A5100448141- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Thermodynamics and Molecular Structure
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Chemical and Physical Properties in Aqueous Solutions
- Coordination Chemistry and Organometallics
- Thermal and Kinetic Analysis
- Advanced Photocatalysis Techniques
- Crystal structures of chemical compounds
- Synthesis and Reactivity of Heterocycles
- Organometallic Complex Synthesis and Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Thermodynamic properties of mixtures
- TiO2 Photocatalysis and Solar Cells
- Multicomponent Synthesis of Heterocycles
- Analytical chemistry methods development
- Molecular Sensors and Ion Detection
- Electrochemical Analysis and Applications
- Luminescence and Fluorescent Materials
- Petroleum Processing and Analysis
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Crystallography and molecular interactions
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2022-2024
Dalian University of Technology
2024
Tianjin University of Technology
2010-2023
Anhui Normal University
2006-2023
East China Normal University
2023
Hebei University of Technology
2022
Zhejiang A & F University
2022
Office of Science
2021
Gilead Sciences (United States)
1998-2019
Southwest University
2013-2017
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTPractical Total Synthesis of the Anti-Influenza Drug GS-4104John C. Rohloff, Kenneth M. Kent, Michael J. Postich, Mark W. Becker, Harlan H. Chapman, Daphne E. Kelly, Willard Lew, S. Louie, Lawrence R. McGee, Ernest Prisbe, Lisa Schultze, Richard Yu, and Lijun ZhangView Author Information Gilead Sciences Inc., Process Chemistry, 353 Lakeside Drive, Foster City, California 94404 Cite this: Org. Chem. 1998, 63, 13, 4545–4550Publication Date (Web):June 5,...
Enormous effort has been put to the detection and recognition of various heavy metal ions due their involvement in serious environmental pollution many major diseases. The present work developed a single fluorescent sensor ensemble that can distinguish identify variety ions. A pyrene-based fluorophore (PB) containing ion receptor group was specially designed synthesized. Anionic surfactant sodium dodecyl sulfate (SDS) assemblies effectively adjust its fluorescence behavior. selected binary...
Aromatic aldehydes can be directly converted to the corresponding amides and alcohols in good excellent yields by treatment of aromatic with lithium amide LiN(SiMe3)2 presence catalytic lanthanide chlorides LnCl3 or a stoichiometric amount [(Me3Si)2N]3Ln(mu-Cl)Li(THF)3 at ambient temperature. The effects solvents, substitutents on phenyl ring, metals reaction have been examined. mechanism disproportionation was proposed based experimental results.
Abstract A series of rare earth metal amido complexes bearing methylene‐linked pyrrolyl‐amido ligands were prepared through silylamine elimination reactions and displayed high catalytic activities in hydrophosphonylations aldehydes unactivated ketones under solvent‐free conditions for liquid substrates. Treatment [(Me 3 Si) 2 N] Ln(μ‐Cl)Li(THF) with 2‐(2,6‐Me C 6 H NHCH )C 4 NH ( 1 , equiv) toluene afforded the corresponding trivalent amides formula {(μ‐η 5 :η ):η ‐2‐[(2,6‐Me )NCH ](C...
A new multidentate ligand 1-(9-(1H-1,2,4-triazol-1-yl)anthracen-10-yl)-1H-1,2,4-triazole (tatrz) was designed and synthesized. Using tatrz as a building block, three novel coordination frameworks, namely, {[Cu(tatrz)2(NO3)2]·(CH3OH)·4H2O}n (1), {[Cu(tatrz)2(H2O)2](BF4)2}n (2), [Mn(tatrz)2(SCN)2(CH3OH)]·2H2O (3) can be isolated. Anion-exchange experiment indicates that NO3– anions in the two-dimensional (2D) copper framework of 1 completely exchanged by ClO4– an irreversible single...
An efficient synthetic method for the preparation of quinazolin-4-one derivatives was designed. The facile condensation aromatic o-aminonitriles with aldehydes catalyzed by Lewis acid give 1,2-dihydroquinazolin-4(3H)-ones in moderate to good yields under refluxing dimethylformamide.
A modified Friedländer conversion of the cyclocondensation aromatic o ‐aminonitriles with carbonyl compounds was discovered. Systematic studies reveal that both new transformation and classic annulation in presence ZnCl 2 constitute a pair divergent reaction, thecontrolled PDF this reaction achieved present bases.
Abstract Emtricitabine (FTC) and lamivudine (3TC), containing an oxathiolane ring with unnatural (−)-stereochemistry, are widely used nucleoside reverse transcriptase inhibitors (NRTIs) in anti-HIV therapy. Treatment FTC or 3TC primarily selects for the HIV-1 RT M184V/I resistance mutations. Here we provide a comprehensive kinetic structural basis inhibiting by (−)-FTC-TP (−)-3TC-TP drug M184V. have higher binding affinities (1/ K d ) wild-type but slower incorporation rates than dCTP....
Plasma membrane (PM) has very important roles in cell−cell interaction and signal transduction, it been extensively targeted for drug design. A major prerequisite the analysis of PM proteome is preparation with high purity. Density gradient centrifugation commonly employed to isolate PM, but often occurred contamination internal membrane. Here we describe a method plasma purification using second antibody superparamagnetic beads that combines subcellular fractionation immunoisolation...
Abstract As progression-free survival (PFS) has become increasingly used as the primary endpoint in oncology phase III trials, U.S. Food and Drug Administration (FDA) generally required a complete-case blinded independent central review (BICR) of PFS to assess reduce potential bias investigator or local site evaluation. However, recent publications FDA analyses have shown high correlation between evaluation BICR assessments treatment effect, which questions whether is necessary. One...
Although metal–organic frameworks (MOFs) have promising applications in various fields, efforts to utilize MOFs as emissive layers electroluminescent devices not progressed well due their intrinsic nature. Fortunately, by using fluorene derivatives and cuprous ions, a novel MOF (Cu-P6) has been synthesized for blue electrophosphorescence. The topological structure of Cu-P6 displays 3-connected uninodal net with cross-stacking pattern. Such allowed phosphorescent exhibit good heat resistance...
The Cross-PhRMA working group has proposed using the MaxCombo test in place of log-rank to evaluate treatment differences based on time-to-event endpoints, particularly if nonproportional hazards are expected. Despite demonstrating improved power and overall Type I error control, concerns about this for inferential purposes remain. We evaluated by reanalyzing data from six cancer clinical trials submitted U.S. Food Drug Administration. Interpretation results is not clear when Kaplan–Meier...
A randomized, two-way, crossover study was conducted in 18 healthy male Chinese volunteers to compare pharmacokinetics profiles of galantamine hydrobromide dispersible tablet with that conventional tablet. single oral dose 10 mg administrated each volunteer. Plasma concentrations were determined by a validated high-performance liquid chromatography (HPLC) method fluorescence detection, which allowed 1 ng/mL be assayed as the lowest quantifiable concentration. From plasma concentrations,...