A5089778555- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Protein Structure and Dynamics
- Eosinophilic Esophagitis
- Infant Health and Development
- Barrier Structure and Function Studies
- Monoclonal and Polyclonal Antibodies Research
- Pediatric health and respiratory diseases
- Complementary and Alternative Medicine Studies
- Protein purification and stability
- Erythrocyte Function and Pathophysiology
- Agriculture Sustainability and Environmental Impact
- IL-33, ST2, and ILC Pathways
University of Chicago
2022-2024
University of Michigan
2021
BioSurfaces (United States)
2021
The aggregation of amyloidogenic polypeptides is strongly linked to several neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. Conformational antibodies that selectively recognize protein aggregates are leading therapeutic agents for neutralizing toxic aggregates, diagnostic imaging detecting disease, biomedical reagents elucidating disease mechanisms. Despite their importance, it challenging generate high-quality conformational in a systematic site-specific manner...
The increasing prevalence of food allergies has been linked to reduced commensal microbial diversity. In this article, we describe two features allergy-protective Clostridia that contribute their beneficial effects. Some Clostridial taxa bear flagella (a ligand for TLR5) and produce indole the aryl hydrocarbon receptor [AhR]). Lysates from a consortium induced interleukin-22 (IL-22) secretion ileal explants. IL-22 production is abrogated in explants mice which TLR5 or MyD88 signaling...
Abstract Lifestyle-induced changes to the diversity of commensal microbiota have been causally linked increasing prevalence food allergies and other non-communicable chronic diseases. We shown that bacteria from Clostridia class prevent an allergic response by eliciting IL-22 dependent barrier protective limits allergen access systemic circulation. now examined mechanisms which induce this allergy-protective effect. identified taxa in a consortium possess flagella produce indole, are ligands...
Abstract Perturbations to the commensal gut microbiota are associated with increasing prevalence of food allergies. Our lab has reported that colonization germ-free mice feces from healthy, but not cow’s milk allergic, infants protects against anaphylaxis a allergen. Protection was higher levels secondary bile acid (SBA) isodeoxycholic (isoDCA) in healthy-colonized mice. IsoDCA been induce regulatory T cells (Tregs) which suppress inflammation. We hypothesize isoDCA-driven induction mucosal...
Abstract It is well known that accumulated changes in microbiota composition over several decades have contributed to an increase non-communicable chronic diseases. While much effort has been devoted toward achieving a consensus on the microbes, and their products, driving this increase, inconsistent results suggest more research required understand disparity observed outcomes. Previous work from our lab identified consortium of commensal Clostridia alone was sufficient preserve intestinal...