Objective: Chemotherapy with oxaliplatin is used for a wide range of malignancies. Unlike other platinum derivatives, has less nephrotoxicity. However, in recent years, there have been multiple reports different forms renal toxicity related to this agent. Case Summary: A 40-year-old woman colon adenocarcinoma developed jaundice, hematuria, and oliguria after the 36th cycle chemotherapy. Laboratory data revealed severe anemia, thrombocytopenia, increased creatinine, indirect...

Abstract Background The main side effect of gentamicin is nephrotoxicity. cobalamin (Cob) was investigated on nephrotoxicity in rats. Methods Renal injury induced by i.p. injection (100 mg/kg) for 8 consecutive days. Cobalamin (6 mg/kg/day, i.p) treatment done days as co-treatment and post-treatment protocol. Results significantly increased creatinine clearance levels renal blood flow which were reduced gentamicin. Also, improved serum electrolytes (sodium potassium) disturbed compensated...

Meningiomas are the second most common primary intracranial tumors after gliomas. Epigenetic biomarkers such as DNA methylation, which is found in many and thus important tumorigenesis can help diagnose meningiomas predict response to adjuvant chemotherapy. We investigated aberrant O6- methyl guanine methyltransferase (MGMT) methylation meningiomas.Sixty-one patients were classified according WHO grading, MGMT promoter status was examined via methylation-Specific PCR(MSP) method.MGMT 22.2%...

Abstract Background Nephrotoxicity is the major side effects of aminoglycoside antibiotics such as gentamicin. The aim this study was to investigate therapeutic Z.multiflora (ZM) hydroalcoholic extract on gentamicin-induced nephrotoxicity. Methods Twenty-eight male Wistar rats categorized into four groups: 1) control group without injection, 2) gentamicin treated (100 mg/kg, i.p) 3) and Z. Multiflora group; extract(0.8 mg/ml in drinking water) administered after 4) normal saline (0.8...

Introduction: Splenic artery aneurysms (SAAs) are rare (0.2-10.4%); however, they the most common form of visceral aneurysms.Splenic important to identify, because up 25% cases complicated by rupture.Post-rupture mortality rate is -70% based on underlying cause.Herein we present a young patient with abdominal pain after blunt trauma due rupture an SAA.Case Presentation: A 27-year-old male, without remarkable medical history, who suffered from for 2 days falling was admitted emergency...

Abstract Background Ischemia-reperfusion (I-R) leads to acute kidney injury (AKI). The present study investigated the effects of nitroglycerine (NG) on improving renal dysfunctions caused by I-R in rats. Methodology Twenty-four rats were equally divided into four groups: (1) control group, (2) sham (3) and (4) NG-treated groups.NG (50 μg/kg) was injected intraperitoneally after induction IR. induced through clamping bilateral artery vein both kidneys for 20 min followed 24 h reperfusion....

Postoperative outcome of spinal meningiomas is an important issue in surgery decision-making. There are limited and conflicting data the literature about prognostic factors influencing recovery, especially histopathologic subtypes.This study was carried out to evaluate effect some these on postoperative outcome.This performed 39 patients operated for meningioma between October 1998 January 2012; their subtype determined according WHO criteria. The follow up period ranged 8 - 120 months....

Abstract Background Uterine sarcoma accounts for 3–7% of uterine malignant neoplasms. It is more aggressive than epithelial neoplasms, and patients have a poor prognosis. Rhabdomyosarcoma classified as heterologous sarcoma. the most common soft tissue malignancy in children while rare adults. In young patients, majority genital tract rhabdomyosarcomas occur vagina; however, site gynecologic rhabdomyosarcoma cervix followed by corpus, corpus Diagnosis pure uterus involves widespread perfect...

Background: Mature teratoma is a benign neoplasm, mostly composed of well-differentiated derivations almost two or three germ cell layers, while immature malignant neoplasm neural and embryonic tissue. Immature in the context ovarian endometrioma has not been reported yet. Case Presentation: A 34-year-old woman with primary infertility this study who suffered from associated endometrioma. After several rounds fertility treatment, patient was referred for severe abdominal pain underwent...

Background: Paraquat poisoning results in multi-organ failure, primarily pulmonary fibrosis, acute renal and hepatic impairment. The present study was designed to evaluate three treatment regimens, such as N-Acetyl cysteine (NAC), silymarin hydrocortisone the prevention of lung fibrosis after ingestion toxic doses paraquat rats. Methods: Male Sprague-Dawley rats (N=20) were randomly divided into four groups five each. drugs given orally. All rat received one oral dose (10 mg/kg) once daily...

Background and Aim: Deferasirox (Exjade) is an iron-chelating drug used in patients with beta-thalassemia major. Oxidative stress among f the major causes of nephrotoxicity its progression. Deferasirox, due to oxidative increased cell apoptosis dysfunction renal tubules toxicity. According antioxidant anti-inflammatory properties, present study explored effect vitamin C on deferasirox-induced kidney damage. Methods & Materials: This was performed 30 Wistar rats 3 groups control,...

Background: Perivascular Epithelioid Cell Tumors (PEComas) are rare mesen-chymal tumors originating from perivascular epithelioid cells. The second common affected organ is uterine. Most of PEComas benign and patients have good prognosis. At the present time, surgery main treatment adjuvant chemo-therapy used in malignant cases, although best diagnostic management method yet to be discovered considering rarity this neoplasm. Case Presentation: patient was a 53 year old lady with history two...

Despite the use of colonoscopy to detect colon cancer due its aggressiveness, high cost, and lack patient compliance, laboratory tests with accuracy sensitivity, such as tumor marker M2-PK Inhibin A is recommended can be effective for early diagnosis screening patients in stages. We studied 46 admitted it gastrointestinal ward Amir al Momenin Hospital 45 normal (age sex-matched) subjects a control group (case-control retrospective studies). Before colonoscopy, level stool sample serum were...

Objective: Renal ischemia-reperfusion (I-R) induces acute kidney injury (AKI). In this study, the effect of hydralazine was investigated on renal induced by I-R in rats. Methods: AKI with bilateral obstruction artery and vein for 20 minutes following 24 hours reperfusion. Hydralazine (5mg/kg) injected intraperitoneally as post- treatment. Results: significantly increased levels clearance creatinine blood flow, while decreasing I-R. Also, improved serum electrolytes (sodium potassium) that...

Objective: Renal ischemia-reperfusion (I-R) induces acute kidney injury (AKI). In this study, the effect of hydralazine was investigated on renal induced by I-R in rats. Methods: AKI with bilateral obstruction artery and vein for 20 minutes following 24 hours reperfusion. Hydralazine (5mg/kg) injected intraperitoneally as post- treatment. Results: significantly increased levels clearance creatinine blood flow, while decreasing I-R. Also, improved serum electrolytes (sodium potassium) that...

We want to evaluate the effect of Allium noeanum Reut. ex Regel (Bonsor) known (traditional medicine agent) in calcium oxalate stones kidney. 36 male rats were divided into 6 groups. I: healthy model + water, II: negative 1% ethylene glycol III: 750 mg/kg total extract +1% water(Prevention), IV: 250 flavonoid water (Prevention), V: 1500 from 15th day+ (Treatment), VI: 500 study (Treatment).24-hour urine and blood samples collected 30th day for analysis. Pathology kidneys was checked. Serum...