcoholic Malva sylvestris(MS) extract nephrotoxicity induced by gentamicin, also remote organ in liver.Renal hepatic functions were evaluated through measurement creatinine, urea-nitrogen, aspartate aminotransferase (AST), alanine (ALT) alkaline phosphatase (ALP) plasma. Oxidative...

Crocus sativus (saffron) has been widely used in traditional medicine. It also found to possess many beneficial properties modern The most important ingredients of saffron are crocin, crocetin, safranal, and picrocrocin. This study evaluated the protective effects crocin against inflammation, oxidative stress, functional disturbances kidney induced by renal ischemia/reperfusion (I/R).Different doses (0, 100, 200, 400 mg/kg) were administered intraperitoneally 30 min before I/R. rats sham...

Inflammation is one of the major challenges in management ischaemia/reperfusion (I/R)-induced acute kidney injury. Our aim was to assess anti-inflammatory and protective effects saffron extract against I/R-induced renal disturbances.A total 35 male Wistar rats were randomly divided into five groups (n = 7) as sham, I/R three that pretreated with different doses (5 mg/kg, 10 or 20 mg/kg) intraperitoneally. The inflammation assessed by measuring leukocyte infiltration mRNA expression levels...

Mallow (Malva sylvestris L.) has had medicinal and therapeutic uses in addition to its oral consumption. The present study was conducted examine the protective effect of Malva L. extract on ischemia-reperfusion-induced kidney injury remote organ injuries liver. Before ischemia-reperfusion, rats different groups received intraperitoneal normal saline or mallow at doses 200, 400 600 mg/kg body weight. After 30-minutes bilateral renal ischemia followed by 24-hours reperfusion, tissue damage...

Renal ischemia-reperfusion is associated with inflammation and oxidative stress. As a major compound in black pepper, piperine has anti-inflammatory anti-oxidative properties. In present study, the protective effects of oral administration renal (IR) induced acute kidney injuries (AKI) were investigated.Male Wistar rats received (10 or 20 mg/kg.bw) vehicle for 10 days. The artery vein both kidneys then clamped 30 min, followed by 24-h reperfusion period. Concentrations creatinine...

Gentamicin (GM) is one of the commonest causes drug-induced nephrotoxicity. Moreover, oxidative stress plays an important role in gentamicin-induced The current study aimed to explore antioxidant and protective effects Pimpinella anisum (P. anisum) on alleviation GM-induced damage.Forty male wistar rats were divided into four groups: control, sham that was administrated normal saline orally intraperitoneally (i.p.), GM received 100 mg/kg bw/day i.p., ethanolic extract P. at oral dose 300 for...

What is the central question of this study? A1 -Adenosine receptor (A1 AR) blockade before renal ischaemia aggravated kidney injury after 24 h reperfusion in several studies, whereas we previously observed a renoprotective effect AR during 4 period. are underlying mechanisms for biphasic pretreatment with an antagonist at and reperfusion? main finding its importance? protects against ischaemia-induced early hours by attenuating reduction blood flow lowering energy expenditure, inflammatory...

Remote organ injury is one of the complications which are developed following ischemia-reperfusion induced acute kidney (AKI), dramatically increasing its mortality rate. The aim present study was to investigate effect piperine pretreatment on liver dysfunction AKI.Acute by 30 min-bilateral renal ischemia followed 24 h reperfusion. To damages, levels aspartate aminotransferase (AST), alanine (ALT), and alkaline phosphatase (ALP) enzymes were measured in plasma. In order oxidative stress,...

In this paper the reaction enthalpies of three antioxidant action mechanisms, HAT, SET–PT, and SPLET, for mono-substituted Stobadines were calculated in gas-phase water. Results show that electron-withdrawing substituents increase bond dissociation enthalpy (BDE), ionization potential (IP), electron transfer (ETE), while electron-donating ones cause a rise proton (PDE) affinity (PA). comparison to gas-phase, water attenuates substituent effect on all enthalpies. IP BDE values can be...

In this paper, the study of various ortho and meta–substituted Sesamol derivatives is presented. The reaction enthalpies related to three antioxidant action mechanisms HAT, SET–PT, SPLET for substituted Sesamols, have been calculated using DFT/B3LYP method in gas phase water. Calculated results show that electron-withdrawing substituents increase bond dissociation enthalpy (BDE), ionization potential (IP), electron transfer (ETE), while electron-donating ones cause a rise proton (PDE)...

Abstract In this paper, the study of various ortho- and meta-substituted tyrosol derivatives is presented. The reaction enthalpies related to three antioxidant action mechanisms HAT, SET-PT, SPLET for substituted tyrosols have been calculated using DFT/B3LYP method in gas phase water. Calculated results show that electron-withdrawing substituents increase bond-dissociation enthalpy (BDE), ionization potential (IP), electron-transfer (ETE), while electron-donating ones cause a rise...

It has been shown that adipose-derived mesenchymal stem cells (AD-MSC) have protective effects in acute kidney injury (AKI). This study was conducted to assess the therapeutic of AD-MSC rats subjected by 45 min renal ischemia followed 48 hr reperfusion (I/R).28 male Wistar were divided into four groups, including control, 48-hr sham, I/R, and I/R receiving AD-MSC. After reperfusion, blood samples taken from rats' hearts, 24-hr urines collected using a metabolic cage. Serum creatinine level...