A5101736489- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Vagus Nerve Stimulation Research
- Advanced Photocatalysis Techniques
- TiO2 Photocatalysis and Solar Cells
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Axon Guidance and Neuronal Signaling
- Electrocatalysts for Energy Conversion
- Advanced Nanomaterials in Catalysis
- Tryptophan and brain disorders
- Perovskite Materials and Applications
- Pharmacological Effects of Natural Compounds
- Nuclear Receptors and Signaling
- Angiogenesis and VEGF in Cancer
- Inflammasome and immune disorders
- Retinal Diseases and Treatments
- Connexins and lens biology
- Biochemical Analysis and Sensing Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Barrier Structure and Function Studies
- Medicinal Plants and Bioactive Compounds
- Renal function and acid-base balance
- Paraquat toxicity studies and treatments
Xuzhou No.1 People's Hospital
2024
Xuzhou Medical College
2024
Hebei General Hospital
2017-2023
Tianjin University of Technology
2021-2023
Beijing Geriatric Hospital
2021
Tianjin Medical University
2021
Second Hospital of Tianjin Medical University
2021
Hebei Medical University
2017
Fourth Hospital of Hebei Medical University
2017
Harvard University
2013-2017
The cerebral cortex is essential for integration and processing of information that required most behaviors. exquisitely precise laminar organization the arises during embryonic development when neurons migrate successively from ventricular zones to coalesce into specific cortical layers. While radial glia act as guide rails projection neuron migration, pre-formed vascular networks provide support guidance cues GABAergic interneuron migration. This study provides novel conceptual mechanistic...
The pathogenesis of sepsis associated encephalopathy (SAE) remains poorly understood. Vagus nerve plays an important role in gut-microbiota-brain axis. This study aimed to investigate whether vague is a key mediator the impact intestinal microbiota on SAE.Male rats were randomly divided into four groups (n=20): SHAM (SH) group, lipopolysaccharide (LPS) fecal transplantation (FMT) +LPS and vagotomy (VGX)+LPS+FMT group. left cervical was performed 30min before LPS administration LPS+FMT+VGX...
Current models of brain development support the view that VEGF, a signaling protein secreted by neuronal cells, regulates angiogenesis and development. Here we demonstrate an autonomous pivotal role for endothelial cell-derived VEGF has far-reaching consequences mouse Selective deletion Vegf from cells resulted in impaired marked perturbation cortical cytoarchitecture. Abnormal cell clusters or heterotopias were detected marginal zone, disorganization induced several malformations, including...
ABSTRACT Objective: The aim of the study is to explore impact early serum phosphate levels on prognosis critically ill patients with sepsis. Methods: In this retrospective large cohort study, data sepsis were obtained from Medical Information Mart for Intensive Care IV database. Patients retrospectively divided into a control group and three groups according their daily within 2 days intensive care unit (ICU) admission. A Cox regression model was used evaluate association between 28-day...
Neuronal migration, a key event during brain development, remains largely unexplored in the mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations. Here we study migrational trajectories of DA show that they occupy ventral mesencephalic territory temporally spatially specific manner. Our results from Pitx3-deficient aphakia mouse suggest pre-existing modulate migration to their final destination, providing novel insights fresh perspectives...
To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats.Rats were treated with fecal transplantation, prebiotics, probiotics, synbiotics after exposure lipopolysaccharide. The diversity composition microbiota, electroencephalogram values, concentrations TNF-α, IL-1β, IL-6 cortex analyzed.Fecal transplantation was most efficacious method restore intestinal microbial exert best corrective effects modulating rats. More...
Retinal detachment (RD) is a sight-threatening condition that occurs in several retinal diseases. Microglia reside retina are activated after RD and play role the death of photoreceptor cells. The involvement microglial pyroptosis early pathological process still unclear. VX-765, an inhibitor caspase-1, may exert neuroprotective effects by targeting nervous system disease; however, whether it plays uncertain. This study detected localized to specific cells immunofluorescence co-staining flow...
Rationale: Paraquat is an extremely toxic herbicide with a high mortality rate on poisoning. It can damage vital organs, such as the lungs, liver, heart, and kidneys. In this study, we report case of pulmonary fibrosis after paraquat poisoning in patient who underwent lung transplant procedure preoperative administration corticosteroids immunosuppressive agents continuous noninvasive ventilation support therapy. Patient concerns: An 18-year-old student was hospitalized owing to diarrhea,...
BACKGROUND Fine particulate matter (PM2.5) is the air pollutant that most threatens global public health. The purpose of this study was to observe inflammatory and oxidative stress injury multiple organs induced by PM2.5 in rats explore tissue-protective effect erdosteine. MATERIAL AND METHODS We randomly divided 40 male Wistar into a blank control group, saline exposure an erdosteine intervention group. assessed changes tissue homogenate biomarkers inflammation serum bronchoalveolar lavage...
To investigate the effects of fecal microbiota transplantation on septic gut flora and cortex cholinergic anti-inflammatory pathway in rats.Sixty clean grade male Sprague-Dawley (SD) rats were divided into normal saline (NS) control group, sepsis model group by random number table, with 20 each group. The rat was reproduced injection 10 mg/kg lipopolysaccharide (LPS) via tail vein, NS given same amount NS. received nasogastric infusion feces from healthy donor 1st day, 2 mL time, for 3 times...
A highly active titania surface was constructed by the in situ graphitization of a multifunctional dihydropyridine. An outstanding H 2 O production 10.22 mmol (h g) −1 and solar energy conversion efficiency 2.18% were obtained.
Abstract Background Accumulating evidence suggests that the intestinal flora is involved in many neurodegenerative diseases. Sepsis can lead to severe imbalance and brain dysfunction. In this study, we investigated Sennoside A may relieve lipopolysaccharide(LPS)-associated encephalopathy via its effect on gut microbiota rats. Methods Adult male Sprague-Dawley (SD) rats germ free (GF) were used. The ordinary SD adopted as a LPS-associated model with or without administration. We diversity...