A5065156020- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Cervical Cancer and HPV Research
- SARS-CoV-2 and COVID-19 Research
- Anorectal Disease Treatments and Outcomes
- Hepatitis B Virus Studies
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Meta-analysis and systematic reviews
- Cytokine Signaling Pathways and Interactions
- Antibiotics Pharmacokinetics and Efficacy
- Multiple Sclerosis Research Studies
- Glycosylation and Glycoproteins Research
- Signaling Pathways in Disease
- TGF-β signaling in diseases
- Research on Leishmaniasis Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical and Molecular Research
- Lipid metabolism and disorders
- Eosinophilic Esophagitis
- BRCA gene mutations in cancer
Islamic Azad University of Kermanshah
2020-2024
Islamic Azad University Kerman
2020-2024
Isfahan University of Medical Sciences
2014-2023
Iran University of Medical Sciences
2015-2021
Tehran University of Medical Sciences
2020
Alzahra Medical and Education Center
2016
miRNAs are involved in various vital processes, including cell growth, development, apoptosis, cellular differentiation, and pathological activities. Circulating can be detected body fluids serum, plasma, saliva, urine. It is worth mentioning that remain stable the circulation biological released from membrane-bound vesicles called exosomes, which protect them RNase activity. has been shown regulate blood-brain barrier integrity by targeting both tight junction adherens molecules also...
Cervical cancer is one of the leading causes cancer-related death in females. Human papilloma virus (HPV) major risk factor cervical cancer.The aim current study was to explore frequency and role 23 different HPVs patients with cancer.Overall, 117 formalin-fix paraffin-embedded (FFPE) tissues from squamous cell carcinoma (SCC) or dysplasia were collected Mirza-Kochakkhan-Jangali hospital, Tehran, Iran during year 2013, investigate presence HPV- 67, 68, 6, 11, 13, 16, 17, 30, 69, 39, 40, 42,...
Gentamicin (GM) is one of the commonest causes drug-induced nephrotoxicity. Moreover, oxidative stress plays an important role in gentamicin-induced The current study aimed to explore antioxidant and protective effects Pimpinella anisum (P. anisum) on alleviation GM-induced damage.Forty male wistar rats were divided into four groups: control, sham that was administrated normal saline orally intraperitoneally (i.p.), GM received 100 mg/kg bw/day i.p., ethanolic extract P. at oral dose 300 for...
Asthma is a chronic and complex inflammatory disease of the respiratory tract. Also, multiple sclerosis (MS) demyelinating central nervous system. Against this background, IL-33 IL1RL1 play critical role in autoimmune disorders. Here, we explored serum level two potential genetic variants IL33 gene its receptor Iranian asthma MS patients.This study consisted (n=140) patients (n=140), healthy subjects (n=72). Genotyping was carried out polymorphisms, rs1342326 variant rs10204137SNP genes,...
The evolution of antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes (ARGs) has been accelerated recently by the indiscriminate application antibiotics. Antibiotic resistance challenged success medical interventions therefore is considered a hazardous threat to human health.The present study aimed describe use zinc finger nuclease (ZFN) technology target disrupt plasmid-encoded β-lactamase, which prevents horizontal gene transfer-mediated ARBs.An engineered ZFN was designed...
Abstract Background Previous studies have shown that CD134 (OX40) co-stimulation is involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) models and antigen expressed within multiple sclerosis lesions humans. OX40 (CD134) thought to be a secondary co-stimulatory immune checkpoint molecule by T cells. This study aimed evaluate mRNA expression its serum levels peripheral blood patients with Multiple Sclerosis (MS) or Neuromyelitis Optica (NMO). Methods Patients MS (n...
BACKGROUND:Multiple sclerosis (MS) is an autoimmune disease of human central nervous system (CNS). OX40 (CD134) a member the tumor necrosis factor (TNF) receptor family. Ligation crucial for clonal expansion antigen-specific T-cells as well survival and generation T-cell m emory. Soluble soluble form it has been demonstrated that correlated with some disorders. OBJECTIVES:The purpose this study was to investigate serum levels gene expression paraclinical marker in MS patients compared...
Abstract Neuromyelitis optica (NMO), also known as Devic’s disease, is an autoimmune disorder of the central nervous system (CNS) in which immune cells and antibodies primarily attack optic nerves spinal cord. OX40 (CD134) a tumor necrosis factor (TNF)-receptor family member expressed on activated CD4 + CD8 T-cells. In typically up-regulated at sites inflammation, increases number peripheral T-cells expressing OX40. its ligand OX40L are key TNF members that augment T-cell expansion, cytokine...